Launching and Control of Graphene Plasmons by Nanoridge Structures

The unique properties of graphene plasmons show great potential for plasmonic nanodevice applications such as sensors and modulators. Graphene plasmon launching, propagation control, and ultimately launching with directional control are therefore crucial for the development of such devices. However, previous studies have used foreign objects or external influencing factors to attain directional plasmon launching on graphene, which introduce defects and add complexity to the system. This study introduces a theoretical framework for a graphene-only approach to direction-controlled plasmon launching. We use graphene nanoridges, a defect-free natural structure of graphene, as a plasmon launcher. Through proper arrangement of the nanoridges, unidirectional, bidirectional, and wavelength-sorted plasmon launching with normal illumination can be achieved

Launching and Control of Graphene Plasmons by Nanoridge Structures

The unique properties of graphene plasmons show great potential for plasmonic nanodevice applications such as sensors and modulators. Graphene plasmon launching, propagation control, and ultimately launching with directional control are therefore crucial for the development of such devices. However, previous studies have used foreign objects or external influencing factors to attain directional plasmon launching on graphene, which introduce defects and add complexity to the system. This study introduces a theoretical framework for a graphene-only approach to direction-controlled plasmon launching. We use graphene nanoridges, a defect-free natural structure of graphene, as a plasmon launcher. Through proper arrangement of the nanoridges, unidirectional, bidirectional, and wavelength-sorted plasmon launching with normal illumination can be achieved

Launching and Control of Graphene Plasmons by Nanoridge Structures

The unique properties of graphene plasmons show great potential for plasmonic nanodevice applications such as sensors and modulators. Graphene plasmon launching, propagation control, and ultimately launching with directional control are therefore crucial for the development of such devices. However, previous studies have used foreign objects or external influencing factors to attain directional plasmon launching on graphene, which introduce defects and add complexity to the system. This study introduces a theoretical framework for a graphene-only approach to direction-controlled plasmon launching. We use graphene nanoridges, a defect-free natural structure of graphene, as a plasmon launcher. Through proper arrangement of the nanoridges, unidirectional, bidirectional, and wavelength-sorted plasmon launching with normal illumination can be achieved

Systematic Protein Level Regulation via Degradation Machinery Induced by Genotoxic Drugs

In this study we monitored protein dynamics in response to cisplatin, 5-fluorouracil, and irinotecan with different concentrations and administration modes using “reverse-phase” protein arrays (RPPAs) in order to gain comprehensive insight into the protein dynamics induced by genotoxic drugs. Among 666 protein time-courses, 38% exhibited an increasing trend, 32% exhibited a steady decrease, and 30% fluctuated within 24 h after drug exposure. We analyzed almost 12,000 time-course pairs of protein levels based on the geometrical similarity by correlation distance (<i>dCor</i>). Twenty-two percent of the pairs showed <i>dCor</i> > 0.8, which indicates that each protein of the pair had similar dynamics. These trends were disrupted by a proteasome inhibitor, MG132, suggesting that the protein degradation system was activated in response to the drugs. Among the pairs with high <i>dCor</i>, the average <i>dCor</i> of pairs with apoptosis-related protein was significantly higher than those without, indicating that regulation of protein levels was induced by the drugs. These results suggest that the levels of numerous functionally distinct proteins may be regulated by common degradation machinery induced by genotoxic drugs

Depletion of RAD18 suppressed entry into the M phase from the G2 phase after IR exposure.

<p>(A) HT1080 cells transfected with si-ctrl or si-RAD18 were exposed to 1 or 2 Gy IR, and then lysed at the indicated time points, after irradiation. Samples were analyzed by western blotting with the indicated antibodies. (B) Cells were exposed to 1 Gy of IR, fixed with ethanol at the indicated time points after irradiation, and then immunostained with phospho-histone H3 and propidium iodide (PI). The percentage of G2/M phase cells was determined by flow cytometry. Each value represents the mean (+standard deviation) of the results from three independent experiments. (C) Cells were exposed to various doses of IR and then fixed with ethanol 60 min after irradiation. The fixed cells were immunostained with phosphor-histone H3 and PI. The percentage of G2/M phase cells was determined by flow cytometry. Each value represents the mean (+standard deviation) of the results from three independent experiments.</p

Depleting RAD18 suppressed the response to DNA damage induced by IR.

<p>HEK293 cells were transfected with si-ctrl or si-RAD18, irradiated with 2 or 4 Gy, and then lysed at the indicated time points after irradiation. Samples were analyzed by western blotting with the indicated antibodies.</p

RAD18-deficiency increased apoptosis in murine thymocytes <i>in vivo</i>.

<p><i>Rad18</i>^<i>+/+</i>, <i>Rad18</i>^<i>+/-</i>, and <i>Rad18</i>^-/- mice were irradiated with 1Gy IR. Thymocytes were isolated at the time points indicated after irradiation. Apoptotic cell distributions in thymocytes were detected by using PE Annexin V Apoptosis Detection kit I and analyzed using flow cytometry. Each value represents the mean (+standard deviation) of the results from the individual mice.</p

Activity concentration of ¹³⁴Cs, ¹³⁷Cs, ^110mAg and ^129mTe in cattle organs and peripheral blood.

a<p>Decay correction was made to the day major release of radionuclides, March 15, 2011.</p>b<p>SD: the standard deviation.</p>c<p>num: the number of the samples positive for the deposition of radionucleides.</p>d<p>ND: not detectable.</p>e<p>The Number of positive samples/the number of tested samples. All the samples were positive for ¹³⁴Cs and ¹³⁷Cs.</p

Distribution of Artificial Radionuclides in Abandoned Cattle in the Evacuation Zone of the Fukushima Daiichi Nuclear Power Plant

<div><p>The Fukushima Daiichi Nuclear Power Plant (FNPP) accident released large amounts of radioactive substances into the environment. In order to provide basic information for biokinetics of radionuclides and for dose assessment of internal exposure brought by the FNPP accident, we determined the activity concentration of radionuclides in the organs of 79 cattle within a 20-km radius around the FNPP. In all the specimens examined, deposition of Cesium-134 (¹³⁴Cs, half-life: 2.065 y) and ¹³⁷Cs (30.07 y) was observed. Furthermore, organ-specific deposition of radionuclides with relatively short half-lives was detected, such as silver-110m (^110mAg, 249.8 d) in the liver and tellurium-129m (^129mTe, 33.6 d) in the kidney. Regression analysis showed a linear correlation between the radiocesium activity concentration in whole peripheral blood (PB) and that in each organ. The resulting slopes were organ dependent with the maximum value of 21.3 being obtained for skeletal muscles (R² = 0.83, standard error (SE) = 0.76). Thus, the activity concentration of ¹³⁴ Cs and ¹³⁷Cs in an organ can be estimated from that in PB. The level of radioactive cesium in the organs of fetus and infants were 1.19-fold (R² = 0.62, SE = 0.12), and 1.51-fold (R² = 0.70, SE = 0.09) higher than that of the corresponding maternal organ, respectively. Furthermore, radiocesium activity concentration in organs was found to be dependent on the feeding conditions and the geographic location of the cattle. This study is the first to reveal the detailed systemic distribution of radionuclides in cattle attributed to the FNPP accident.</p> </div