Hubungan Antara Intensitas Aktivitas Fisik Dan Kadar Asam Urat Serum Pada Populasi Sindrom Metabolik

Background: WHO estimated that the prevalence of metabolic syndrome was occured in 23% of male population and 12% of female population in the world. Hyperuricemia had a strong relationship with each component of metabolic syndrome. Earlier studies reported that physical activity played an important role to prevent hyperuricemia.Aim: To find out the assosiation between intensity of physical activity and serum uric acid levels in metabolic syndrome population.Methods: This study was an observational analytic study with cross-sectional design. This study was conducted in RW X, Padangsari, Banyumanik, Semarang in a population based sample aged over 40. The collected data are subject characteristics, serum uric acid levels, andintensity of physical activity. Global physical activity questionnaire (GPAQ), developed by WHO, was used to determine the intensity of physical activity. The Spearman test and chi- square test were used for the statistical analyses.Results: The data showed that 40,6% of 32 subjects with metabolic syndrome had light physical activity, 25% had moderate physical activity and 34,4% had vigorous physical activity. The examination of serum uric acid levels showed that 40,6 % of them had high serum uric acid levels. The Spearman test showed a moderate degree positive correlation between intensity of physical activity and serum uric acid levels (r=0,491; p=0,004). The chi-square test showed a significant relationship between intensity of physical activity categories and serum uric acid levels categories (p=0,023; prevalence ratio 4,17).Conclusions: There was a positive correlation with a moderate degree between intensity of physical activity and serum uric acid levels in metabolic syndrome population

A Multisectoral Approach in Dengue Management in Seremban Malaysia: an Ecobiosocial Perspective

Background: Dengue has been established as a major public health issue in many parts of the world particularly those in the tropical regions. In Malaysia, the rising rate of dengue cases had remained uncurbed, alarming to both the public and the local authorities. Despite the existence of legislations and control activities, why does the number of dengue cases keep on increasing every year? The objective of this study was to assess the existing environmental and health policies/strategies towards sustainable prevention and control of dengue/DHF in Malaysia. In addition, it also aimed to review the eco-bio-social approach and its advantages in prevention and control of dengue. Subjects and Method: Series of in-depth interviews were conducted on 12 key- informants aged between 36-58 years old. They were selected based on their roles that were divided into three categories, i.e. (1) policy makers, (2) middle managers, and (3) implementers at the ground level. Each interview explored in detail, on the important domains which were the ecology, biology, and social factors. Each session took an average of 45 minutes to 1 hour. There were a total of 10 males and 2 females selected for the in-depth interview. Open-ended questions were asked and the interviews were voice recorded, after obtaining consent from the respondents. The interviews were terminated once data saturation was achieved. The qualitative data was analyzed using Atlas.ti software. Results: The three main themes that emerged and were identified to contribute to sustainable dengue control and prevention were (1) adequate implementation of existing health policy, (2) good integration and coordination between agencies, (3) commitment from political and community leaders. Local data showed that areas which did not have these important components became hot spots for dengue with high number of dengue cases. Conclusion: It is vital that the community and relevant authorities focus on these themes/domains that will significantly improve the chances of having sustainable denguecontrol and management program in their localities. Keywords: multisectoral approach, ecobiosocial, engue control, sustainable managemen

Knowledge-Based Collaborative Lean Manufacturing Management (KBCLMM) system

The objective of this research paper is to demonstrate the application of hybrid Knowledge-Based System, Gauging Absences of Pre-Requisites (GAP), and Analytic Hierarchy Process (AHP) approaches for selecting the improvement programs for Collaborative Lean Manufacturing Management (CLMM) System.In this research, a generic Knowledge-Based System is developed to measure the level of CLMM adoption in automotive manufacturers compared to the ideal system. Using the embedded GAP and AHP technique, the key lean manufacturing improvement programs can be prioritised by using both qualitative and quantitative criteria.The analysis covers the planning stage of the KBCLMM. The utilisation of the approach is demonstrated with an illustrative example

Neurophysiology

Contains research objectives and summary of research.National Institutes of Health (Grant 1 RO1 EY01149-01)National Institutes of Health (Grant 5 P01 GM14940-07)Bell Telephone Laboratories, Inc. (Grant)National Institutes of Health (Grant 5 TO1 GM01555-07)M. I. T. Sloan Fund for Basic Researc

Neurophysiology

Contains reports on twenty research projects.Bell Laboratories (Grant)National Institutes of Health (Grant 5 R01 EY01149-03S2)National Institutes of Health (Grant 5 TO1 EY00090-04)National Institutes of Health (Grant 5 RO1 NS12307-03)National Institutes of Health (Grant K04 NS00010)National Multiple Sclerosis Society (Grant RG-1133-A-1)Health Sciences Fund (Grant 78-10

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event

Treatment of hallux valgus by modified McBride procedure: a 6-year follow-up

PubMed ID: 20505975Background Surgical decision-making was reevaluated by comparison with an algorithm designed to analyze treatment of hallux valgus deformities. Materials and methods A modified McBride procedure was performed on 52 feet of 35 patients with hallux valgusdeformity. From this series, 36 feet of 21 patients were evaluated preoperatively, early postoperatively, and late postoperatively by means of subjective evaluation and clinical and radiological findings. Results The hallux valgus angle preoperatively, early postoperatively, and late postoperatively was 32.7 ± 8.5°, 10.1 ± 6.9°, and 20.6 ± 9.5°, respectively. Hallux valgus recurrence of 72.2% was observed. Subjective results were better and the patients rated their satisfaction with the procedure as excellent or high in 23 cases (63.9%) and moderate, low, or unsatisfactory in 13 cases (36.1%). Conclusions This level of patient satisfaction demonstrates that the McBride procedure is an efficient approach for eliminating pain due to hallux valgus deformity. © The Author(s) 2010

Treatment of hallux valgus by modified McBride procedure: a 6-year follow-up

PubMed ID: 20505975Background Surgical decision-making was reevaluated by comparison with an algorithm designed to analyze treatment of hallux valgus deformities. Materials and methods A modified McBride procedure was performed on 52 feet of 35 patients with hallux valgusdeformity. From this series, 36 feet of 21 patients were evaluated preoperatively, early postoperatively, and late postoperatively by means of subjective evaluation and clinical and radiological findings. Results The hallux valgus angle preoperatively, early postoperatively, and late postoperatively was 32.7 ± 8.5°, 10.1 ± 6.9°, and 20.6 ± 9.5°, respectively. Hallux valgus recurrence of 72.2% was observed. Subjective results were better and the patients rated their satisfaction with the procedure as excellent or high in 23 cases (63.9%) and moderate, low, or unsatisfactory in 13 cases (36.1%). Conclusions This level of patient satisfaction demonstrates that the McBride procedure is an efficient approach for eliminating pain due to hallux valgus deformity. © The Author(s) 2010