2 research outputs found
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
- Author
- Abecasis G.R. (Gonçalo)
- Altshuler D. (David)
- Assimes T.L. (Themistocles)
- Auer P. (Paul)
- Ballantyne C. (Christie)
- Bis J.C. (Joshua)
- Bizon C. (Chris)
- Boehnke M. (Michael)
- Boerwinkle E.A. (Eric)
- Borecki I.B. (Ingrid)
- Bottinger E.P. (Erwin)
- Carlson C.S. (Christopher)
- Chen Y.E. (Y. Eugene)
- Correa D.D.
- Crosby S.
- Crosslin D.R. (David)
- Cupples L.A. (Adrienne)
- Do R. (Ron)
- Duan Q. (Qing)
- Duijn C.M. (Cornelia) van
- Durda P. (Peter)
- Farlow D.N. (Deborah)
- Feitosa M.F. (Mary Furlan)
- Flannick J. (Jason)
- Folsom A.R. (Aaron)
- Fornage M. (Myriam)
- Fox E.R. (Ervin)
- Franceschini N. (Nora)
- Fuchsberger C. (Christian)
- Gabriel S.B. (Stacey)
- Gaulton K. (Kyle)
- Gottesman R.F. (Rebecca)
- Griswold M.D. (Michael)
- Groop L. (Leif)
- Gudnason V. (Vilmundur)
- Hayward C. (Caroline)
- Hofman A. (Albert)
- Holmen O.L. (Oddgeir)
- Hu Y. (Youna)
- Huffman J.E. (Jennifer)
- Hveem K. (Kristian)
- Isaacs A.J. (Aaron)
- Jackson R.D. (Rebecca)
- Jakobsdottir M. (Margret)
- Jarvik G.P. (Gail)
- Jiao S. (Shuo)
- Jun Y. (Yang)
- Kang H.M. (Hyun Min)
- Kathiresan S. (Sekar)
- Kooperberg C. (Charles)
- Lange E.M. (Ethan)
- Lange L.A. (Leslie)
- Levy D. (Daniel)
- Li K.-P. (Kuo-Ping)
- Li Y. (Yun)
- Lin D.Y. (Dan)
- Lindgren C.M. (Cecilia)
- Locke A. (Adam)
- Loos R.J.F. (Ruth)
- Lu Y. (Yingchang)
- Lumley T. (Thomas)
- Manning A.K. (Alisa)
- Martin L.W. (Lisa)
- McCarthy M.I. (Mark)
- Meitinger T. (Thomas)
- Nickerson D.A. (Deborah)
- North K.E. (Kari)
- O'Donnell C.J. (Christopher)
- Peloso G.M. (Gina)
- Peters U. (Ulrike)
- Post W.S. (Wendy S.)
- Psaty B.M. (Bruce)
- Reiner A. (Alexander)
- Rich S.S. (Stephen)
- Rieder M. (Mark)
- Rivas M.A. (Manuel)
- Robinson J.G. (Jennifer)
- Rosenthal E.A. (Elisabeth)
- Rotter J.I. (Jerome)
- Rudan I. (Igor)
- Ruderfer D. (Douglas)
- Schmidt E.M. (Ellen)
- Schreiner P.J. (Pamela)
- Sim X. (Xueling)
- Siscovick D.S. (David)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Stahl E.A. (Eli)
- Sætrom P. (PĂ¥l)
- Tang Z.-Z. (Zheng-Zheng)
- Taylor H.A. (Herman)
- Tracy R.P. (Russell)
- Tsai M.Y. (Michael)
- Turner E.H. (Emily)
- Uitterlinden A.G. (André)
- Wassel C.L. (Christina)
- Willer C.J. (Cristen)
- Wilson J.G. (James)
- Xue C. (Chenyi)
- Zhang H. (He)
- Zhang J. (Ji)
- Zhang Q. (Qunyuan)
- Publication venue
- 'Elsevier BV'
- Publication date
- 06/02/2014
- Field of study
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98th or <2nd percentile). Follow-up analyses included sequencing of 1,302 additional individuals and genotype-based analysis of 52,221 individuals. We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previous
Annual Selected Bibliography
- Author
- Abraham George Chackulathu
- Abraham Thomas
- Abu-Saad Huda
- Ade George
- Ah-Tye Howard
- Albin Lindq Elaine
- Aleinikoff
- Allan Andrew T
- Allen Rebecca
- Almaguer Tomas
- Almirol Edwin
- Anderson Robert N
- Anh Nguyen T
- Area PilipinoAmericanWriters
- Arter
- Ascher Carol
- Bach Robert L
- Baker S.R.
