7 research outputs found
Maternal undernutrition model of two generations of rats: Changes in the aged retina
The impact of maternal undernutrition on
morphological changes of the retina was assessed in two
generations of aged offspring. Wistar 18 rats (9 of each
generation of 20-month-old female offspring; in total
-27 eyes) were analyzed. The first generation offspring
were born to mothers who: (a) were restricted to food
only before pregnancy (pre-pregnancy); (b) whose food
was restricted before and during pregnancy. The control
group and all the offspring were fed normally. After
enucleating the eyes, paraffin sections were stained with
hematoxylin and eosin. The thickness of retina layers
was measured. Cryosections were immunostained using
glial fibrillary acidic protein, ionized calcium-binding
adaptor molecule1, RNA-binding protein with multiple
splicing for evaluation of macroglia, microglia and
retinal ganglion cells by digital image analysis tools. Our
data have shown atrophy of photoreceptor layer and
degeneration of outer nuclear layer in all investigated
groups, but less damage was found in the control group.
Higher Müller cell activity and greater number of
microglial cells was observed in the second generation
offspring born from both restricted diet groups. Higher
numbers of microglial and retinal ganglion cells were
observed in the second generation in comparison to the
first generation offspring. Malnutrition of the mother
may be one of the possible causes of degeneration of the
outer layers of the retina and activation of Müller cells in
the second generation offspring. The effect of maternal
nutritional restriction on the number of microglial and
retinal ganglion cells is unclea
Diversity in auxology: between theory and practice. Proceedings of the 18th Aschauer Soiree, 13th November 2010
Auxology has developed from mere describing child and adolescent growth into a vivid and interdisciplinary research area encompassing human biologists, physicians, social scientists, economists and biostatisticians. The meeting illustrated the diversity in auxology, with the various social, medical, biological and biostatistical aspects in studies on child growth and development
Adolescent growth: Genes, hormones and the peer group
The association between poverty, malnutrition, illness and poor socioeconomic conditions on the one side, and poor growth and short adult stature on the other side, is well recognized. Yet, the simple assumption by implication that poor growth and short stature result from poor living conditions, should be questioned. Recent evidence on the impact of the social network on adolescent growth and adult height further challenges the traditional concept of growth being a mirror of health. Twenty-nine scientists met at Glücksburg castle, Northern Germany, November 15th - 17th 2013, to discuss genetic, endocrine, mathematical and psychological aspects and related issues, of child and adolescent growth and final height
Adolescent growth: genes, hormones and the peer group. Proceedings of the 20th Aschauer Soiree, held at Glücksburg castle, Germany, 15th to 17th November 2013
The association between poverty, malnutrition, illness and poor socioeconomic conditions on the one side, and poor growth and short adult stature on the other side, is well recognized. Yet, the simple assumption by implication that poor growth and short stature result from poor living conditions, should be questioned. Recent evidence on the impact of the social network on adolescent growth and adult height further challenges the traditional concept of growth being a mirror of health. Twenty-nine scientists met at Glücksburg castle, Northern Germany, November 15th - 17th 2013, to discuss genetic, endocrine, mathematical and psychological aspects and related issues, of child and adolescent growth and final height. <br/> <br/>