10 research outputs found
Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 01/01/2018
- Field of study
Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for assessing the effects of pharmacological inhibition of MTH1 on tumor cell survival, both in vitro and in vivo. (1) In this report, we describe the medicinal chemistry program creating BAY-707, where fragment-based methods were used to develop a series of highly potent and selective MTH1 inhibitors. Using structure-based drug design and rational medicinal chemistry approaches, the potency was increased over 10,000 times from the fragment starting point while maintaining high ligand efficiency and drug-like properties
Interaction and complexation of phospholipid vesicles and triblock copolymers
- Author
- Agrawal S. K.
- Akutsu H.
- Alakhov V.
- Alakhov V.
- Alexandridis P.
- Almgren M.
- Batrakova E. V.
- Batrakova E. V.
- Bentley M. V. L. B.
- Bergstrand N.
- Bochot A.
- Chaibundit C.
- Chandaroy P.
- Chang L. C.
- Chang L. C.
- Chern C. S.
- Demina T.
- Du H.
- Erukova V. Yu.
- Exner A. A.
- Fukuda K.
- Gaucher G.
- Gilbert J. C.
- Grassi G.
- Hrubý M.
- Huang C.
- Huh K. M.
- Hui S. W.
- Inoue T.
- Jamshaid M.
- Johnsson M.
- Kabanov A. V.
- Kabanov A. V.
- Kostarelos K.
- Kragh-Hansen U.
- Kresheck G. C.
- Krylova O. O.
- Kuhl T.
- Könczöl F.
- Lasonder E.
- Liang X. M.
- Lichtenberg D.
- Lichtenberg D.
- Litzinger D. C.
- Liu J.
- Meulenaer B. D.
- Minko T.
- Mishima K.
- Oh K. T.
- Pantusa M.
- Pappalardo M.
- Ruysschaert T.
- Sabín J.
- Schmolka I. R.
- Silvander M.
- Silvander M.
- Simard P.
- Soga O.
- Tan A.
- Taylor K. M. G.
- Venema F. R.
- Wang G. Q.
- Woodle M. C.
- Woodle M. C.
- Zhirnov A. E.
- Šegota S.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 11/12/2009
- Field of study
10.1021/jp906929uJournal of Physical Chemistry B1134514934-14942JPCB
Interaction of Cetylpyridinium Chloride with Giant Lipid Vesicles
- Author
- Akashi K.
- Almgren M.
- Angelova M. I.
- Cevc G.
- Cocera M.
- Goddard E. D.
- Gomišček G.
- Hayakawa K.
- Heerklotz H.
- Heerklotz H.
- Helenius A.
- Hiemenz P. C.
- Jurman-Gros T.
- Jönsson B.
- Kadi M.
- Karpovich S. D.
- Keller A.
- Kragh-Hansen U.
- Kwak J. C. T.
- Lantzsch G.
- Lasch J.
- Lasch J.
- Lasch J.
- Lasič D. D.
- Levy D.
- Lichtenberg D.
- Lichtenberg D.
- Lopez O.
- Mally M.
- Paternostre M.
- Reeves J. P.
- Satake I.
- Schubert R.
- Silvander M.
- Tan A.
- Tanaka T.
- Wenk M. R.
- Škerjanc J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Aggregate Structures in a Dilute Aqueous Dispersion of a Fluorinated/Hydrogenated Surfactant System. A Cryo-Transmission Electron Microscopy Study
- Author
- Akune T.
- Almgren M.
- Almgren M.
- Almgren M.
- Asakawa T.
- Asakawa T.
- Asakawa T.
- Beguin S.
- Bellare J. R.
- Burkitt S. J.
- Caporiccio G.
- Chevalier Y.
- De Lisi R.
- Dubochet J.
- Edwards K.
- Edwards K.
- Edwards K.
- Fletcher P. D.
- Fromherz P.
- Funasaki N.
- Gauthier-Fournier F. Ph.D.
- Gross U.
- Gross U.
- Hoffmann H.
- Knoblich A.
- Kunitake T.
- Lasic D. D.
- Lasic D. D.
- Marignan J.
- Marques E. F.
- Monduzzi M.
- Mukerjee P.
- Oberdisse J.
- Ravey J. C.
