23 research outputs found
THE EFFECT OF XEXACHLOROCYCLOHEXANE (HCH) ISOMERS ON THE DEVELOPMENT OF GENETIC CHANGES IN MAMMALIAN CELLS
Effect of O-isopropoxyphenyl-N-methylcarbamate (propoksur) on the embryonal development of mice
Effect of simultaneous administration of ddt on the toxicity of dimethylnitrosoamine in rats in long-term experiment
Mutagenic action of N-nitroso derivatives of carbamate insecticides (carbaryl and propoksur) on mammalian cells
Changes in cholinesterase and carboxylesterase activity in rat effected by enolophosphate insectides IPO-63 and IPO-597
Is concentration and motility of male gametes related to DNA damage measured by comet assay?
Two generation reproductive and developmental toxicity following subchronic exposure of pubescent male mice to di(2-ethylhexyl)phthalate
Di-(2-ethylhexyl)phthalate (DEHP) is widely present in the human environment.
The study aimed at the investigation of potential genotoxic effects induced by subchronic exposure to DEHP in germ cells
of male mice in the first period of puberty, and to check if the transmission of mutation to the next generation via the sperm
is possible. 8-weeks exposure to 2,000 mg/kg and 8,000 mg/kg of DEHP diminished sperm count and quality, leading to a
reduced percentage of pregnant females mated to exposed males. A slight increase in the frequency of prenatal deaths and
dominant lethal mutations, as well as a significantly increased percentage of abnormal skeletons among the F1 offspring
of males exposed to 8,000 mg/kg of DEHP, were observed. Exposure of the fathers did not cause a delay in the postnatal
development of the offspring, except for fur development in the group of 8,000 mg/kg of DEHP. Gametes of male offspring
of exposed fathers showed reduced motility. The results may suggest that diminished spermaozoa quality induced by DEHP
may be coincidental with mutations leading to intrauterine deaths and skeletal abnormalities in the offspring