Electrochemical investigation and DNA-binding studies of pefloxacin-metal(II/III) complexes

WOS: 000299470600010Complexes of pefloxacin (PEF), with Cu(II), Zn(II), Pt(II), Ru(III), and Fe(III) have been synthesized and characterized by spectroscopic techniques involving UV-Vis, IR, H-1-HMR, CHN elemental analysis, electrochemical, and thermal behaviors. The electrochemical properties of all complexes were investigated by cyclic voltammetry (CV) using a glassy carbon electrode. The biological activities of the complexes have been evaluated by examining their ability to bind to calf thymus DNA (CT-DNA) with UV spectroscopy and CV. UV studies of the interaction of the complexes with DNA show that these compounds can bind to CT-DNA and the binding constants have been calculated. The cyclic voltammograms of the complexes in the presence of CT-DNA show that the complexes can bind to CT-DNA by intercalative and electrostatic binding. The antimicrobial activities of these complexes have been evaluated against three Gram-positive and four Gram-negative bacteria. Antifungal activities against two different fungi have been evaluated and compared with pefloxacin as reference. Almost all complexes show excellent activity against all bacteria and fungi.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T020]; KSUKing Saud UniversityKahramanmaras Sutcu Imam University [2009/2-8]The authors thank TUBITAK (Project No: 109T020) and KSU (Project No: 2009/2-8) for financial support