- Riess J. G.
- Riess J. G.
- Riess J. G.
- Ristori S.
- Ristori S.
- Ristori S.
- Ristori S.
- Rossi S.
- Shinoda K.
- Silvander M.
- Talmon Y.
- Trabelsi H.
- Vinson P. K.
- Walter A.
- Wang K.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Octyl Glucoside-Mediated Solubilization and Reconstitution of Liposomes: Structural and Kinetic Aspects
- Author
- Allen T. M.
- Almog S.
- Angelov B.
- Bogusz S.
- Cladera J.
- Das T. K.
- Das T. K.
- De la Maza A.
- De la Maza A.
- De la Maza A.
- Edwards K.
- Edwards K.
- Egelhaaf S. U.
- Entenmann A.
- Goñi F. M.
- Heerklotz H.
- Israelachvilli J.
- Jackson M. L.
- Keller M.
- Knol J.
- Koppel D. E.
- Kragh-Hansen U.
- Lacapere J. J.
- Lambert O.
- Lasch J.
- Le Marie M.
- Levy D.
- Lichtenberg D.
- Lorber B.
- López O.
- López O.
- López O.
- López O.
- Oberdisse J.
- Ollivon M.
- Ollivon M.
- Parmar M. M.
- Partearroyo A.
- Paternostre M.
- Patist A.
- Polozova A. I.
- Rigaud J. L.
- Schurtenberger P.
- Shinoda K.
- Silvander M.
- Singleton W. S.
- Southan G.
- Van Ede J.
- Vinson P. K.
- Wenk M. R.
- Zheng Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Optical Properties of ZnO Quantum Dots in Epoxy with Controlled Dispersion
- Author
- Abdullah M.
- Abdullah M.
- Alivisatos A. P.
- Alivisatos A. P.
- Althues H.
- Artemyev M. V.
- Beek W. J. E.
- Beek W. J. E.
- Brus L.
- Brus L.
- Brus L. E.
- Demchenko D. O.
- Demir M. M.
- Demir M. M.
- Demir M. M.
- Du X. W.
- Efros A. L.
- Fonoberov V. A.
- Guo L.
- Hooper J. B.
- Huynh W. U.
- Huynh W. U.
- Kagan C. R.
- Kagan C. R.
- Khrenov V.
- Kickelbick G.
- Kim B. S.
- Lee J.
- Li Y. Q.
- Michalet X.
- Monticone S.
- Murray C. B.
- Murray C. B.
- Norris D. J.
- Norris D. J.
- Peng X. G.
- Sheng W. C.
- Silvander M.
- Spanhel L.
- Sun D.
- Sun D. Z.
- Sun L. Y.
- Sun L. Y.
- van Dijken A.
- Xia J. B.
- Xiong H. M.
- Yang R. D.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Micellization of Dissymmetric Cationic Gemini Surfactants and Their Interaction with Dimyristoylphosphatidylcholine Vesicles
- Author
- Almgren M.
- Bai G. Y.
- Bai G. Y.
- Bai G. Y.
- Bakshi M. S.
- Bakshi M. S.
- Diamant H.
- Dubničková M.
- Edwards K.
- Edwards K.
- Fattal D. R.
- Heerklotz H.
- Heerklotz H.
- Heerklotz H.
- Heerklotz H.
- Heerklotz H.
- Hildebrand A.
- Hildebrand A.
- Huc I.
- Johnsson M.
- Keller M.
- Kragh-Hansen U.
- Levy D.
- Li Y. J.
- Lichtenberg D.
- Lichtenberg D.
- Lichtenberg D.
- López O.
- Majhi P. R.
- Mazer N. A.
- Menger F. M.
- Menger F. M.
- Mosquera V.
- Oda R.
- Oda R.
- Pata V.
- Roth Y.
- Schnitzer E.
- Sikirić M.
- Sikirić M.
- Silvander M.
- Song Li. D.
- Tan A.
- Wang X. Y.
- Zana R.
- Zana R.
