Evoluţia principalilor parametrii fizico-chimici din vinul de fetească neagră în urma tratării vinului cu compuşi cu structură azaheterociclică

The present study describes the evolution of the main phisico- chemical parameters from Fetească neagră wine after treatment with azaheterocycles compounds. The physical and chemical analysis emphasizes the wine peculiarities. In our work were analyzed: free SO2 and total SO2, volatile acidity, total acidity, density, alcoholic concentration, remanent sugars, pH. For each parameter the study was performed according to the methods and regulations of the International Organization of Vine and Wine (OIV)

Pyridazinic Bioisosteres with Potential Applications in Medicinal Chemistry and Agriculture

Bioisosteres are substituents or groups (atoms, ions, or molecules) with similar chemical or physical properties, and which usually have similar biological properties. Pyridazine and its derivatives are invaluable scaffolds in medicinal chemistry, having a large variety of activities such as antibacterial, antifungal, antimalarial, anticancer, antituberculosis, antihypertensive, etc. Also, the pyridazine core is of high interest in agriculture, being used as a growth factor for plants, herbicides, etc. This study aims to review our previous contributions related to antimicrobials and the germination and seedling capabilities of some seeds and plants of some pyridazine classical and nonclassical bioisosteres. So, we present herein the synthesis (under conventional thermal heating and microwave irradiation) and spectral characterization of seven series of pyridazine bioisosteres, the in vitro antimicrobial activity (against different strains of Gram-positive and Gram-negative bacteria and fungi), and the biologic effect on wheat germination and seedling growth. Some pyridazine bioisosteres proved to have very good activity against pathogenic bacterial strains, with some spectacular results. Overall, nonclassical bioisosteres prove to have better antibacterial and antifungal activity compared with classical bioisosteres. The pyridazine bioisosteres may influence the wheat germination rate, seedling growth, height, and weight of the plantlets. Feasible explanations for this behaviour were furnished

Derivați de piridazină cu activitate antimicrobiană

Twenty nine pyridazine derivatives (3 salts and 25 pyrrolopyridazine cycloadducts) were prepared and tested in vitro as antimicrobial compounds. Some of them have proved to have a remarkable activity against different microorganisms (germs and fungi)

Evaluarea cipermetrinului din struguri și posibila remanență la vinuri

The use of insecticides in crops is needed to provide an increase of production at relatively low cost. Lately increased chemisationto crop led to problems in the food, but also directly with animal health or in directly to human consumption. In the present work we propose to study such a substance, namely cypermethrin, which is used widely by human society. The method used is sensitive (SBSE-GC-MS) with a limit of ppb-level for identification and quantification relatively wide interval. We try to eliminate the intermediate steps in order to reduceother influences. Results showed the presence of these substances in grapes, but in relatively low concentrations and lack of it to wine, below the quantification limit of 1 pp

Determinarea capacitătii antioxidante totale a unor vinuri roşii prin metode electrometrice şi spectrofotometrice

Phenolic compounds from various food matrices can be investigated with different analytical techniques such as spectrophotometric, cromatographic or electrochemic methods. Cupric Reducing Antioxidant Capacity method (CUPRAC) is a convenient assay for determining total antioxidant capacity in food substrates. In this work, electrochemical and spectrophotometrical approaches were used to estimate the total antioxidant capacity by means of an alternative of the CUPRAC assay, as the concentrations of the participating species ([Cu(Nc)2]2+ and [Cu(Nc)2]1+) can be evaluated by electrochemical and spectrophotometrical methods. The electrometric–CUPRAC methods have been applied to measure total antioxidant capacity of different local wines and validated against the spectrophotometric CUPRAC assay. The electrochemical methods proved to be easy, fast and with low detection limits. A good correlation for the total antioxidant capacity determined by CUPRAC spectrofotometric and electrometric method versus total phenol content (determined by Folin-Ciocalteu Method) was recorded, wich highlights that wines antioxidant activity results mainly from their phenolics content