Synthesis and antioxidant and antimicrobial evaluation of novel 4-substituted-1H-1,2,4-triazole derivatives

A series of 4-benzyl/phenyl-3-(1-methyl-1H-indole-2-yl)-1H-1,2,4-triazole-5(4H)-thione (4a,b) and 2-{4-[benzyl/phenyl-5-(substitutedbenzylthio)]-4H-1,2,4-triazole-3-yl}-1-methyl-1H-indole derivatives (5a-p) were synthesized and evaluated for their in vitro scavenging of DPPH and superoxide radical, and lipid peroxidation inhibition effects as well as their antimicrobial properties. DPPH radical scavenging capacity was found to be equipotent with BHT and found in compounds containing 1,2,4-triazole-5(4H) -thione moiety (4a,b). With regard to antimicrobial properties, compound 5k showed slight antimicrobial activity against all the test microorganisms

Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles

In this study, we report the design, synthesis and antioxidant activity of a series of substituted 2-(4-aminophenyl)-1H-indoles and 2-(methoxyphenyl)-1H-indoles. The new compounds are structurally related to the known indole-based antioxidant lead compound melatonin (MLT), and the antitumour 2-(4-aminophenyl)benzothiazole and 2-(3,4-dimethoxyphenyl)benzothiazole series. Efficient access to the target 2-phenylindoles was achieved via Fischer indole synthesis between substituted phenylhydrazines and acetophenones. 2-(4-Aminophenyl)indoles (such as the 6-fluoro analogue 3b) in particular showed potent antioxidant activity in the DPPH and superoxide radical scavenging assays (80% and 81% inhibition at 1mM concentration of 3b, respectively), at a level comparable with the reference standard MLT (98% and 75% at 1 mM)

Chemical Composition and Antimicrobial Activity of the Essential Oil of Endemic Heracleum platytaenium Boiss. from Turkey

WOS: 000322840800006The compositions of the essential oil of Heracleum platytaenium Boiss. aerial parts, grown in Turkey were determined by GC-MS. Twenty-two compounds (95.24 %) were determined. the major compounds in the oil were found to be octyl acetate (85.53 %), octyl hexanoate (3.06 %), (Z)-4-octenyl acetate (1.60 %) and octyl octanoate (1.24 %). the antimicrobial activity of essential oil extracted from H. platytaenium against various yeast and bacteria species using the disc diffusion method was investigated during the present study. the extract exhibited strong antimicrobial activity against Candida glabrata with inhibition zones varying between 12-32 mm. in contrast, the growth of all the tested bacteria were not affected by the extract. in conclusion, this study confirms that H. platytaenium essential oil could be considered as a natural anticandidal source.Ondokuz Mayis University Research FundsOndokuz Mayis UniversityThis work was supported by Ondokuz Mayis University Research Funds

IMMUNOCYTOCHEMICAL EVALUATION OF GLUTATHIONE-S-TRANSFERASE P1 ENZYME IN PATIENTS WITH RHEUMATOID ARTHRITIS

WOS: 000464517600174

GLUTATHIONE-S-TRANSFERASE AND P53 EXPRESSIONS IN HUMAN MALIGNANT, BENIGN AND METASTASIS OVARIAN TUMOR TISSUES

WOS: 000464517600173

Evaluation of the Antioxidant Potency of Seseli L. Species (Apiaceae)

Objectives: In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from the aerial parts of Seseli L. species was investigated for the first time. Materials and Methods: Seseli species L. such as Seseli andronakii Woronow ex Schischk., S. campestre Besser, S. corymbosum Boiss. \& Heldr., S. gummiferum subsp. gummiferum Pall. ex Sm., S. hartvigii Parolly \& Nordt, S. libanotis (L.) W.Koch, S. petraeum M.Bieb., S. peucedanoides (M.Bieb.) Koso-Pol., S. resinosum Freyn \& Sint., and S. tortuosum L. growing in Turkey were collected and evaluated for their antioxidant capacity by using 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and lipid peroxidation (LPO) inhibition methods. Results: The highest activities as a scavenger of DPPH radicals were found in the AcOEt extracts of S. peucedanoides (M.Bieb.) Koso-Pol (IC50=0.49 mg/mL), and S. libanotis (IC50=0.75 mg/mL); alpha-tocopherol was used as a positive control. On the other hand, in the LPO assay, the highest activities were determined in AcOEt and MeOH extracts (at 5 mg/mL) of S. tortuosum and S. libanotis (84-94\%). Conclusion: This report gives important information about the antioxidant capacity of Seseli L. species. This research on antioxidant capacity proves that the use of some species used in Eastern Anatolia (in salads) is correct. With this screening study performed in Seseli L. species growing in Turkey, in the future, it is planned to isolate antioxidant compounds from the most active strains of Seseli L