- Zana R.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Socio-economic consequences of aquatic liming
- Author
- A Karlén
- AF Radford
- ALW Toumi
- Anonymous
- Anonymous
- B Bengtsson
- B Bergquist
- B Lagerman
- B Lindgren
- B Wallenberg
- Blekinge County Council
- Blekinge County Council
- BO Andersson
- Butlin
- C Bernes
- D Talhelm
- Dalarna County Council
- E Degerman
- E Erlandsson-Hammargren
- E Thörnelöf
- G Andersson
- I Ahlén
- I Norling
- J Rolfsen
- K Hjalte
- Kronoberg County Council
- Kronoberg County Council
- Kronoberg County Fishing Board
- Kronoberg County Fishing Board
- Kronoberg County Fishing Board
- Kronoberg County Fishing Board 1991. Fångsstatistik insjöfisket
- L Håkanson
- L Nyman
- M Appelberg
- MOG Eriksson
- MOG Eriksson
- National Board of Fisheries
- National Board of Fisheries
- National Board of Fisheries
- National Food Administation
- North Atlantic Salmon Conservation Organization (NASCO)
- O Lessmark
- OECD
- P Nyberg
- R Lundström
- S Agency
- S Andreasson
- S Navrud
- S Navrud
- S Navrud
- S Navrud
- S Sweden
- S Sweden
- Skaraborg County Council
- Skaraborg County Council
- Skaraborg County Fishing Board
- Swedish Anglers Association
- SwedishEnvironmentalProtection
- T Andersson
- U Silvander
- Uppsala County Council
- W Dickson
- Å Häggström
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Permeability Enhancement of Lipid Vesicles to Nucleotides by Use of Sodium Cholate: Basic Studies and Application to an Enzyme-Catalyzed Reaction Occurring inside the Vesicles
- Author
- Albalak A.
- Almog S.
- Almog S.
- Annesini M. C.
- Annesini M. C.
- Bangham J. A.
- Blocher M.
- Blöchliger E.
- Cabral D. J.
- Chakrabarti A. C.
- Chonn A.
- Cohen D. E.
- Cornell B. A.
- de La Maza A.
- de la Maza A.
- Donovan J. M.
- Donovan J. M.
- Dorovska-Taran V.
- Edwards K.
- Heywood B. R.
- Hope M. J.
- Huang C.
- Hunt G. R. A.
- Hunter D. G.
- If
- Inoue T.
- Kamp F.
- Kaszuba M.
- Kennedy M. T.
- Kragh-Hansen U.
- Lasch J.
- Levy D.
- Lichtenberg D.
- Lichtenberg D.
- Lichtenberg D.
- Lonchin S.
- López O.
- MacDonald R. C.
- Malloy R. C.
- Mayer L. D.
- Meyuhas D.
- Monnard P.-A.
- Nagawa Y.
- Nomura F.
- O'Connor C. J.
- Oberholzer T.
- Ollila F.
- Paternostre M.
- Paternostre M.-T.
- Petkau A.
- Rigaud J.-L.
- Roth Y.
- Ruiz J.
- Schubert R.
- Schubert R.
- Schurtenberger P.
- Silvander M.
- Stewart J. C. M.
- Stillwell W.
- Sun C.
- Tahara Y.
- Ueno M.
- Ueno M.
- Walde P.
- Walde P.
- Walde P.
- Walde P.
- Wenk M. R.
