Primary Localized Amyloidosis of the Ureter with Osseous Metaplasia Presenting as a Suspicious Ureteral Mass

Primary amyloidosis of the ureter is a rare disease that is difficult to distinguish from urothelial carcinoma. Only 50 cases of primary ureter amyloidosis have been reported since it was first described in 1937. Of these, only five cases of ureter amyloidosis with osseous metaplasia were reported. In this study, we report the clinical presentation of ureter primary amyloidosis that presented as a mass with osseous metaplasia. The aim of this study is to provide clinicians with knowledge about the clinical/radiologic manifestation that raise the suspicion of amyloidosis, bearing in mind the importance of differentiating it from other malignant processes

Primary Peritoneal Angiosarcoma Metastatic to Liver and Bone without History of Radiation Therapy

Angiosarcoma is a rare vascular soft tissue tumor of endothelial origin most commonly seen in the elderly as a primary cutaneous head and neck malignancy. Furthermore, a peritoneal angiosarcoma is an exceedingly rare entity. This is the second case of primary peritoneal angiosarcoma reported in literature that is not associated with prior radiotherapy. Herein, we describe a case of primary peritoneal angiosarcoma metastatic to both the liver and bone in a male patient with metachronous renal cell carcinoma and parathyroid adenoma

An Inguinal Perivascular Epithelioid Cell Tumor Metastatic to the Orbit

Malignant PEComas are rare mesenchymal neoplasms. These tumors harbor distinct myomelanocytic phenotype. The PEComa family of tumors includes lymphangioleiomyomatosis, angiomyolipoma, clear cell sugar tumor of the lung, and myomelanocytic tumor of the falciparum ligament/ligamentum teres. PEComas have no known normal cell counterpart. Majority of PEComas are benign and occur predominantly in the middle-age women. These tumors are commonly encountered in the uterus. Herein, we report a 20-year-old woman with a left inguinal mass metastatic to orbit, brain, lumbar spine, and skin at presentation. To our knowledge, this is the first case of metastatic PEComa to the orbit. This is the third case of primary PEComa of the inguinal area

Primary urinary bladder angiosarcoma with ascites

Non-urothelial tumors of the urinary bladder are rare. Sarcomas constitute less than 1% of all malignant neoplasms and angiosarcomas comprise 2% of all sarcomas [1]. We report a case of a 69-year old male with history of a low-grade prostatic adenocarcinoma for which he underwent external beam radiation therapy in 1/2010. He presented to the ER in 9/2015 with an abdominal distension and urinary retention and was found to have malignant ascites, hydronephrosis and a urinary bladder mass. Pathologic evaluation of the ascites and urinary bladder tumor revealed metastatic epithelioid angiosarcoma. Since the patient presented with an advanced stage inoperable disease, chemotherapy was initiated shortly thereafter. Unfortunately, the patient became septic and died 6 weeks following the original diagnosis. Keywords: Urinary bladder neoplasms, Epithelioid angiosarcoma, Postirradiation-associated sarcom

GATA3 expression in pulmonary mucinous adenocarcinoma presenting as a distant metastasis: A case report

A 75-year-old female with 50 pack-year history of smoking was found to have a right upper lobe adenocarcinoma with metastatic soft tissue chest wall deposit. The tumor’s immunohistochemical profile at both sites was significant for expression of CK7 and GATA3, but not TTF1 and Napsin A. Furthermore, by next generation sequencing the tumor harbored concurrent KRAS G12A and BRAF D594H mutations and had no alterations in ERBB2 gene. Our case is unique as this unusual immunoprofile with GATA3 expression that is preferentially expressed in breast and urothelial carcinomas was observed in mucinous adenocarcinoma of the lung presenting as a distant metastasis