Turkey

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TERMINALIA CHEBULA: AN EPHEMERAL GLANCE

Herbal drugs represent a major allocation of all the recognized systems of health in the world. Also, the medicinal plants have been regarded as valuable and cheap sources of various phytoconstituents which are used extensively in the development of drugs against various diseases. Terminalia chebula, commonly called as black myrobalan, ink tree, or chebulic myrobalan, is a deciduous tree belonging to the family Combretaceae, has been regarded as one of the most important medicinal plants used in medicines of ayurveda, siddha, unani and homeopathy. Numbers of phytochemical constituents have been found to be associated with the drug such as tannins, chebulinic acid, ellagic acid, gallic acid, punicalagin and flavonoids. Moreover, Terminalia chebula has been well reported to possess antioxidant, antidiabetic, antibacterial, antiviral, antifungal, anticancerous, antiulcer, antimutagenic and wound healing activities. In addition, Terminalia chebula has been used extensively in the preparation of many Ayurvedic formulations for infectious diseases like chronic ulcer, leucorrhoea, pyorrhoea and fungal infections of the skin. The present review article has been designed to elucidate data on phytochemistry, pharmacognostic characters and pharmacological activities associated with Terminali

Penggunaan Bahasa Rojak: Isu dan Cabaran dalam Memantapkan Kemahiran Komunikasi Pelajar di Kolej Kediaman UNIMAS

Dalam arus kemodenan yang pesat dengan kemajuan infrastruktur dan teknologi maklumat yang tiada sempadan wujud fenomena berbahasa yang pelbagai. Generasi muda khususnya pelajar terdedah dengan variasi berbahasa terkini daripada medium yang rencam. Institusi Pengajian Tinggi (IPT) berperanan penting dalam melahirkan graduan yang memenuhi kehendak pasaran dan berkeupayaan tinggi dalam bersaing pada peringkat lokal dan global. Kemahiran Insaniah yang disarankan oleh Kementerian Pengajian Tinggi Malaysia (KPTM) menerusi Modul Pembangunan Kemahiran Insaniah dilihat sangat membantu mengembangkan potensi dan mengasah kemahiran pelajar di universiti khususnya. Kertas kerja ini bertujuan memerihalkan isu dan cabaran dalam pemantapan kemahiran komunikasi dalam kalangan pelajar khususnya di kolej kediaman UNIMAS dengan memperlihatkan fenomena bahasa rojak yang menjadi salah satu trend berbahasa remaja. Oleh itu, kajian yang berbentuk deskriptif ini memanfaatkan kaedah temu bual yang melibatkan enam orang pelajar. Penelitian kajian dilihat berupaya menghasilkan data yang pelbagai dengan berfokuskan kepada percampuran kod yang menjadi kelaziman pertuturan dalam kalangan remaja khususnya pelajar universiti. Kertas kerja ini turut membincangkan implikasi kajian terhadap kemahiran komunikasi dalam kalangan pelajar yang akan menempuh dunia pekerjaan serta bersaing dalam memenuhi kehendak pasaran nasional dan global

Peranan Aktiviti-Aktiviti Kolej Dalam Pembangunan Kepimpinan: Sebuah Kajian Explorasi Pengalaman Pelajar di Kolej Kediaman UNIMAS

Pembangunan kepimpinan dalam kalangan pelajar merupakan salah satu aspek penting dalam kelangsungan tonggak pimpinan negara bangsa. Hal ini seiring dengan Pelan Strategik Pengajian Tinggi Negara (PSPTN) yang dirangka dengan visi nasional untuk mentransformasikan pengajian tinggi dalam memacu kecemerlangan dan kelestarian pembangunan modal insan minda kelas pertama khususnya dan pembangunan kepimpinan amnya. Oleh hal yang demikian, kolej-kolej kediaman universiti merupakan salah satu platform dalam mencorak dan membentuk pembangunan kepimpinan serta sahsiah pelajar yang dapat memenuhi keperluan pembangunan modal insan minda kelas pertama. Hal ini dapat dilihat menerusi penglibatan aktif pelajar-pelajar dalam aktiviti-aktiviti sama ada bersifat kolegiat atau yang berimpak tinggi seiring dengan gagasan PSPTN yang bermatlamat untuk membangunkan modal insan yang mempunyai keupayaan pengetahuan, kemahiran dan ciri-ciri peribadi yang unggul. Oleh itu, kajian ini memanfaatkan kaedah kualitatif dengan pendekatan fenomenologi bagi mengkaji peranan aktiviti-aktiviti kolej dalam pembangunan kepimpinan berdasarkan pengalaman pelajar-pelajar. Temu bual dijalankan secara mendalam (in-depth interview) melibatkan empat orang pelajar yang dipilih melalui purposive sampling dan data dianalisis menggunakan thematic analysis. Kaedah kajian ini dilihat berupaya menghasilkan data yang kaya dalam memperjelaskan serta memperhalusi pengalaman pelajar-pelajar dalam pembangunan kepimpinan di kolej kediaman. Kertas kerja ini turut membincangkan implikasi kajian terhadap pelajar-pelajar dan kolej kediaman secara spesifik dan universiti secara umum di samping mengemukakan cadangan-cadangan berkaitan peranan aktiviti-aktiviti kolej dalam pembangunan kepimpinan

