Unfolding the Pharmacokinetic and Exposure Variability from Overall Interindividual Variability for 1,2,3,4,6,7,8,9-Octachlorodibenzo-ρ-Dioxin (OCDD) and Mercury

There is variability in the level of environmental chemicals in individual's bodies. This variability is composed of exposure variability and pharmacokinetic parameter variability. In the present study, two compounds, 1,2,3,4,6,7,8,9-cctachlorodibenzo-ρ-dioxin (OCDD) and mercury, were examined. Data from the National Health and Nutrition Examination Survey (NHANES) were used to represent overall variability. Models were used to predict pharmacokinetic variability. The variability in exposure was unfolded from the pharmacokinetic variability and the contribution of each type of variability to overall variability was determined. The results showed that most of the overall variability observed was due to exposure variability.Master of Science in Public Healt