Facilitating wound bed preparation: properties and clinical efficacy of octenidine and octenidine-based products in modern wound management

In times when the empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance, the following supplement addresses how topical antiseptics, such as octenidine dihydrochloride (OCT), are less likely to induce resistance. An analysis on how wound cleansers can be used to debride the wound surface without damaging healthy cells is also detailed. This is followed by a series of 18 case studies showing the use of Octenilin Wound Gel and Octenilin Wound Irrigation Solution on non-healing and/or infected or critically colonised non-healing wounds of different wound types including: diabetic foot ulcers, venous leg ulcers and pressure ulcers, among others.Accepted manuscrip

Activity of chemolithotrophic nitrifying bacteria under stress in natural soils

Nitrification is an important process in the biogeochemical cycle of nitrogen, linking its reduced and oxidized parts. Since the conversion of ammonium to nitrate has a great impact on the environment, such as weathering of soils, production of greenhouse gases, and eutrophication of surface and ground waters, it is important to know the characteristics of the responsible organisms. Although many organotrophic microorganisms are able to produce oxidized nitrogenous compounds such as nitrite and nitrate, chemolithotrophic nitrifying bacteria are considered to be the most important group producing these compounds from ammonia. A contribution to nitrate production by organotrophic microorganisms has only been observed in some acid coniferous forest soils