Study of the red cell indices, hemogram and platelet variations in anaemic (

Background: Anemia is not a disease but it is the expression of underlying diseases and from the treatment point of view, it is necessary to identify the cause of anemia. The definition of anemia is as decrease in the number of red blood cells or the decreased percentage of hemoglobin in the blood. Anemia is such an important issue affecting a large population in India as well as worldwide, Hence, the present study was conducted to evaluate the red cell indices, haemogram and study the relation of platelet count with anaemia in anaemic (<10gm%) patients by automatic cell counter in Vikhe Patil Medical hospital.Methods: It was a prospective cross-sectional study. The sample size of research project was 100 patients, included according to the inclusion and exclusion criteria.Results: In present study, equal numbers of patients suffer from macrocytic normochromic anemia and hyperchromic anemia, that is, 8 patients of each. Out of 100 patients, 61% patients showed decreased platelet count. Maximum percentage of anaemic patients showed decreased platelet count in the range of 2.5-1.5 lakhs. Least percentage of patients (16%) showed platelet count less than 0.5 lakhs/cmm3.Conclusions: Screening for anaemia, treatment of anaemic women, and availability and use of food fortification (wheat flour with iron and folic acid), milk, sugar and salt with iron to build long term iron stores remains the key to reduce anemia in adolescent and pregnant women. Consumption of cheap iron-rich foodstuffs should be promoted. Effective poverty alleviation and hookworm prevention programs are also important

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Biological Potential of Tribulus terrestris

Plants have a significant role in preserving human health and improving quality of life. gokshura (Tribulus terrestris Linn.) one of such plants, is mentioned in Ayurvedic texts for various therapeutic properties like balya(strengthening),  brimhana (nutritive), rasayana(rejuvenator), mootrala(diuretic), shothahara(anti-inflammatory), vajikarana (aphrodisiac) etc. and useful in the management of mutrakrichhra (dysurea), ashmari (renal calculi) etc. It is a perennial plant, grown predominantly in India and Africa. Its extract contains alkaloids, saponins, resins, flavanoids and nitrates. As its therapeutic values, a review has been done to gather information on different aspects of gokshura. Further Ayurvedic references, the present paper also emphasizes on recent researches carried out on this plant for its pharmacological evaluation. Keywords: Tribulus terrestris, Diuretic, Pharmacolog

Transforaminal percutaneous endoscopic lumbar discectomy versus microdiscectomy: an Indian rural experience

Background: The objective of the study was to compare surgical outcome of micro-discectomy with transforaminal percutaneous endoscopic lumbar discectomy for single level lumbar disc herniation in Indian rural population.Methods: Retrospective comparative study was designed during the period of October 2012 to June 2015, patients in the age group of 22-75 years with unremitting sciatica with/without back pain, and/or a neurological deficit that correlated with appropriate level and side of neural compression as revealed on MRI, with single level lumbar disc herniation who underwent either microdiscectomy or TPELD were included in the study. Patients were assessed on visual analogue scale (VAS) for back and leg pain, modified macnabs criteria, the Oswestry Disability Index (ODI).Results: Group I (MD) included 44 patients and Group II (TPELD) included 20 patients. Significant improvement was seen in claudication symptom post-operatively in both MD and TPELD. Mean operating time was significantly shorter in MD group (1.11 hrs vs. 1.32 hrs; p<0.01). According to modified MacNab's criteria, outcome were excellent (81.8%), good (9.09%) and fair (9.09%) in MD. Similarly, in TPELD, 80%, 15% and 5% patients had excellent, good and fair outcome respectively. In both groups, no one had a poor outcome. Thus, overall success rate was 100% in the study.Conclusions: TPELD and MD have comparable post-operative outcome in most of the efficacy parameters in Indian rural patients undergoing treatment of single level lumbar disc herniation. Additionally, TPELD offers distinct advantages such as performed under local anaesthesia, preservation of structure, lesser post-operative pain and early mobilization and discharge from hospital

Studies on some free living protozoan from Salim Ali lake. Aurangabad

Protozoa are one-celled animals found worldwide in most habitats. Most species are free living, but all higher animals are infected with one or more species of protozoa. Infections range from asymptomatic to life threatening, depending on the species and strain of the parasite and the resistance of the host. Present study deals with the free living protozoa inhabiting fresh water bodies. The factor which influence their distribution and population in a given water bodies temperature, light, pH, chemical composition, acidity, and amount of food present in water and degree of adaptability of the individual protozoa to various environmental changes.&nbsp

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF MEGLUMINE IN BULK

UV, first, second and third derivative spectrophotometric methods have been developed for the determination of meglumine. The solutions of standard and sample were prepared in distilled water. For the first method i.e. calibration curve UV spectrophotometric method, the quantitative determination of the drug was carried at 254 nm and the linearity range was found to be 10 – 60 µg/ml. For the first, second, third derivative spectrophotometric methods the drug was determined at 247 nm, 216 nm, 266 nm with the linearity range 10 – 60 µg /ml. The calibration graphs constructed at their wavelength of determination were found to be linear for UV and derivative spectrophotometric methods. All the proposed methods have been extensively validated. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations

