Serološki odgovor goveda na cijepljenje polivalentnim cjepivom protiv slinavke i šapa, bjesnoće, hemoragijske septikemije i šuštavca.

Five groups of ten animals were vaccinated with a combined vaccine containing foot and mouth disease (FMD), rabies, Pasteurella multocida and Clostridium chauvoei antigens and individual component vaccines containing FMD, rabies, Pasteurella multocida and Clostridium chauvoei antigens, respectively. Serological response of the calves was assayed on days 21 and 90 post vaccination. There was no significant variation in the serological response elicited by individual component vaccines and combined vaccine containing all four antigens.Pet skupina po deset životinja cijepljeno je različitim kombinacijama vakcina. Prva je skupina cijepljena polivalentnim cjepivom koje je sadržavalo antigene virusa slinavke i šapa, virusa bjesnoće te bakterija Pasteurella multocida i Clostridium chauvoei. Ostale su skupine cijepljene pojedinačnim antigenima, pa je tako druga skupina cijepljena antigenima virusa slinavke i šapa, treća antigenima virusa bjesnoće, četvrta antigenima bakterije Pasteurella multocida, a peta antigenima bakterije Clostridium chauvoei. Serološki odgovor svih životinja provjeren je 21. i 90. dana nakon cijepljenja. Na osnovi serološkoga odgovora nisu utvrđene značajne razlike među različitim načinima cijepljenja

Evaluation des BSE-Checks bei weiteren 53 Kühen mit BSE

Gegenstand und Ziel: Beschreibung der klinischen Befunde bei 53 Kühen mit BSE. Material und Methoden: Untersuchung der Kühe mithilfe des BSE-Checks. Ergebnisse: Eine Kuh, die über ein halbes Jahr Verhaltens- und Bewegungsstörungen gezeigt hatte, befand sich im Endstadium der Erkrankung und lag fest. Sie war stuporös und reagierte nicht auf äußere Einflüsse wie Berührung, Lärm und Licht. Die übrigen 52 Kühe zeigten Verhaltensstörungen im Sinne übermäßiger Erregung wie Ängstlichkeit, Schreckhaftigkeit, Nervosität/ Unruhe, Zähneknirschen, Tremor, Speicheln, vermehrtes Belecken des Flotzmauls, vermehrte Abwehrbereitschaft, Flehmen, Glotzaugen und Brüllen. Die Sensibilitätsstörungen äußerten sich in abnehmender Reihenfolge auf Berührung am Kopf mit dem Kugelschreiber (50 Kühe), Lärm (47), Fotoblitz (46), Licht (44) und Berührung der Hinterbeine mit einem Besen (15). Zweiundfünfzig Kühe reagierten auf mindestens eine der Proben überempfindlich. Eine Kuh zeigte bei allen Proben eine hochgradige Überreaktion. Die Bewegung konnte nur bei 43 von 53 Kühen beurteilt werden, da 10 Tiere bereits festlagen. Drei Kühe zeigten beim Vorführen einen normalen Gang, 17 Kühe eine Nachhandataxie und 23 Kühe eine generalisierte Ataxie. Beim anschließenden Freilaufenlassen war auch bei den vorher nicht ataktischen drei Kühen eine leichte Ataxie zu erkennen. Als Besonderheiten wiesen fünf Kühe eine Hypermetrie der Nachhand, neun Tiere ein hahnentrittartiges Zucken einer Hintergliedmaße und 10 Kühe Passgang auf. Weitere abnorme Befunde konnten beim Führen über den Kotgraben des Lagers oder den Spalt der Brückenwaage, beim Durchqueren einer Türöffnung und beim Überschreiten einer am Boden liegenden Stange beobachtet werden. Schlussfolgerung: Durch die gezielte klinische Untersuchung auf BSE zeigen sich viele Facetten des Krankheitsbildes, die bei alleiniger Beobachtung nicht zu erkennen sind. Klinische Relevanz: Die klinische Untersuchung stellt immer noch die beste Methode dar, um Kühe mit BSE zu identifizieren

Klinischer Untersuchungsgang bei Verdacht auf bovine spongiforme Enzephalopathie (BSE)

The most important clinical signs of BSE are hypersensitivity to manipulations of the head and neck and disturbances in behaviour and locomotion. Diagnostic procedures include thorough clinical and neurological examination with emphasis on the assessment of behaviour, locomotion and sensitivity. The findings have to be interpreted carefully and depending on the diagnosis, national animal health regulations must be followed

Serološki odgovor goveda na cijepljenje polivalentnim cjepivom protiv slinavke i šapa, bjesnoće, hemoragijske septikemije i šuštavca.

Five groups of ten animals were vaccinated with a combined vaccine containing foot and mouth disease (FMD), rabies, Pasteurella multocida and Clostridium chauvoei antigens and individual component vaccines containing FMD, rabies, Pasteurella multocida and Clostridium chauvoei antigens, respectively. Serological response of the calves was assayed on days 21 and 90 post vaccination. There was no significant variation in the serological response elicited by individual component vaccines and combined vaccine containing all four antigens.Pet skupina po deset životinja cijepljeno je različitim kombinacijama vakcina. Prva je skupina cijepljena polivalentnim cjepivom koje je sadržavalo antigene virusa slinavke i šapa, virusa bjesnoće te bakterija Pasteurella multocida i Clostridium chauvoei. Ostale su skupine cijepljene pojedinačnim antigenima, pa je tako druga skupina cijepljena antigenima virusa slinavke i šapa, treća antigenima virusa bjesnoće, četvrta antigenima bakterije Pasteurella multocida, a peta antigenima bakterije Clostridium chauvoei. Serološki odgovor svih životinja provjeren je 21. i 90. dana nakon cijepljenja. Na osnovi serološkoga odgovora nisu utvrđene značajne razlike među različitim načinima cijepljenja

Untersuchungen an 182 Nachkommen von an boviner spongiformer Enzephalopathie (BSE) erkrankten Kühen in der Schweiz, Teil 1. Klinische Befunde

This study involved 182 calves, heifers and cows that were the first generation progeny of cows with bovine spongiform encephalopathy (BSE). All animals underwent clinical and neurological examinations. Blood, milk, urine, ruminal fluid and cerebrospinal fluid samples were examined. Each cow underwent a specific examination for BSE which included assessment of behaviour, sensitivity and locomotion. This examination was performed twice, and there was very good agreement between the results. The most common symptom was nervousness (14 animals). In the first examination, 68 animals were mildly to moderately sensitive to touching of the head, 44 animals were hypersensitive to a halogen light and 35 animals were hypersensitive to a camera flash. Twenty-four animals reacted by kicking when the hindlimbs were touched with a broom. None of the animals had disturbances in locomotion. Based on the interpretation of all findings and the comparison of the results of the first and second examinations, 173 animals were diagnosed as free of BSE. In 9 animals, the disease could not be ruled out; however, it could not be confirmed in any of them. Histological and immunohistochemical examinations of the brain of all animals were negative for BSE (see Part 2 of the study for details). The results of this study indicate that abnormal clinical findings may occur in clinically healthy cattle. However, none of the progeny of cows with BSE exhibited clinical signs typical of BSE, such as disturbances in behaviour, sensitivity and locomotion