The accurate staging of ovarian cancer using 3T magnetic resonance imaging - a realistic option

Objectives: The aim of the study was to determine whether staging primary ovarian cancer using 3.0 Tesla (3T) magnetic resonance imaging (MRI) is comparable to surgical staging of the disease. Design: A retrospective study consisting of a search of the pathology database to identify women with ovarian pathology from May 2004 to January 2007. Setting: All women treated for suspected ovarian cancer in our cancer centre region. Sample: All women suspected of ovarian pathology who underwent 3T MRI prior to primary surgical intervention between May 2004 and January 2007. Methods: All women found to have ovarian pathology, both benign and malignant, were then cross checked with the magnetic resonance (MR) database to identify those who had undergone 3T MRI prior to surgery. The resulting group of women underwent comparison of the MR, surgical and histopathological findings for each individual including diagnosis of benign or malignant disease and International Federation of Gynecology and Obstetrics (FIGO) staging where appropriate. Main outcome measures: Comparisons were made between the staging accuracy of 3T MRI and surgical staging compared with histopathological findings and FIGO stage using weighted kappa. Sensitivity, specificity and accuracy were calculated for diagnosing malignant ovarian disease with 3T MRI. Results: A total of 191 women identified as having ovarian pathology underwent imaging with 3T MR and primary surgical intervention. In 19 of these women, the ovarian disease was an incidental finding. The group for which staging methods were compared consisted of 77 women of primary ovarian malignancy (20 of whom had borderline tumours). 3T MRI was able to detect ovarian malignancy with a sensitivity of 92% and a specificity of 76%. The overall accuracy in detecting malignancy with 3T MRI was 84%, with a positive predictive value of 80% and negative predictive value of 90%. Statistical analysis of the two methods of staging using weighted kappa, gave a K value of 0.926 (SE ±0.121) for surgical staging and 0.866 (SE ±0.119) for MR staging. A further analysis of the staging data for ovarian cancers alone, excluding borderline tumours resulted in a K value of 0.931 (SE ±0.136) for histopathological staging versus MR staging and 0.958 (±0.140) for histopathological stage versus surgical staging. Conclusion: Our study has shown that MRI can achieve staging of ovarian cancer comparable with the accuracy seen with surgical staging. No previous studies comparing different modalities have used the higher field strength 3T MRI. In addition, all other studies comparing radiological assessment of ovarian cancer have grouped the stages into I, II, III and IV rather than the more clinically appropriate a, b and c subgroups. © 2008 The Authors

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis

This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press.Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world. Historically, susceptibility to IA has been associated with prolonged neutropenia; however, IA has now become a major problem in patients on calcineurin inhibitors and allogenic hematopoetic stem cell transplant patients following engraftment. These observations suggest complex cellular mechanisms govern immunity to IA. Methods - To characterize the key early events that govern outcome from infection with Aspergillus fumigatus we performed a comparative immunochip microarray analysis of the pulmonary transcriptional response to IA between cyclophosphamide-treated mice and immunocompetent mice at 24 h after infection. Results - We demonstrate that death due to infection is associated with a failure to generate an incremental interferon-γ response, increased levels of interleukin-5 and interleukin-17a transcript, coordinated expression of a network of tumor necrosis factor–α-related genes, and increased levels of tumor necrosis factor–α. In contrast, clearance of infection is associated with increased expression of a number genes encoding proteins involved in innate pathogen clearance, as well as apoptosis and control of inflammation. Conclusion - This first organ-level immune response transcriptional analysis for IA has enabled us to gain new insights into the mechanisms that govern fungal immunity in the lung.The BBSRC, CGD Research Trust, and the MRC

Combining Sources of Description for Approximating Music Similarity Ratings

In this paper, we compare the effectiveness of basic acoustic features and genre annotations when adapting a music similarity model to user ratings. We use the Metric Learning to Rank algorithm to learn a Mahalanobis metric from comparative similarity ratings in in the MagnaTagATune database. Using common formats for feature data, our approach can easily be transferred to other existing databases. Our results show that genre data allow more effective learning of a metric than simple audio features, but a combination of both feature sets clearly outperforms either individual set

Optical properties of a light-emitting polymer directly patterned by soft lithography

Copyright © 2002 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters 81 (2002) and may be found at http://link.aip.org/link/?APPLAB/81/1955/1We present the optical properties of a directly patterned light-emitting polymer. The patterned poly(2-methoxy-5-(3',7'-dimethyloctyloxy)-paraphenylenevinylene film is fabricated using hot embossing lithography. The effect of the embossed microstructure on the light emitted from the polymer is examined by measuring the angle-dependent photoluminescence and its photonic band structure. The imposed grating modifies the emitted light by Bragg scattering into free space light that would otherwise be trapped as waveguide modes. This simple patterning technique may find application in improving the performance of light-emitting polymer devices

Phase diagrams of correlated electrons: systematic corrections to the mean field theory

