Various mechanical ventilation techniques have been investigated, both
experimentally and clinically, to improve outcome from acute respiratory failure. As an
alternative means of respiratory support, perfluorocarbon (PFC) liquids have gained
Interest first in liquid breathing applications, and then have formed the basis for the liquid
ventilation technique.
Combining the liquid and gas ventilation techniques, a new ventilatory support
technique, namely partial liquid ventilation, is In progress as an investigational treatment
modality in which gas tidal ventilation is superimposed on PFC-treated lungs.
This thesis consists of six articles focusing on this topic. One review and five
articles describing original experimental work on partial liquid ventilation are presented.
Partial liquid ventilation is Investigated with respect to its effects on pUlmonary gas
exchange and respiratory system mechanics in an animal model of acute respiratory
failure and in healthy animals.
Various mechanical ventilation techniques have been investigated, both
experimentally and clinically, to improve outcome from acute respiratory failure. As an
alternative means of respiratory support, perfluorocarbon (PFC) liquids have gained
Interest first in liquid breathing applications, and then have formed the basis for the liquid
ventilation technique.
Combining the liquid and gas ventilation techniques, a new ventilatory support
technique, namely partial liquid ventilation, is In progress as an investigational treatment
modality in which gas tidal ventilation is superimposed on PFC-treated lungs.
This thesis consists of six articles focusing on this topic. One review and five
articles describing original experimental work on partial liquid ventilation are presented.
Partial liquid ventilation is Investigated with respect to its effects on pUlmonary gas
exchange and respiratory system mechanics in an animal model of acute respiratory
failure and in healthy animals