Shoulder Injury in a Female Soccer Goalie

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Triggered Star Formation and Dust around Mid-Infrared-Identified Bubbles

We use Two Micron All Sky Survey, GLIMPSE, and MIPSGAL survey data to analyze the young stellar object (YSO) and warm dust distribution around several mid-infrared-identified bubbles. We identify YSOs using J-band to 8 um photometry and correlate their distribution relative to the PDR (as traced by diffuse 8 um emission) which we assume to be associated with and surround a HII region. We find that only 20% of the sample HII regions appear to have a significant number of YSOs associated with their PDRs, implying that triggered star formation mechanisms acting on the boundary of the expanding HII region do not dominate in this sample. We also measure the temperature of dust inside 20 HII regions using 24 um and 70 um MIPSGAL images. In eight circularly symmetric sources we analyze the temperature distribution and find shallower temperature gradients than is predicted by an analytic model. Possible explanations of this shallow temperature gradient are a radially dependent grain-size distribution and/or non-equilibrium radiative processes.Comment: 35 pages, 17 figures, accepted for publication in Ap

Shoulder Injury in a Female Soccer Goalie

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Identification of a novel agrin-dependent pathway in cell signaling and adhesion within the erythroid niche

Establishment of cell–cell adhesion is crucial in embryonic development as well as within the stem cell niches of an adult. Adhesion between macrophages and erythroblasts is required for the formation of erythroblastic islands, specialized niches where erythroblasts proliferate and differentiate to produce red blood cells throughout life. The Eph family is the largest known family of receptor tyrosine kinases (RTKs) and controls cell adhesion, migration, invasion and morphology by modulating integrin and adhesion molecule activity and by modifying the actin cytoskeleton. Here, we identify the proteoglycan agrin as a novel regulator of Eph receptor signaling and characterize a novel mechanism controlling cell–cell adhesion and red cell development within the erythroid niche. We demonstrate that agrin induces clustering and activation of EphB1 receptors on developing erythroblasts, leading to the activation of α5β1 integrins. In agreement, agrin knockout mice display severe anemia owing to defective adhesion to macrophages and impaired maturation of erythroid cells. These results position agrin-EphB1 as a novel key signaling couple regulating cell adhesion and erythropoiesis