Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae.

The Bay of Bengal is known as the epicenter for seeding several devastating cholera outbreaks across the globe. Vibrio cholerae, the etiological agent of cholera, has extraordinary competency to acquire exogenous DNA by horizontal gene transfer (HGT) and adapt them into its genome for structuring metabolic processes, developing drug resistance, and colonizing the human intestine. Antimicrobial resistance (AMR) in V. cholerae has become a global concern. However, little is known about the identity of the resistance traits, source of AMR genes, acquisition process, and stability of the genetic elements linked with resistance genes in V. cholerae Here we present details of AMR profiles of 443 V. cholerae strains isolated from the stool samples of diarrheal patients from two regions of India. We sequenced the whole genome of multidrug-resistant (MDR) and extensively drug-resistant (XDR) V. cholerae to identify AMR genes and genomic elements that harbor the resistance traits. Our genomic findings were further confirmed by proteome analysis. We also engineered the genome of V. cholerae to monitor the importance of the autonomously replicating plasmid and core genome in the resistance profile. Our findings provided insights into the genomes of recent cholera isolates and identified several acquired traits including plasmids, transposons, integrative conjugative elements (ICEs), pathogenicity islands (PIs), prophages, and gene cassettes that confer fitness to the pathogen. The knowledge generated from this study would help in better understanding of V. cholerae evolution and management of cholera disease by providing clinical guidance on preferred treatment regimens.DBT Indi

A note on constacyclic and skew constacyclic codes over the ring Zp[u,v]/⟨u2−u,v2−v,uv−vu⟩\mathbb{Z}_{p} [u,v]/\langle u^2-u,v^2-v,uv-vu\rangle

For odd prime $p$, this paper studies $(1+(p-2)u)$-constacyclic codes over the ring $R= \mathbb{Z}_{p} [u,v]/\langle u^2-u,v^2-v,uv-vu\rangle$. We show that the Gray images of $(1+(p-2)u)$-constacyclic codes over $R$ are cyclic and permutation equivalent to a quasi cyclic code over $\mathbb{Z}_{p}$. We derive the generators for $(1+(p-2)u)$-constacyclic and principally generated $(1+(p-2)u)$-constacyclic codes over $R$. Among others, we extend our results for skew $(1+(p-2)u)$-constacyclic codes over $R$ and exhibit the relation between skew $(1+(p-2)u)$-constacyclic codes with the other linear codes. Finally, as an application of our study, we compute several non trivial linear codes by using the Gray images of $(1+(p-2)u)$-constacyclic codes over this ring $R$

Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020

This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India. Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-