- Bang Heeduk
- Bannai Hideko
- Bautista Caranto
- Beechert Edward D
- Bell D.A.
- Bell Roger
- Bennett D.
- Berssenbrugge
- Bhatt A.K.
- Bolaria B.
- Bolaria Singh
- Borjas George J
- Borjas George J
- Bourier Leon E
- Bouslog Ann Mikiko
- Brainard Cecilia Manguerra
- Brien David
- Browne Blaine Terry
- Buck Elizabeth Bentzel
- Burrin Dale
- Burton Jack
- Butcher Philip
- Caces Maria Fe E
- California State Post-secondary Education Commission
- California State Post-secondary Education Commission
- Callies
- Calvin John Edward
- Caplan Nathan
- Card Josefina Jayme
- Carlson Alvar W
- Carlson Ronald Gaylord
- Cattell Raymond B
- Chadney James G
- Chai Alice Yun
- Chai Yun
- Chan Sucheng
- Chandrasekhar S.
- Chang Betty L
- Chang Diana
- Chang Edward Tea
- Chang Joseph S
- Chapin Helen G
- Cheng
- Cheung K.K.
- Cheung King Kok
- Ching-Hwang Yen
- Cho Chang Kuk
- Cho Kun-Kap
- Chock Eric
- Christgau John
- Chu-Luu
- Chung Dae Kyun
- College Entrance Examination Board.
- Collins Donald E
- Cortes Carlos E
- Cuellar B.
- Cullinane Michael
- Current Hawaiiana
- Cushing Robert L
- Daniels Roger
- Dasgupta Sathi Sengupta
- Day A.
- Denker The Chinese
- Department of the Interior.
- Department of the Interior.
- Desbarats Jacqueline
- Dickinson Anne E
- Din Grant
- Dixit Jiwan Lata
- Dowie
- Downing Douglas Charles
- Du Tu Le Tho
- Duncan Sharon E
- Edelman Sandra
- Elgie Kae
- Embrey Sue Kunitomi
- Emilio Frances
- Enrado Patricia
- Evaluation Services
- Evangelista Susan
- Fa Angie
- Faller H.S.
- Families Nash
- Feldman K.W.
- Fessler Loren W
- Field Anne
- Filson Brent
- Finnan Christine R
- Flaskerud Jacquelyn H
- Floyd Candace
- Forbes Susan S
- Foster Sesshu
- Fox Raymond
- Franks Joel S
- Fugita Stephen S
- Fujii E.T.
- Fujimura Bunya
- Fujisaki Lance
- Funabiki Kiku Hori
- Gapp Frank W
- Garcia Mila A
- Gerber L.M.
- Geschwender James A
- Gibson Robert E
- Glazer Nathan
- Glenn Evelyn Nakano
- Grant MOM M
- Grimshaw Patricia
- Haines David W
- Hamilton Janice
- Han Yanghui Kim
- Hansen Arthur A
- Harewood Wayne R
- Harris Mark J
- Harrison Brian R
- Harstad James
- Havighurst Robert J
- Hawaii Women's History Historians Committee
- HawaiiState Department
- Hayashi Brian Masaru
- Hayes Peter
- Hemmila Herbert Williim
- Hendricks Glenn
- Henkin William A
- Herranen Mark Henry
- Herzig John A
- Hill Herbert
- Hirabayashi Gordon
- Hirschman Charles
- Hojat Mohammadreza
- Hom Marlon K
- Honma Dean H
- Hoshino Edith
- Houston
- Howe K. R.
