Assemblages of solar electricity: enacting power, time and weather at home in the United Kingdom and Sri Lanka

This thesis explores what happens to the social enquiry of the powers of energy, if energy technologies and electricity are taken seriously as actants. It questions how photovoltaic solar panels and solar electricity act in everyday lives in domestic homes and how a more material enquiry of them can help shed light on the ways in which photovoltaic technology is made to matter in different places. It proposes to contribute to the social enquiry of energy by providing an example of how the power of electricity can be investigated and analyzed as a contingent achievement of particular assemblages rather than a neutral resource and affordance. Photovoltaic solar panels are enrolled in global discourses of environmental governance and sustainable development, and are employed not merely to generate electricity but also to have particular social powers: they generate electricity in different quantities and for different socio-political purposes in different places. As solar photovoltaic technology has gained momentum as a renewable energy technology that can be scaled and adjusted to fit different local and global matters of concern, it has also increasingly become part of different domestic homes, where it provides small portions of power for individual householders to use. This thesis considers two empirical settings where micro-generation solar is at work: in efforts to provide electricity to rural households in Sri Lanka and in efforts to reduce carbon emissions from households in the United Kingdom. The thesis argues that a tendency to focus on diffusion and social acceptance of solar in both policy and research has left gaps in our understanding of how solar works as a material force in everyday life after installation. The thesis engages with theories of assemblage and material agency and argues that the sustainability or green-ness of domestic solar power should not be considered an attribute of the technology, but rather seen as the achievement of a particular socio-material assemblage. It offers insights into how domestic solar is assembled and illustrates how solar electricity acts not as a neutral resource, which is handled and interpreted by human beings but rather as a spatially and temporally diverse force with properties and propensities, which encourage particular orderings of meaning and matter

Sociomaterial solar waste: afterlives and lives after of small solar

The problem of solar waste from off-grid technologies is attracting increasing attention. This chapter argues that solar waste represents multiple matters of concern; it is a problem of pollution, resource, and social ruin all together. It suggests that while an energy justice framework is well suited to identify issues of distributional, procedural, and recognition justice in relation to solar waste-what we refer to as "afterlives"-there is a need to engage with postcolonial theories of ethics in order to better grapple with different kinds of social ruins solar waste may represent-what we refer to as 'lives after'.</p

In Search of Complementarity: Insights from an Exercise in Quantifying Qualitative Energy Futures

In this study, we considered a bridging strategy between qualitative and quantitative research with the aim of achieving complementarity. A pilot case study using the Sheffield Elicitation Framework “SHELF” to estimate appropriate inputs for a quantitative energy systems model (based on a qualitative energy future scenario) was used to gain insights. Of novelty are the ethnographic insights of an example translation procedure as well as the methodological approach of the translation procedure itself. This paper reports the findings from this exercise concerning the practicalities of applying such a technique and the observations from the expert elicitation process itself. Based on this pilot, we make two recommendations. The first is the importance of devising a strategy in projects, and research programmes, where bridging between qualitative and quantitative research activities would be most effective. The second is that observations of discussions during the expert elicitation process provide value in the provenance of the estimates for quantitative modelling purposes and provide considerations for further development of qualitative future scenario

Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference

The Breast Cancer UK—Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour‐related breast‐cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupting chemicals (EDCs) Bisphenol A, per‐ and polyfluorinated alkyl substances as well as aluminium. However, laboratory studies have shown that multiple EDCs, can work together to exhibit effects, even when combined at levels that alone are ineffective. The TEXB‐α/β assay measures total estrogenic load, and studies have provided evidence of a link between multiple‐chemical exposures and breast cancer. However, prospective studies using TEXB‐α/β are needed to establish a causative link. There is also a need to assess real‐life exposure to environmental‐chemical mixtures during pregnancy, and their potential involvement in programming adverse foetal health outcomes in later life. Higher rates of breast cancer have occurred alongside increases in potentially‐modifiable risk factors such as obesity. Increasing body‐mass index is associated with increased risk of developing postmenopausal breast cancer, but with decreased risk of premenopausal breast cancer. In contrast, lower rates of breast cancer in Asian compared to Western populations have been linked to soya/isoflavone consumption. Risk is decreased by breastfeeding, which is in addition to the decrease in risk observed for each birth and a young first‐birth. Risk is lower in those with higher levels of self‐reported physical activity. Current evidence suggests breast‐cancer survivors should also avoid weight gain, be physically active, and eat a healthy diet for overall health. A broad scientific perspective on breast cancer risk requires focus on both environmental exposure to chemicals and health behaviour‐related risk. Research into chemical exposure needs to focus on chemical mixtures and prospective epidemiological studies in order to test the effects on breast cancer risk. Behaviour‐related research needs to focus on implementation as well as deeper understanding of the mechanisms of cancer prevention