Study of interleukin-6 levels in early diagnosis of neonatal sepsis

Background:Neonatal septicemia is one of the commonest causes of neonatal mortality and morbidity. Interleukin-6 Levels appears to be one of the most promising candidate cytokine for early diagnosis of neonatal septicaemia. The aim and objectives of this study was to study the role of IL-6 levels as an early marker for diagnosis of neonatal sepsis and to compare IL-6 levels with other septic markers.  Methods:This is a hospital based prospective study to evaluate the efficacy of IL-6 as an early diagnostic marker of neonatal sepsis. Eighty neonates, delivered in the hospital, having risk factors for neonatal sepsis, along with those coming to hospital with signs and symptoms of sepsis up to 28 days of life (as study group ) along with normal new-borns admitted to the postnatal ward without high risk factors (control group) were enrolled for this study.Results:IL-6 Levels has shown maximum sensitivity of 95.83%, specificity of 87.50%, positive predictive value of 92%, negative predictive value of 93.33% and accuracy of 92.50 %. E. coli was the most common organism responsible for sepsis. CRP was reported to be highly sensitive (84.21%), and  CBC was highly specific (75.00%), IT ratio has sensitivity of 62.5% and specificity of 56.25% while micro-ESR has shown sensitivity of 50.0% and specificity of 62.5%. Out of 80 cases, blood culture (BacTalert) showed growth in 48 cases in study group while two cases in control group. Thus blood culture positivity was 60%.Conclusion:IL-6 test has maximum sensitivity as well as specificity in comparison with other septic markers. Blood culture is the gold standard for the diagnosis of septicemia. CRP is most sensitive while CBC is most specific marker in neonatal sepsis.

Grain Configuration of Solid Rocket Motor

The solid rocket motor upper stage for a space launch vehicle is a more efficient propulsion technology than the liquid rocket motor upper stage. Its grain design has the potential to be crucial in terms of lowering inert mass by adopting improved volume efficiency with the lowest practicable sliver size while keeping maximum strength. Specifically, the strategy for (3D) grain arrangement of the slot for the upper stage solid rocket engine has been described in this paper. The complex configuration is established by the design process, which takes place under a parametric model of geometry in (CAD) software and is typified by varied dynamics. When constructing solid propellant rocket motors, grain arrangement is a vital and critical step. Accurate estimates of grain geometric properties play a key role in performance prediction and can be a vital and critical stage in the design of solid propellant rocket motors. This research study proposes an effective performance-matching design framework for solid rocket motors that are tuned to suit a range of thrust performance criteria. The framework is constructed utilising an innovative and specialised general design technique that was designed to evaluate the general design parameters, which is given in this study. Because of the findings obtained, it can be stated that the recommended framework is a practical and efficient approach for solid rocket engine design and development

Micromachining of various metals by using Acidithiobacillus ferrooxidans 13820 culture supernatant experiments

a b s t r a c t The aim of the work reported in this paper is to develop a new method for micromachining of metals. This work demonstrates the potential use of bacterial culture supernatant for the machining of metals. The change in mass of various metals in bacterial culture supernatant was used to quantify the material removal rate. The promising results of present study revealed that the bacterial culture supernatant can be used as a replacement of the toxic FeCl 3 , currently employed for chemical machining. Also this research is important to optimize the formation of patterned copper films

Conceptual design of Blended Wing Body for Future Air Transportation

Blended wing body is a fixed wing aircraft which are smoothly blended together with no clear dividing line and no distinct wings also be given a wide Aerofoil shaped body. The future transportation is of aircrafts will incline towards the aerodynamically efficient and capable of carrying large number of passengers over long range and environmental benefits is the main paradigm in the design of aircraft BWB has a high lift to drag ratio which increases the CL max and velocity of the airplane with high load factor and high economy compared with traditional aircraft. Evacuation pressure or the cabin pressurization is the major issues in most of the designs with the minimum aerodynamic lift coefficient and drag coefficient. On the other side of the trend is towards the increasing cruise speed. High speed flow is connected with overcoming of intensive drag rise accruing due to existence of intensive shock, closing local area of supersonic flow. Increase of flight Mach number is possible only by using flow control methods and through affecting the shock increases of aspect ratio leads to increase of lift coefficient corresponding to maximal lift to drag. High bypass ratio engines have smaller fuel consumption and lower noise level but have negative effect on flow around airframe including take-off and landing phases. The necessity of solving problem of intensive aerodynamic heating of surface element of flight vehicles and by ensuring of their stability and controllability and also by need of implementing of high-volume tanks for hydrogen fuel and super high bypass ratio engines