The Ursinus Weekly, February 13, 1975

Forum will host Jessica Savitch • Lorelei: Midnite at the oasis • Forum review: Morgenthau delivers informative address on complex topic • Classics performed by Temple orchestra • U.C. Chaplain plans Lenten experiences • Purloined pitchers • Music groups active • Phlash! • Interaction between Ursinus past and present • We place ourselves at your disposal • 1975 interview schedule • The old gold remains • New addition to education faculty • The travails of Knorft • Millions for Ursinus • Bears beat Hopkins; Lose to Muhlenberg • Hockey team returns with memories of Great Britain • Spring flicks at Union • Girls\u27 basketball • Distinguished wrestler named coach • Swimmers splash alonghttps://digitalcommons.ursinus.edu/weekly/1029/thumbnail.jp

The Ursinus Weekly, October 4, 1973

Freshman class energetic; Brings new atmosphere to U.C. • Open dorm extension refused, frosh cuts limited to 6 • Bomberger Hall finally opens after lengthy renovations • Professor publishes • Union plans discussed • Editorial: And the train keeps a-rollin’ • Philadelphia Folk Festival presents music and workshops • Letter to the editor: Give us a chance • Presenting Mr. Gaglio • U.C. coeds travel to France • Hockey Bearettes on their way to successful season • Hopeful hoopla • New tennis courts ready for use • Bears drop twohttps://digitalcommons.ursinus.edu/weekly/1000/thumbnail.jp

The Ursinus Weekly, April 25, 1974

Jeane Dixon arrives at Ursinus College • Bruce Springsteen and band a big hit in Helfferich at first major rock music concert at Ursinus • Editorial staff named for Ursinus Weekly • Two more forums planned for April • IRC participates in Model UN • Committee meets on women’s hours • Editorial: Does anybody really care? • Jeane Dixon: Before it all happened • Union’s learn-ums: Mini-courses galore • Volunteers help special students • C. Vaughn Fitzgerald meets the challenge of London culture and energy crisis • Gutman speaks to Ec club • Freshman Mark Sellers new college chess champ • Travelin’ 7 benefits Pierce scholarship fund • The Zodiac: The water signs: Cancer, Scorpio, Pisces • Songfest slated for April 30 • Women’s Lacrosse hosts “all college” tri-outs • U.C. runs awayhttps://digitalcommons.ursinus.edu/weekly/1014/thumbnail.jp

The Ursinus Weekly, March 22, 1973

U.S.G.A. takes action on several matters • C.C.C. slots filled for coming autumn • Fifteen Japanese students to arrive at Ursinus for Summer session • Physical Education Department expands freshman course to fit facilities • Dean R.J. Whatley institutes new property damage procedure • Moore\u27s military miniatures march into class • Editorial: The tax game • Focus: Tom Sturgeon • Follow the bouncing ball • Right before your eyes we have Loot, an obscure comedy by Joe Orton • A meeting of Eastern and Western cultures; U.C. students offer international perspectives • A night on Broadway with Elmer • Songfest reviewed; or Campus notes • Former Kilt Klad columnist stirred by athletic changes • Sports book review: The Athletic revolution by Jack Scott • Sports buffs cornerhttps://digitalcommons.ursinus.edu/weekly/1101/thumbnail.jp

The Ursinus Weekly, February 28, 1974

Dean of men’s office ransacked, washing machines destroyed as vandalism continues: USGA proposes community action to eliminate problem • Sorority bids signed; sophomore girls join three campus groups • Christian fellowship will present musical program • First concert scheduled for Helfferich Hall • St. Andrew’s Society announces deadline for scholarships • Editorials: Festival of the Arts; On vandalism • Alumni corner: Leidy lacks leisure • Forum review: Yass Hakoshima • Drama review: “This is the Rill speaking” and “The Interview” • I.F. Winter Party scheduled March 8 • Woodstock abdication • Bearettes come back! • It was a very good year! • First gymnastics meet takes placehttps://digitalcommons.ursinus.edu/weekly/1011/thumbnail.jp

KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor

Kinesin-mediated membrane trafficking is a fundamental cellular process, but its developmental relevance is little understood. Here we show that the kinesin-3 motor KIF16B/Rab14 complex acts in biosynthetic Golgi-to-endosome traffic of the fibroblast growth factor receptor (FGFR) during early embryonic development. Kif16b(-/-) mouse embryos failed in developing epiblast and primitive endoderm lineages and died in the pen-implantation stage, similar to previously reported FGFR2 knockout embryos. KIF16B associated directly with the Rab14-GTP adaptor on FGFR-containing vesicles and transported them toward the plasma membrane. To examine whether the nucleotide state of Rab14 serves as a switch for transport, we performed Rab14-GDP overexpression. This dominant negative approach reproduced the whole putative sequence of KIF16B or FGFR2 deficiency: impairment in FGFR transport, FGF signaling, basement membrane assembly by the primitive endoderm lineage, and epiblast development. These data provide one of the first pieces of genetic evidence that microtubule-based membrane trafficking directly promotes early development