Structural differences in amyloid-β fibrils from brains of non-demented elderly individuals and Alzheimer's disease patients

Although amyloid plaques composed of fibrillar amyloid-β (Aβ) assemblies are a diagnostic hallmark of Alzheimer's disease (AD), quantities of amyloid similar to those in AD patients are observed in brain tissue of some nondemented elderly individuals. The relationship between amyloid deposition and neurodegeneration in AD has, therefore, been unclear. Here, we use solid-state NMR to investigate whether molecular structures of Aβ fibrils from brain tissue of nondemented elderly individuals with high amyloid loads differ from structures of Aβ fibrils from AD tissue. Two-dimensional solid-state NMR spectra of isotopically labeled Aβ fibrils, prepared by seeded growth from frontal lobe tissue extracts, are similar in the two cases but with statistically significant differences in intensity distributions of cross-peak signals. Differences in solid-state NMR data are greater for 42-residue amyloid-β (Aβ42) fibrils than for 40-residue amyloid-β (Aβ40) fibrils. These data suggest that similar sets of fibril polymorphs develop in nondemented elderly individuals and AD patients but with different relative populations on average

Spin Transition in Strongly Correlated Bilayer Two Dimensional Electron Systems

Using a combination of heat pulse and nuclear magnetic resonance techniques we demonstrate that the phase boundary separating the interlayer phase coherent quantum Hall effect at $\nu_T = 1$ in bilayer electron gases from the weakly coupled compressible phase depends upon the spin polarization of the nuclei in the host semiconductor crystal. Our results strongly suggest that, contrary to the usual assumption, the transition is attended by a change in the electronic spin polarization.Comment: 4 pages, 3 postscript figur

Korringa ratio of ferromagnetically correlated impure metals

The Korringa ratio, $\cal K$, obtained by taking an appropriate combination of the Knight shift and nuclear spin-lattice relaxation time, is calculated at finite temperature, $T$, in the three-dimensional electron gas model, including the electron-electron interaction, $U$, and non-magnetic impurity scatterings. $\cal K$ varies in a simple way with respect to $U$ and $T$; it decreases as $U$ is increased but increases as $T$ is raised. However, $\cal K$ varies in a slightly more complicated way with respect to the impurity scatterings; as the scattering rate is increased, $\cal K$ increases for small $U$ and low $T$, but decreases for large $U$ or high $T$ regime. This calls for a more careful analysis when one attempts to estimate the Stoner factor from $\cal K$.Comment: 7 pages including 3 figures. To be published in Phys. Rev. B, Dec.

Resistance spikes and domain wall loops in Ising quantum Hall ferromagnets

We explain the recent observation of resistance spikes and hysteretic transport properties in Ising quantum Hall ferromagnets in terms of the unique physics of their domain walls. Self-consistent RPA/Hartree-Fock theory is applied to microscopically determine properties of the ground state and domain-wall excitations. In these systems domain wall loops support one-dimensional electron systems with an effective mass comparable to the bare electron mass and may carry charge. Our theory is able to account quantitatively for the experimental Ising critical temperature and to explain characteristics of the resistive hysteresis loops.Comment: 4 pages, 3 figure

Pairing in the quantum Hall system

We find an analogy between the single skyrmion state in the quantum Hall system and the BCS superconducting state and address that the quantum mechanical origin of the skyrmion is electronic pairing. The skyrmion phase is found to be unstable for magnetic fields above the critical field $B_{c}(T)$ at temperature $T$, which is well represented by the relation $B_c(T)/B_{c}(0) \approx {[1-(T/T_c)^3]}^{1/2}$.Comment: revtex, two figures, to appear in Phys. Rev. B (Rapid Communications

Critical Behavior of Nuclear-Spin Diffusion in GaAs/AlGaAs Heterostructures near Landau Level Filling \nu=1

Thermal measurements on a GaAs/AlGaAs heterostructure reveal that the state of the confined two-dimensional electrons dramatically affects the nuclear-spin diffusion near Landau level filling factor \nu=1. The experiments provide quantitative evidence that the sharp peak in the temperature dependence of heat capacity near \nu=1 is due to an enhanced nuclear-spin diffusion from the GaAs quantum wells into the AlGaAs barriers. We discuss the physical origin of this enhancement in terms the possible Skyrme solid-liquid phase transition.Comment: 1 LateX file, 3 figures, submitte

A suggested search for 207Pb nuclear Schiff moment in PbTiO3 ferroelectric

We suggest two types of experiments, NMR and macroscopic magnetometry, with solid PbTiO3 to search for the nuclear Schiff moment of 207Pb. Both kinds of experiments promise substantial improvement over the presently achieved sensitivities. Statistical considerations show that the improvement of the current sensitivity can be up to 10 orders of magnitude for the magnetometry experiment and up to 6 orders of magnitude for the NMR experiment. Such significant enhancement is due to the strong internal electric field of the ferroelectric, as well as due to the possibility to cool the nuclear-spin subsystem in the compound down to nanokelvin temperatures.Comment: 4 pages; revised sensitivity estimate for NMR experimen

Skyrmions in quantum Hall ferromagnets as spin-waves bound to unbalanced magnetic flux quanta

A microscopic description of (baby)skyrmions in quantum Hall ferromagnets is derived from a scattering theory of collective (neutral) spin modes by a bare quasiparticle. We start by mapping the low lying spectrum of spin waves in the uniform ferromagnet onto that of free moving spin excitons, and then we study their scattering by the defect of charge. In the presence of this disturbance, the local spin stiffness varies in space, and we translate it into an inhomogeneus metric in the Hilbert space supporting the excitons. An attractive potencial is then required to preserve the symmetry under global spin rotations, and it traps the excitons around the charged defect. The quasiparticle now carries a spin texture. Textures containing more than one exciton are described within a mean-field theory, the interaction among the excitons being taken into account through a new renormalization of the metric. The number of excitons actually bound depends on the Zeeman coupling, that plays the same role as a chemical potencial. For small Zeeman energies, the defect binds many excitons which condensate. As the bound excitons have a unit of angular momentum, provided by the quantum of magnetic flux left unbalanced by the defect of charge, the resulting texture turns out to be a topological excitation of charge 1. Its energy is that given by the non-linear sigma model for the ground state in this topological sector, i.e. the texture is a skyrmion.Comment: 17 pages, 1 figur

Anisotropy of Magnetoresistance Hysteresis around the ν=2/3\nu=2/3 Quantum Hall State in Tilted Magnetic Field

We present an anisotropy of the hysteretic transport around the spin transition point at Landau level filling factor $\nu=2/3$ in tilted magnetic field. When the direction of the in-plane component of the magnetic field $B_{\parallel}$ is normal to the probe current $I$, a strong hysteretic transport due to the current-induced nuclear spin polarization occurs. When $B_{\parallel}$ is parallel to $I$, on the other hand, the hysteresis almost disappears. We also demonstrate that the nuclear spin-lattice relaxation rate $T_{1}^{-1}$ at the transition point increases with decreasing angle between the directions of $B_{\parallel}$ and $I$. These results suggest that the morphology of electron spin domains around $\nu =2/3$ is affected by the current direction.Comment: 4 pages, 4 figure