Perturbative corrections to the mean field theory for particle-hole instabilities of interacting electron systems are computed within a scheme which is equivalent to the recently developed variational approach to the Kohn-Luttinger superconductivity. This enables an unbiased comparison of particle-particle and particle-hole instabilities within the same approximation scheme. A spin-rotation invariant formulation for the particle-hole instabilities in the triplet channel is developed. The method is applied to the phase diagram of the t-t' Hubbard model on the square lattice. At the Van Hove density, antiferromagnetic and d-wave Pomeranchuk phases are found to be stable close to half filling. However, the latter phase is confined to an extremely narrow interval of densities and away from the singular filling, d-wave superconducting instability dominates

Photonic band structure and emission characteristics of a metal-backed polymeric distributed feedback laser

Copyright © 2002 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters 81 (2002) and may be found at http://link.aip.org/link/?APPLAB/81/954/1Optical losses associated with the metallic contacts necessary for charge injection are an obstacle to the development of an electrically pumped polymer laser. We show that it may be possible to overcome these losses by demonstrating the operation of a distributed-feedback polymer laser fabricated upon a silver substrate. The device lasing threshold was ~150 times greater than that of an otherwise similar metal-free device, though similar to early polymer lasers. The device emission characteristics correlated well with the measured photonic band structure, allowing an explanation of the effect of the microstructure on device operation

Operating characteristics of a semiconducting polymer laser pumped by a microchip laser

Copyright © 2003 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters 82 (2003) and may be found at http://link.aip.org/link/?APPLAB/82/313/1We report the demonstration of a compact, all-solid-state polymer laser system featuring a microchip laser as the pump source. The laser was configured as a surface-emitting, two-dimensional distributed feedback laser, based on the conjugated polymer poly(2-methoxy-5-(2'-ethylhexyloxy)-1,4-phenylene vinylene). Pulsed, band-edge lasing was observed at 636 nm above a threshold pump energy of 4 nJ. The laser exhibited an energy slope efficiency of 6.8%, with a maximum output energy of 1.12 nJ at a pump energy of 20.4 nJ. The output beam had an azimuthally polarized annular profile with a beam quality factor (M2) of 2.2, close to the theoretical value of the lowest-order Laguerre–Gaussian and Bessel–Gaussian annular modes. We explain the origin of the azimuthal polarization as due to a coherent combination of the resonant fields supported by the two gratings

Legumes are different:Leaf nitrogen, photosynthesis, and water use efficiency

Using robust, pairwise comparisons and a global dataset, we show that nitrogen concentration per unit leaf mass for nitrogen-fixing plants (N(2)FP; mainly legumes plus some actinorhizal species) in nonagricultural ecosystems is universally greater (43–100%) than that for other plants (OP). This difference is maintained across Koppen climate zones and growth forms and strongest in the wet tropics and within deciduous angiosperms. N(2)FP mostly show a similar advantage over OP in nitrogen per leaf area (N(area)), even in arid climates, despite diazotrophy being sensitive to drought. We also show that, for most N(2)FP, carbon fixation by photosynthesis (A(sat)) and stomatal conductance (g(s)) are not related to N(area)—in distinct challenge to current theories that place the leaf nitrogen–A(sat) relationship at the center of explanations of plant fitness and competitive ability. Among N(2)FP, only forbs displayed an N(area)–g(s) relationship similar to that for OP, whereas intrinsic water use efficiency (WUE(i); A(sat)/g(s)) was positively related to N(area) for woody N(2)FP. Enhanced foliar nitrogen (relative to OP) contributes strongly to other evolutionarily advantageous attributes of legumes, such as seed nitrogen and herbivore defense. These alternate explanations of clear differences in leaf N between N(2)FP and OP have significant implications (e.g., for global models of carbon fluxes based on relationships between leaf N and A(sat)). Combined, greater WUE and leaf nitrogen—in a variety of forms—enhance fitness and survival of genomes of N(2)FP, particularly in arid and semiarid climates

Micromegas TPC studies at high magnetic fields using the charge dispersion signal

The International Linear Collider (ILC) Time Projection Chamber (TPC) transverse space-point resolution goal is 100 microns for all tracks including stiff 90 degree tracks with the full 2 meter drift. A Micro Pattern Gas Detector (MPGD) readout TPC can achieve the target resolution with existing techniques using 1 mm or narrower pads at the expense of increased detector cost and complexity. The new MPGD readout technique of charge dispersion can achieve good resolution without resorting to narrow pads. This has been demonstrated previously for 2 mm x 6 mm pads with GEMs and Micromegas in cosmic ray tests and in a KEK beam test in a 1 Tesla magnet. We have recently tested a Micromegas-TPC using the charge dispersion readout concept in a high field super-conducting magnet at DESY. The measured Micromegas gain was found to be constant within 0.5% for magnetic fields up to 5 Tesla. With the strong suppression of transverse diffusion at high magnetic fields, we measure a flat 50 micron resolution at 5 Tesla over the full 15 cm drift length of our prototype TPC.Comment: 7 pages, 3 figure