- Young M.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
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- L Björkman
- L Björkman
- L Björkman
- L Chou
- L Christersson
- L Edenius
- L Edenius
- L Edenius
- L Hallbäcken
- L Hallbäcken
- L Hannah
- L Hansson
- L Hultkrantz
- L Kaila
- L Kardell
- L Kärenlampi
- L Lindgren
- L Lodin
- L Mattsson
- L Skärby
- L Skärby
- L Skärby
- L Skärby
- L Östlund
- L-A Shipley
- L-A Shipley
- L-A Shipley
- L-E Liljelund
- L-E Liljelund
- L-L Hung
- L-O Nilsson
- L-O Wikars
- L-O Wikars
- L-O Wikars
- L-O. Nilsson
- LA Renecker
- LD Emberson
- LE Allison
- LE Band
- LE Frelich
- LE Sommers
- LG Marklund
- LH McCormick
- LH McCormick
- LJ Larsson
- LJ Larsson
- LJ Lundgren
- LJ Samuelson
- LM Mortensen
- LM Mortensen
- LM Mortensen
- M Alveteg
- M Amcoff
- M Appelberg
- M Becker
- M Bonneau
- M Bredemeier
- M Dinnin
- M Elzen den
- M Ferretti
- M Genuchten van
- M Guorley
- M Hannerz
- M Hovmand
- M Ingerslev
- M Jonsell
- M Jonsell
- M Jonsell
- M Kam de
- M Karlsson
- M Karlsson
- M Lindbladh
- M Lindbladh
- M Lindbladh
- M Lindén
- M Lippert
- M Ljungström
- M Ljungström
- M Ljungström
- M Löf
- M Meyberg
- M Monsi
- M M’Gonigle
- M M’Gonigle
- M Neitzke
- M Niklasson
- M Niklasson
- M Niklasson
- M Oliver
- M Olsson
- M Olsson
- M Pietilä
- M Quemada
- M Runkel
- M Salemaa
- M Scheffer
- M Schnitzer
- M Schöttelndreier
- M Sjöstrand
- M Soedarjo
- M Stanford
- M Sudhaus
- M Sykes
- M Tesche
- M Velbel
- M Velbel
- M Vuorinen
- M Warren
- M Wood
- M-B Johansson
- M-J Gaillard
- M.A. McCarthy
- MA Oliver
- MA Oliver
- MA Sindhu
- MA Spetich
- MC Speight
- MD Abrams
- MD Korzukhin
- ME Anderson
- ME Harmon
- ME Soulé
- ME Soulé
- MG Raphael
- MG Reed
- MGM Bruggenwert
- MGR Cannell
- MH Zimmermann
- MHR Browning
- MJ Kelty
- MJ Swift
- MJ Wilson
- MJF Pelt van
- MJI Briones
- MK Burke
- ML Jackson
- MM Larson
- MM Müller
- MP Berg
- MP Marchak
- MR Raupach
- MR Raupach
- MS Günthardt-Goerg
- MT Sykes
- MT Tyree
- MT Tyree
- N Christophersen
- N Cressie
- N Fahlvik
- N Owen-Smith
- N Whitehouse
- National Board of Forestry
- National Board of Forestry
- NC Brady
- NE Grulke
- NG Mortensen
- NG Tilghman
- NJ Rosenberg
- NM Darrall
- NM Rose
- NT Edwards
- NT Welander
- O Andrén
- O Clarke
- O Kårén
- O Langvall
- O Langwall
- O Levenspiel
- O Liberg
- O Osonubi
- O Westling
- O Zackrisson
- OA Hougen
- ON Krankina
- P Aagaard
- P Angelstam
- P Atkins
- P Bader
- P Bahn
- P Barklund
- P Barklund
- P Barklund
- P Ehrlich
- P Eliasson
- P Eliasson
- P Fredman
- P Gemmel
- P Green
- P Gundersen
- P Gundersen
- P Gundersen
- P Hazell
- P Ineson
- P Kram
- P Lagerås
- P Lagerås
- P Lohmander
- P Lucas
- P Lundberg
- P Lundberg
- P Lundberg
- P Mikkola
- P Niemela
- P Nowicki
- P Oker-Blom
- P Persson
- P Saetre
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Schlyter
- P Stjernquist
- P Stjernquist
- P Thorén
- P Uomala
- P Wagner
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P Warfvinge
- P-E Jansson
- P-E Lingdell
- P-O Johansson
- PA Melkerud
- PB Reich
- PB Reich
- PC Buckland
- PC Buckland
- PD Manion
- PG Jarvis
- PG Waterman
- PG Whitehead
- PH Freer-Smith
- PJ Ball
- PJ Kramer
- PJ Osborne
- PJ Osborne
- PJ Ryan
