A hantavirus infection case report from rural area of kazan district, ankara Ankara Ili Kazan Ilçesi kirsal bölgesinden bir hantavirüs enfeksiyonu olgusu

Hantaviruses as a member of the family Bunyaviridae are RNA viruses with enveloped, negative-sense, single-stranded segmental genome. Today, more than 20 different Hantavirus species are recognized. Eleven of them cause clinical symptoms in humans. Hantaan (HTNV), Puumala (PUUV), Dobrava (DOBV), Seoul viruses causes different forms of hemorrhagic fever with renal syndrome (HFRS), since Sin Nombre virus and Sin Nombre-like viruses found especially in the United States causes hantaviruses pulmonary syndrome (HPS) with high mortality. In our country, infections have been reported with subtypes of the Hantaviruses firstly PUUV in the Western Black Sea region, then DOBV from Giresun and Kastamonu. A case of Hantavirus infection similarly in the form of RSHF from the rural area of Kazan district in Ankara has been reported in this article. Sixty-seven-year-old male patient was admitted to the emergency room with complaints of dizziness, fever and fatigue in June of 2011. Leukopenia, thrombocytopenia elevated liver enzymes and creatinine was detected in laboratory investigations at emergency room. The patient hospitalized and followed with initial diagnosis of Crimean-Congo Hemorrhagic Fever (CCHF). Further investigation of the serum samples at the Refik Saydam Hygiene Center and Research Laboratory of Virology with indirect immunofluorescent antibody (IFA) ((Hantaviruses Mosaic-1, Euroimmun, Germany) resulted in weakly positivity of anti-hantavirus IgM and IgG. The first serum samples revealed negative by immunoblot test (Euroimmun, Germany). After 11 days second sample of patient revealed DOBV positivite with both IFA and immunoblot serologically. In-house RT - Polimerase Chain Reaction (PCR) test was found to be negative in the first serum sample of the patient. This case is important of being the first HFRS infection reported from Ankara