Mapping the UK research & innovation landscape: Energy & development

The UK is already a major player in terms of research and innovation into low carbon transitions within the countries of the developing world. However, there are significant opportunities for the UK to enhance its presence within these markets whilst also making a major contribution to meeting international development targets and climate commitments. At the core of the research analysed in the report is that it reflects disparate, research initiatives funded with different research/innovation targets in mind; much latent strength in UK research for low carbon energy for development therefore is implicit in linkage possibilities enhancing systemic effectiveness, particularly by cross-fertilizing innovations taking place in the private sector. Gaps and weaknesses are reflected as much in the lack of collaborative initiatives and ‘siloization’ as in the absence of actual research/funding. The Low Carbon Energy for Development Network (LCEDN) is currently taking the initiative in one aspect of this through the provision of a programme of capacity building and partnership activities to support the development of DfID’s Transforming Energy Access research initiative. What is required of UK energy for development research for the purposes of building a functional system, however, is that the discrete areas of research outlined in this report be re-assembled as coherent, overall research narratives addressing the apparent contradiction of increasing energy access whilst transitioning to the low-carbon economy. Part of this work involves identifying the state and dynamics of UK research capacity in this sector, facilitating greater integration between research funders active in this area, evaluating gaps and key research needs and mapping potential future directions for research interventions and collaborations that build on, and develop, existing UK research capacity. It is expected that this will lead to a range of UK-led energy innovations developed, tested and scaled across developing countries by 2020. The much-needed harmonization of energy access and low carbon transition as a UK research theme however has ultimately to be created out of rethinking research fields from a combination of existing research, plus demand known to be ‘out there’ but which has yet to enter the field of vision of research-funders. This report presents the first part of this work with an overview of current UK research and innovation capacity in a widely defined ‘Energy and International Development’ research area. It identifies key institutions and research centres, thematic areas of excellence, research funding trends over the last decade, emerging research themes plus an overview of grant funding for innovation on the ground. A number of key areas/questions for potential further development of UK research and innovation capacity have been identified and are up for discussion and consultation. The work has been undertaken by LCEDN in partnership with the Knowledge Transfer Network, Energy 4 Impact and IOD PARC

Organism-sediment interactions govern post-hypoxia recovery of ecosystem functioning

Hypoxia represents one of the major causes of biodiversity and ecosystem functioning loss for coastal waters. Since eutrophication-induced hypoxic events are becoming increasingly frequent and intense, understanding the response of ecosystems to hypoxia is of primary importance to understand and predict the stability of ecosystem functioning. Such ecological stability may greatly depend on the recovery patterns of communities and the return time of the system properties associated to these patterns. Here, we have examined how the reassembly of a benthic community contributed to the recovery of ecosystem functioning following experimentally-induced hypoxia in a tidal flat. We demonstrate that organism-sediment interactions that depend on organism size and relate to mobility traits and sediment reworking capacities are generally more important than recovering species richness to set the return time of the measured sediment processes and properties. Specifically, increasing macrofauna bioturbation potential during community reassembly significantly contributed to the recovery of sediment processes and properties such as denitrification, bedload sediment transport, primary production and deep pore water ammonium concentration. Such bioturbation potential was due to the replacement of the small-sized organisms that recolonised at early stages by large-sized bioturbating organisms, which had a disproportionately stronger influence on sediment. This study suggests that the complete recovery of organism-sediment interactions is a necessary condition for ecosystem functioning recovery, and that such process requires long periods after disturbance due to the slow growth of juveniles into adult stages involved in these interactions. Consequently, repeated episodes of disturbance at intervals smaller than the time needed for the system to fully recover organism-sediment interactions may greatly impair the resilience of ecosystem functioning.