- Hsu Tsung-Kuo
- Hune Shirley
- Hyams B.K.
- Hyun John K
- Hyun Peter
- Ikels Charlotte
- Inada Lawson
- Infante
- Irons Peter
- Isscl William
- Ito
- Jackson Peter
- James T.
- Japanese American Curriculum Project Japanese
- Joesting Edward
- Johnson Giff
- Johnson Patricia A.
- Johnson Ronald C
- Johnson S.W.
- Joyce Richard E
- Juhasz Suzanne
- Jun
- Kageyama Yuri
- Kahn Joan Rae
- Kambayashi Makimi
- Kanahele George Hu'en
- Kanost Richard E
- Kashiwazaki H.
- Kawaguchi Lorraine Megumi
- Kawano Roland
- Kent Noel
- Kern R.
- Kessler
- Khatun Hafiza
- Kidwai Tariq
- Kiefer Christie
- Kim Elaine H
- Kim Elaine H
- Kim Han G
- Kim Kwang Chung
- Kim Kyung Suh
- Kim Vivian C
- King Haitung
- Kitagawa Muriel
- Kittelson David J
- Klee Linnea Back
- Kleis Gerald W
- Kochiyama Yuri
- Kodani Jun
- Kodani Jun
- Kodani Jun
- Kotani Roland
- Krauss Bob
- Krener PG.
- Krich John
- Kuwano Doris
- Kwong J.
- Kwong Peter
- Labov Teresa
- LaBrack B.
- Lacaba Jose E
- Lai Him Mark
- Lai Violet L
- Lam Frankie
- Lam Lawrence
- Langberg Mark
- Lau
- Lazar Ineke M
- Lazar Thomas Frank
- Lee Chung Wen
- Lee Marjorie
- Leong F.T.L.
- Lesser Jeff H
- Li Xiao Lin
- Lieban Ruth
- Lim Derrick E
- Lim Paulino
- Lin Chien
- Lin E.H.B
- Lin Keh-Ming
- Lin Minoru Masuda
- Lin Patricia
- Lind Ian Y
- Ling Amy
- Ling Amy
- Ling Susie Hsiuhan
- Linnekin Jocelyn
- Liu
- Liu Zongren
- Liu Zongren
- Loenui Poka
- Loflin Marvin D
- Lorenzo May K
- Louie Emma Woo
- Louie Kem Betty
- Lukes
- Lum Russell H.Y.
- Lum Wing Tek
- Lumbera Bienvenido
- Lydon Sandy
- Lyman Stanford M
- Mahler R.
- Maniwatana Manu
- Mar Don
- Marks J.S.
- Martin Julia H
- Masumoto D. Mas.
- Masumoto D. Mas.
- Matnialrfor Indochinwc Shrdcntr
- Matsumoto Valerie
- Mayata Isabelle Yoshiko
- McCunn Ruthanne Lum
- McGlynn Katherine Ann
- McGowan
- Medina Belen T.G.
- Meeks Larry G
- Meredith William H
- Min Pyong Gap
- Minnesota State Commission on the Economic Status of Women.
- Moo Kini Esther T
- Morales Rodney
- Morantte P.C.
- Morgan Maria C
- Moriyama
- Moser R.J.
- Mukherjee Bharati
- Muller Thomas
- Naidoo Josephine C
- Nakano
- Nakayama Gordon G
- Nakayama Takeshi
- Nash Alice
- Nash Philip Tajitsu
- Nedbalek Lani
- Neidert Lisa J
- Netzorg Morton J
- New York State Education Department
- Nguyen San D
- Nicassio Perry M
- Nicassio Perry M
- Nordyke Eleanor C
- Norman Bob
- Notoji Masako
- Novotny Adrian S
- Oakley Linda Denise
- Obeid Raquf Taufic
- Odo Franklin S
- Oishi Gene
- Okamura B. Taeko.
