ANТIGENS STRUCTURE OF ТНЕ PHYTOHEMAGGLUТININ OF PHASEOLUS VULGARIS

Phytohemagglutinins (РНА) are considered and utilized chiefly as antibodies in the field of experimental and аррlied medicine.Dujarrie de la Riuier and associates are the first to put in the problem as а matter of principle for the antigenic properties in the РНА and carry out experimental studies under this aspect.With renewed interest the question of the antigenic properties of РНА from Phaseolus vulgaris was raised after discovering its mitogenic abllity upon leukocytes of the human peripheric blооd in vitro. Pearmain and associates are the first to postulate the hypothesis that this phenomenon represents an immunological reaction of the leukocytes to the special РНА antigenic properties.We obtained РНА from the seeds of various types Phaseolus vulgaris, among which we chose the one with the most powerfully manifested mitogenetic properties. The РНА thus obtained represents purified globulin fractions, as already established bу the same authors in earlier investigations.Proving the antigenic structure of the РНА from Phaseolus vulgaris surges а particular scientific interest in the process of studying the essentials of its mitogenetic capacity. In our present work we give an account of the results btained from investigations on the antigenic structure of РНА of Phaseolus vulgaris. The experimentation was carried out in accordancewith the following plan: 1) determination of the antigenic structure of РНА from Phaseolus vulgaris, type Saxa and their identity with the antigens of РНА from the other sorts of this type; 2) determination of the antigens of РНА from Phaseolus vulgaris, sort Saxa and their related antigens in РНА obtained from the seeds of other sorts of the family Leguminosae - peas, soy-bean and hatchet.

IMMUNOBIOLOGICAL AND ELECTROPHOREТIC INVESТIGAТJONS ON PHYTOHEMAGGLUТININS IN ТНЕ SEEDS OF SOME BULGARIAN PLANT SORTS

In the past two decades the scientific interiest in antibodies of plant origin was substantially increased. This is due to the discovering of а vast number of specific phytohemagglutinins as well as to other interesting biological properties of the same, namely their capacity of stimulating the mitotic activity of certain cells, of inhibiting the action of certain -enzymes, of arresting the development of some tumourous cells in vitro etc.Moreover, plant antibodies represent very suitble, samples for carrying out а thorough study on immunological, biochemical and biophysical properties of the immune bodies in general.In the present we report the results of our investigation on certain immunological and biochemical properties of phytohemagglutinins, extracted from the seeds of the sort Phaseolus vulgaris (beans sort 4784, 4579, 4540), Soja hispida (soya bean sort Adams, soya sort “granular"), Pisum sativum (peas sort Ramonski and peas Peremiden), Lathirus aphaca (hatchet Taldjer)

ANTIGENIC UNITY BETWEEN PHYTOHEMAGGLUTININ OF PHASEOLUS VULGARIS AND SOME BACTERIA AND VIRA

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