Assessment of the relative risk of water quality to ecosystems of the Great Barrier Reef. A report to the Department of the Environment and Heritage Protection, Queensland Government, Brisbane - Report 13/28

A risk assessment method was developed and applied to the Great Barrier Reef (GBR) to provide robust and scientifically defensible information for policy makers and catchment managers on the key land-based pollutants of greatest risk to the health of the two main GBR ecosystems (coral reefs and seagrass beds). This information was used to inform management prioritisation for Reef Rescue 2 and Reef Plan 3. The risk assessment method needed to take account of the fact that catchment-associated risk will vary with distance from the river mouth, with coastal habitats nearest to river mouths most impacted by poor marine water quality. The main water quality pollutants of concern for the GBR are enhanced levels of suspended sediments, excess nutrients and pesticides added to the GBR lagoon from the adjacent catchments. Until recently, there has been insufficient knowledge about the relative exposure to and effects of these pollutants to guide effective prioritisation of the management of their sources

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

Alternative splicing can produce multiple protein products with variable domain composition from a single gene. The mouse Tcf7l2 gene is subject to alternative splicing. It encodes TCF4, a member of the T-cell factor (TCF) family of DNA-binding proteins and a nuclear interaction partner of β-catenin which performs essential functions in Wnt growth factor signalling. Multiple TCF4 isoforms, potentially exhibiting cell-type-specific distribution and differing in gene regulatory properties, could strongly influence tissue-specific Wnt responses. Therefore, we have examined mouse Tcf7l2 splice variants in neonatal tissues, embryonic stem cells and neural progenitors. By polymerase chain reaction amplification, cloning and sequencing, we identify a large number of alternatively spliced transcripts and report a highly flexible combinatorial repertoire of alternative exons. Many, but not all of the variants exhibit a broad tissue distribution. Moreover, two functionally equivalent versions of the C-clamp, thought to represent an auxiliary DNA-binding domain, were identified. Depending upon promoter context and precise domain composition, TCF4 isoforms exhibit strikingly different transactivation potentials at natural Wnt/β-catenin target promoters. However, differences in C-clamp-mediated DNA binding can only partially explain functional differences among TCF4 variants. Still, the cell-type-specific complement of TCF4 isoforms is likely to be a major determinant for the context-dependent transcriptional output of Wnt/β-catenin signalling

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer

Purpose:; Resistance to platinum-based chemotherapy or PARP inhibition in germline; BRCA1; or; BRCA2; mutation carriers may occur through somatic reversion mutations or intragenic deletions that restore BRCA1 or BRCA2 function. We assessed whether; BRCA1/2; reversion mutations could be identified in circulating cell-free DNA (cfDNA) of patients with ovarian or breast cancer previously treated with platinum and/or PARP inhibitors.; Experimental Design:; cfDNA from 24 prospectively accrued patients with germline; BRCA1; or; BRCA2; mutations, including 19 patients with platinum-resistant/refractory ovarian cancer and five patients with platinum and/or PARP inhibitor pretreated metastatic breast cancer, was subjected to massively parallel sequencing targeting all exons of 141 genes and all exons and introns of; BRCA1; and; BRCA2; Functional studies were performed to assess the impact of the putative; BRCA1/2; reversion mutations on BRCA1/2 function.; Results:; Diverse and often polyclonal putative; BRCA1; or; BRCA2; reversion mutations were identified in cfDNA from four patients with ovarian cancer (21%) and from two patients with breast cancer (40%).; BRCA2; reversion mutations were detected in cfDNA prior to PARP inhibitor treatment in a patient with breast cancer who did not respond to treatment and were enriched in plasma samples after PARP inhibitor therapy. Foci formation and immunoprecipitation assays suggest that a subset of the putative reversion mutations restored BRCA1/2 function.; Conclusions:; Putative; BRCA1/2; reversion mutations can be detected by cfDNA sequencing analysis in patients with ovarian and breast cancer. Our findings warrant further investigation of cfDNA sequencing to identify putative; BRCA1/2; reversion mutations and to aid the selection of patients for PARP inhibition therapy.; Clin Cancer Res; 23(21); 6708-20. ©2017 AACR;