- PK Donelly
- PK McConnaughey
- PK McConnaughey
- PK McConnaughey
- PM Ekö
- PM Groffman
- PM Niemela
- Praktisk Skogshandbok
- PT Harding
- PW Flanagan
- R Andersen
- R Andersson
- R Bergström
- R Costanza
- R Daubenmire
- R Eckersley
- R Geiger
- R Gilman
- R Grote
- R Grote
- R Grote
- R Grote
- R Heikkilä
- R Koitzsch
- R Lensi
- R Man
- R Matyssek
- R Matyssek
- R Moen
- R Morris
- R Perman
- R Pott
- R Siwecki
- R Tischner
- R Webster
- R Worrel
- R Wright
- R-L Petäistö
- R-R Sokal
- R. Perrin
- RA Fisher
- RA Skeffington
- RB Norgaard
- RB Norgaard
- RB Walker
- RC France
- RC Santore
- RD Miller
- RD Wiliams
- RD Wiliams
- RE Dickson
- RE McArdle
- RF Hiittl
- RF Hiittl
- RG Amundson
- RH Brooks
- RH Jongbloed
- RH MacArthur
- RH Peters
- RH Warin
- RH Waring
- RH Waring
- RHW Bradshaw
- RJ Bragg
- RJ Keenan
- RK Dixon
- RK Swihart
- RKJ Myers
- RL Korol
- RM May
- RMA Gill
- RMA Gill
- RO Squire
- RP Leersnijder
- RR Hofmann
- RS Meldahl
- RT Palo
- RTT Forman
- S Anderberg
- S Anderson
- S Braun
- S Gherini
- S Hagner
- S Holm
- S Hultengen
- S Härkönen
- S Härkönen
- S Hågvar
- S Hörnberg
- S Kay
- S Kellomäki
- S Krupa
- S Krupa
- S Larsson
- S Linder
- S Liu
- S Majdi
- S McLaughlin
- S Patrick
- S Rust
- S Soikleli
- S Struwe
- S Struwe
- S Sutinen
- S Sutinen
- S Sutinen
- S Sylvén
- S Welinder
- S Wibe
- S Wijk
- S-E Wieren van
- SA Alexander
- SA Cowling
- SA Levin
- SB McLaughlin
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SG Nilsson
- SJ Hillier
- SJ Thirgood
- SL Gulmon
- SM Smeulders
- SNV
- SNV
- SNV
- SOU
- SOU
- SOU
- Statistical Yearbook of Forestry
- SV Ollinger
- SW Pacala
- SW Running
- SW Running
- SW Running
- Swedish Board of Forestry
- Swedish University of Agricultural science
- Swedish University of Agricultural science
- T Bramryd
- T Bramryd
- T Ericsson
- T Holopainen
- T Ingestad
- T Ingestad
- T Jung
- T Jung
- T Jung
- T Jung
- T Kowalski
- T Kowalski
- T Magura
- T Näsholm
- T Ohno
- T O’Riordan
- T Paces
- T Paces
- T Paces
- T Palm
- T Persson
- T Ranius
- T Ranius
- T Ranius
- T Ranius
- T Ranius
- T Rosswall
- T Rosswall
- T Rosswall
- T Tischner
- TA Brandner
- TC Hsiao
- TC Hutchinson
- TG Wood
- The National Atlas of Sweden The Forest
- TK Kirk
- TK Kozlowski
- TM Hinckley
- TN Sieber
- TR Wildung
- TW Svenson
- TW Willison
- U Arup
- U Bertills
- U Falkengren-Grerup
- U Falkengren-Grerup
- U Falkengren-Grerup
- U Falkengren-Grerup
- U Falkengren-Grerup
- U Falkengren-Grerup
- U Gärdenfors
- U Gärdenfors
- U Jönsson
- U Nilsson
- U Nordén
- U Nordén
- U Nyström
- U Rosengren-Brinck
- U Rosengren-Brinck
- U Rosengren-Brinck
- U Rosengren-Brinck
- U Rundlöf
- U Silvander
- U Söderberg
- U Söderström
- U Wiktander
- UN/ECE and EC 2000. Forest condition in Europe
- V Guthörl
- V Joosten
- V Nicolai
- VA Orchard
- VA Orchard
- VC Farmer
- VD Kucera
- VR Timmer
- W Bergmann
- W Fliickiger
- W Fliickiger
- W Larcher
- W Nast
- W Stumm
- W Vries de
- WA Basset
- WB McGill
- WE Faber
- WE Reifsnyder
- WJ Parton
- WK Jaeger
- WO Binns
- World Commission on Environment and Development
- WR Day
- WS Dancer
- Y Kullberg
- Y Kullberg
- YM Debrinyuk
- Z Lin
- Å Berg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2002
- Field of study