- Okamura Jonathan Y
- Okamura Renee
- Okutsu Jim
- Okuyama Ikuko
- Omatsu Maryka
- Ong Paul M
- Orbach Michael K
- Padilla Amado M
- Padilla Raymond V
- Paganetti J.
- Pak Ping
- Pak Ty.
- Palinkas Lawrence
- Park Chong K
- Pecora Peter J
- Perez Gerald S.A.
- Perlrnan Robyn
- Peter
- Peters Heather
- Peterson Barbara Bennett
- Ph D.
- Pido Antonio J.A.
- Pillors Brenda Elaine
- Pliner Judith E
- Pratt Richard
- Ralston Caroline
- Rayson Ann
- Reder
- RedressforJapanese Canudians
- Reed Karen Lea
- Refqees
- Refugee Resettlement
- Reid Salu H
- Reilly Kenneth A
- Reischauer Haru Matsukata
- ResourceManual
- Riach YoungShik
- Richman D.
- Ridge Martin
- Robinson Leroy
- Rockett Ian R.H.
- Rogge J.R.
- Rose I.
- Ruiz Pedro
- Ryan Christine E
- Sage William W
- Saiki Patsy Sumi
- Saito Jiro
- Samuel TJ.
- San Juan E.
- Sandhu Teresa
- Santos Bienvenido N
- Saran Parmatma
- Sawada Noriko
- Saxton Alexander
- Scherer Marge
- Serita Toko
- Seto
- Shin E.H.
- Shook Victoria
- Sledge Linda Ching
- So Alvin Y
- Sobloff Burton
- Solomon I.D.
- Son Jin-Ok
- Song Moon-Ik
- Spero Abby
- States Mark
- Stauffer Bob H
- Stephan
- Stepien Edward K
- Stern P.N.
- Stern P.N.
- Stoloff David L
- Strand Paul J
- Sue Stanley
- Sue Stanley
- Sue Stanley
- Sung Betty Lee
- Takaki Ronald
- Takamura Jeanette C
- Takata Top
- Takemoto Karen Reiko
- Talrahashi Ferris
- Tanaka Donald
- Tanji Charlotte M
- Tanzer A.
- Tashima Eugene
- Tashima Nathaniel
- Taubin L.
- Taylor Sandra C
- Tchen John
- The Casefor Redress
- Thornton Michael Charles
- Tien Juliet L
- Tobin Joseph J
- Trask Haunani-Kay
- Trask Haunani-Kay
- Trotter Charlotte M.E
- Tsang Sau-Lim
- Tsui G. L.
- Tsukashima Ronald Tadao
- Turner Joan Alyne
- Ty-Casper Linda
- Tyreem Andrea
- Ueno Harry
- Underwood Robert A
- University of Hawaiiat Manoa
- University of Hawaiiat Manoa
- University of Hawaiiat Manoa
- Velez Gonzalo Alunan
- Viviano Frank
- Vohra-Sahu I
- Wagner Sandra E
- Wang Cynthia
- Wang Josephine
- Warheit George
- WataMbe Sylvia
- Wernick Allan
- Westwood Marvin J
- White W. Thomas.
- Wichman Frederick B
- Winchie Diana B
- Wisniewski Richard A
- Wlfsfeld Lynn
- Wlfsfeld Lynn
- Wong Eugene E
- Wong Morrison G
- Wong Samuel
- Woo Deborah
- Wooden Wayne S. J.H.
- Woodrum Eric
- Woolbright Louie Albert
- Yamamoto Hisaye
- Yamamoto Hisaye
- Yamane Kazuyo
- Yamasaki Emily Woo
- Yamashita Kanshi Stanley
- Yamazaki Tomoko
- Yanagisako SylviaJunko
- Yang Eun Si
- Yano Christine Reiko
- Yao Esther Lee
- Ye Ah Chong
- Yiu-Cheong So Alvin
- Yorita Peggy H
- Yost Monica Elizabeth
- Young
- Yu Lucy C
- Yum June Ock
- Yun
- Zia Helen Y
- Zinn Maxine Baca
- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study