Feature extraction method for clock drawing test

Recently, the number of elderly persons with dementia has been increasing. In the past, we proposed a dementia evaluation system using daily conversations and developed the system with a conversational robot. However, the current system is not ready for practical use because it can only evaluate time/geographical orientation and short-term memory, and some methods to evaluate other orientations and functions is required as well. In this paper, we discuss a new dementia evaluation system using not only daily conversations but also drawing tests. The authors employed a Clock Drawing Test (CDT) as a new dementia evaluation test and implemented it in a tablet device. This paper discusses a feature extraction and recognition method to distinguish normal cases from dementia cases. After evaluation experiments, the proposed method could recognize 87.6% of the clock drawing images

Extraction of Disease Area from Retinal Optical Coherence Tomography Images Using Three Dimensional Regional Statistics

AbstractWe propose a new extraction method of the macular disease area in the human retinal layer from OCT images using three dimensional regional statistics. In previous researches, we extracted disease area by using the mean and standard deviation of the two dimensional disease part pointed out by a clinical doctor. However, the previous method cannot extract disease area for some disease OCT images precisely. In this paper, we propose a new extraction method of the disease area using three dimensional regional statistics. We use a set of 128 images (3D-OCT image) consisted of 2 dimensional OCT retinal image about one retina of a patient. The regional mean and regional standard deviation of gray level are calculated in the three dimensional region of interest (ROI, 125 (=5 × 5 × 5) pixels) in the abnormal area pointed by a clinical doctor. These values are compared with every ROI in the abnormal area to extract the disease area, and the proposal system measures the volume of the disease area. We apply the proposed method to OCT images of 5 patients with retinal diseases. As a result, we can measure the volume of the abnormal area with 80.7% average accuracy

Dementia detection using weighted direction index histograms and SVM for clock drawing test

AbstractIncreasing the number of elderly persons who have dementia is one of the severe social problems. In Japan, the Ministry of Health, Labor and Welfare expects that the number of dementia patients will be around 5 million in 2025. It is also easily estimated that they require various living supports. Therefore, early detection and prevention of dementia are important. The authors have been developing a new system for quantitative and accurate evaluation of dementia. The basic concept of our system is evaluating a patient's dementia types and progression without awareness. To realize this, we are now developing the system using daily conversations, drawings, facial expressions and so on. In this paper, we focused on Clock Drawing Test (CDT) and proposed a dementia evaluation method for CDT. In the proposed method, Weighted Direction Index Histogram Method was used to extract features from given images, and Support Vector Machine (SVM) detected dementia cases from them. As a result of evaluation experiments, the proposed method could detect 97.1% of dementia cases correctly

A study on classification using machine learning for dementia evaluation

Recently, the number of dementia patients has been increasing due to the aging society. In Japan, a paper-based examination is the main-stream to measure the cognitive function of a subject, but these paper-based tests give much burden to not only patients but also evaluators like facility and medical staff. Therefore, it is necessary to develop a system that can automatically judge the degree of dementia progression, not to burden the doctor. Also, it is required to add play ability not to be a burden on the elderly. From this point of view, the authors developed a recreation game like a puzzle game. This system is easy to play for elderly people and is not a burden. Also, the question-answer is clear, so it is suitable for automatic judgment. We use the obtained features during recreation game to diagnose the degree of dementia progression. We committed the capability of machine learning techniques. Finally, we discussed that the collected features are sufficient to diagnose the degree of dementia progression

Prenatal diagnosis of severe mitochondrial diseases caused by nuclear gene defects: a study in Japan

Prenatal diagnoses of mitochondrial diseases caused by defects in nuclear DNA (nDNA) or mitochondrial DNA have been reported in several countries except for Japan. The present study aimed to clarify the status of prenatal genetic diagnosis of mitochondrial diseases caused by nDNA defects in Japan. A comprehensive genomic analysis was performed to diagnose more than 400 patients, of which, 13 families (16 cases) had requested prenatal diagnoses. Eight cases diagnosed with wild type homozygous or heterozygous variants same as either of the heterozygous parents continued the pregnancy and delivered healthy babies. Another eight cases were diagnosed with homozygous, compound heterozygous, or hemizygous variants same as the proband. Of these, seven families chose to terminate the pregnancy, while one decided to continue the pregnancy. Neonatal- or infantile-onset mitochondrial diseases show severe phenotypes and lead to lethality. Therefore, such diseases could be candidates for prenatal diagnosis with careful genetic counseling, and prenatal testing could be a viable option for families