Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant

The potential of tumor cells (J558L) engineered to produce one of 5 different cytokines (interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or gamma-interferon) to give rise to systemic immunity protective against a contralateral challenge with the parental cells was analyzed. The rejection of all cytokine-producing cells appeared to induce some systemic response capable of mediating the rejection of low numbers of subsequently contralaterally injected cells, but the effect was much less obvious with higher cell numbers. The injection of any possible combination of two of the cytokine producers did not reveal any synergistic effects. The cytokine gene-transfected tumor cells were not superior to the parental cells admixed with the adjuvant Corynebacterium parvum with respect to their potential as immunogens to induce immunity

Forschungs- und Koordinierungsstelle des Bayerischen Forschungsverbundes Public Health - Oeffentliche Gesundheit 1997-2001

SIGLEAvailable from TIB Hannover: RR 9321(2002,12)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman

AIDS-Verbund Wuerzburg. Die Funktion und pathogenetische Bedeutung der Proteine Vpr, Vpx und Nef im SIV-Makaken-Modell. Teilprojekt 1: Die Bedeutung der Proteine Vpr und Vpx fuer Virusreplikation und Pathogenese Schlussbericht

Summaries in EnglishAvailable from TIB Hannover: DtF QN1(70,56) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman