Epizootiološka istraživanja paramfistomoze u goveda

Epidemiological studies were undertaken at slaughter houses, live stock farms, veterinary hospitals and on household buffaloes under different management and climatic conditions in four different districts of the Punjab province. Infection rate was 7.83%, 12.33%, 7.17% and 4.25% respectively in the cattle at the slaughter house, live stock farm, veterinary hospital and at household cattle. Overall the highest prevalence in terms of season, 26% and 14.50%, was recorded during autumn at live stock farms and slaughtered cattle followed by 9.75% veterinary hospitals during summer and the lowest (2.5%) in household cattle was recorded during winter. It was observed that a higher infection rate was recorded in younger cattle (below two years of age) than older (above two years of age). Male cattle were more commonly affected than females. Snails belonging to genera Bulinus, Lymnaea and Planorbis were observed which are responsible for the transmission of paramphistomosis.Provedena su epizootiološka istraživanja paramfistomoze u goveda na klaonicama, farmama, veterinarskim klinikama i manjim gospodarstvima pod različitim uvjetima držanja i klime na području Punjaba. Invadiranost je istražena u četiri različite skupine goveda. Na klaonicama je pronađeno 7,83% invadiranih goveda, dok je na farmama taj broj bio nešto veći i iznosio je 12,33%. Među govedima na klinikama svega 7,17% životinja bilo je invadirano. Najmanji broj invadiranih goveda (4,25%) dokazan je u manjim gospodarstvima. U jesenjim mjesecima zabilježena je najveća učestalost u goveda s farmi (26%) i klaonica (14,50%). U goveda s klinika ljeti je dokazana učestalost od 9,75%. Najmanji broj invadiranih goveda dokazan je zimi u malim obiteljskim gospodarstvima (2,5%). Treba naglasiti da je najveća invadiranost zabilježena u goveda mlađih od 2 godine. Mužjaci su bili češće invadirani od ženki. Terenskim istraživanjima na istom području dokazani su posrednici, puževi iz rodova Bulinus, Lymnaea i Planorbis

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Modified “Rockfall Hazard Rating System for Pakistan (RHRSP)”: An Application for Hazard and Risk Assessment along the Karakoram Highway, Northwest Pakistan

Rockfall is a natural mountain hazard posing a severe threat to people, infrastructure, and vehicles along the transportation corridors. In this research, the standard Rockfall Hazard Rating System (RHRS) is slightly modified for the mountainous terrains of Pakistan through the quantification of animal activity along the highways. In the modified Rockfall Hazard and Rating System for Pakistan (RHRSP), animal activity is scored based on permanent and random animal tracks, shallow and higher altitudes, and shoulder width. The model is applied along the Karakoram Highway (KKH), which traverses a suture between Besham and Dasu (≈78 km), for Rockfall hazard and risk assessment mapping. An inventory of rockfalls, topples, and debris slides is compiled at 30 stations. Results show that rockfalls are mostly of the wedge and topple type failures. Fifty-seven percent of the area falls under the very-high to high hazard zone, 18% under moderate hazard, and 25% covers the low to very low hazard zone. Sixty-seven percent of the stretch is at very-high to high risk, distributed from Dubair to Dasu. The main reason for this risk is associated with narrow road width and limited shoulder width for vehicles. The RHRSP model is also applicable for other highways with the same geological and morphological settings

Modified “Rockfall Hazard Rating System for Pakistan (RHRSP)”: An Application for Hazard and Risk Assessment along the Karakoram Highway, Northwest Pakistan

Rockfall is a natural mountain hazard posing a severe threat to people, infrastructure, and vehicles along the transportation corridors. In this research, the standard Rockfall Hazard Rating System (RHRS) is slightly modified for the mountainous terrains of Pakistan through the quantification of animal activity along the highways. In the modified Rockfall Hazard and Rating System for Pakistan (RHRSP), animal activity is scored based on permanent and random animal tracks, shallow and higher altitudes, and shoulder width. The model is applied along the Karakoram Highway (KKH), which traverses a suture between Besham and Dasu (≈78 km), for Rockfall hazard and risk assessment mapping. An inventory of rockfalls, topples, and debris slides is compiled at 30 stations. Results show that rockfalls are mostly of the wedge and topple type failures. Fifty-seven percent of the area falls under the very-high to high hazard zone, 18% under moderate hazard, and 25% covers the low to very low hazard zone. Sixty-seven percent of the stretch is at very-high to high risk, distributed from Dubair to Dasu. The main reason for this risk is associated with narrow road width and limited shoulder width for vehicles. The RHRSP model is also applicable for other highways with the same geological and morphological settings