7 research outputs found
âAs there are hyena-men and panther-men âŠâ: Chris Abani, Pieter Hugo, and the shocking life of images
Testing organic and organicâinorganic fluorinated hybrid coatings as protective materials for clay bricks
Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease
Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60Â days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of CD2