Utilization of bedside ultrasound in the diagnosis and management of massive pulmonary embolism: a case report

AbstractThe prompt diagnosis and treatment of massive pulmonary embolism is a well-known challenge for physicians. We report a case of a 61-year-old hemodynamically unstable man who presented to the emergency department with complaints of acute dyspnea. After performing a focused history and physical, we used bedside ultrasound to diagnose significant right heart strain, which suggested massive bilateral pulmonary embolisms. This diagnosis was further supported by the visualization of deep venous thrombosis in the left lower extremity. The patient was treated with IV tissue plasminogen activator in the emergency department and survived to discharge in his usual state of health

Perovskite materials in X-ray detection and imaging: Recent progress, challenges, and future prospects

Perovskite materials have attracted significant attention as innovative and efficient X-ray detectors owing to their unique properties compared to traditional X-ray detectors. Herein, chronologically, we present an in-depth analysis of X-ray detection technologies employing organic-inorganic hybrids (OIHs), all-inorganic and lead-free perovskite material-based single crystals (SCs), thin/thick films and wafers. Particularly, this review systematically scrutinizes the advancement of the diverse synthesis methods, structural modifications, and device architectures exploited to enhance the radiation sensing performance. In addition, a critical analysis of the crucial factors affecting the performance of the devices is also provided. Our findings revealed that the improvement from single crystallization techniques dominated the film and wafer growth techniques. The probable reason for this is that SC-based devices display a lower trap density, higher resistivity, large carrier mobility and lifetime compared to film- and wafer-based devices. Ultimately, devices with SCs showed outstanding sensitivity and the lowest detectable dose rate (LDDR). These results are superior to some traditional X-ray detectors such as amorphous selenium and CZT. In addition, the limited performance of film-based devices is attributed to the defect formation in the bulk film, surfaces, and grain boundaries. However, wafer-based devices showed the worst performance because of the formation of voids, which impede the movement of charge carriers. We also observed that by performing structural modification, various research groups achieved high-performance devices together with stability. Finally, by fusing the findings from diverse research works, we provide a valuable resource for researchers in the field of X-ray detection, imaging and materials science. Ultimately, this review will serve as a roadmap for directing the difficulties associated with perovskite materials in X-ray detection and imaging, proposing insights into the recent status, challenges, and promising directions for future research

Quantum magnetism in the stripe phase: bond- versus site order

It is argued that the spin dynamics in the charge-ordered stripe phase might be revealing with regards to the nature of the anomalous spin dynamics in cuprate superconductors. Specifically, if the stripes are bond ordered much of the spin fluctuation will originate in the spin sector itself, while site ordered stripes require the charge sector as the driving force for the strong quantum spin fluctuations.Comment: 4 pages, 3 figures, LaTe

miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension.

Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor of patient survival, but links between endothelial miR-150 and vascular dysfunction are not well understood. We studied the effects of endothelial miR-150 supplementation and inhibition in PAH mice and cells from patients with idiopathic PAH. The role of selected mediators of miR-150 identified by RNA sequencing was evaluated in vitro and in vivo. Endothelium-targeted miR-150 delivery prevented the disease in Sugen/hypoxia mice, while endothelial knockdown of miR-150 had adverse effects. miR-150 target genes revealed significant associations with PAH pathways, including proliferation, inflammation, and phospholipid signaling, with PTEN-like mitochondrial phosphatase (PTPMT1) most markedly altered. PTPMT1 reduced inflammation and apoptosis and improved mitochondrial function in human pulmonary endothelial cells and blood-derived endothelial colony-forming cells from idiopathic PAH. Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression of pro-apoptotic, pro-inflammatory, and pro-fibrotic genes, including c-MYB, NOTCH3, transforming growth factor β (TGF-β), and Col1a1. In conclusion, we are the first to show that miR-150 supplementation attenuates pulmonary endothelial damage induced by vascular stresses and may be considered as a potential therapeutic strategy in PAH

The conceptual and practical ethical dilemmas of using health discussion board posts as research data.

Increasing numbers of people living with a long-term health condition are putting personal health information online, including on discussion boards. Many discussion boards contain material of potential use to researchers; however, it is unclear how this information can and should be used by researchers. To date there has been no evaluation of the views of those individuals sharing health information online regarding the use of their shared information for research purposes