Geographical and Orbital Information Based Mobility Management to Overcome Last-Hop Ambiguity over IP/LEO Satellite Networks

科研費報告書収録論文(課題番号:17500030/研究代表者:加藤寧/インターネットと高親和性を有する次世代低軌道衛星ネットワークに関する基盤研究

Network Controlled Handover for Improving TCP Performance in LEO Satellite Networks

科研費報告書収録論文(課題番号:18300017/研究代表者:根元義章/通信データ列特徴量の類似性に基づいた不正アクセス逆探知方式)68

Distributed Early Worm Detection Based on Payload Histograms

科研費報告書収録論文(課題番号:18300017/研究代表者:根元義章/通信データ列特徴量の類似性に基づいた不正アクセス逆探知方式)68

RelatiOnship between the impact of invasive largemouth bass and environmental conditions in ponds

detemine the relationship between the impact of introdllCed largemouth bass on native -fish fauna and the environmental conditions in ponds, we compared richness and diversityof fish species, environmental factors and the relationship betweenthem in ponds with and without bass. The stlldy was conducted at 49 Ponds in Oshu city in lwate prefecture, northeastern Japan･ For determiningthe impact of largemouth bass on fish fauna in ponds, Pearson's correlation wasused between the dominance of largemouth bass (%BASS), total number (S) and diversity index (H') of occurring fish species. Furthermore, multiple regression analysis was used to detemine the relationship between S or HT and environmental factors･ %BASS was negatively correlated with both S and H'. In ponds without bass, both S and H'were`related to maximum depth and S in ponds with bass was also related to maximum depth. However, I-r in ponds withbass was significantly influenced by the coverage of emergent plants and was more clearly explained compared to the relationship between S and maximum depth･ It suggested it is possible that emergent plants also provide refuge for prey fish, buffering the impact of largemouth bass･Article信州大学山地水環境教育研究センター研究報告 6: 133-141(2010)departmental bulletin pape

hzAnalyzer: detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets

The analysis of contiguous homozygosity (runs of homozygous loci) in human genotyping datasets is critical in the search for causal disease variants in monogenic disorders, studies of population history and the identification of targets of natural selection. Here, we report methods for extracting homozygous segments from high-density genotyping datasets, quantifying their local genomic structure, identifying outstanding regions within the genome and visualizing results for comparative analysis between population samples

Synergistic Pathogenic Effects of Combined Mouse Monoclonal Anti-Desmoglein 3 IgG Antibodies on Pemphigus Vulgaris Blister Formation

Pemphigus vulgaris (PV) is an autoimmune blistering disease caused by anti-desmoglein 3 (Dsg3) IgG antibodies. Previously, we generated an active mouse model for PV by adoptive transfer of splenocytes from immunized or naive Dsg3−/− mice. In this study, we isolated 10 anti-Dsg3 IgG mAbs (NAK-series) from PV model mice generated by transfer of naive Dsg3−/− splenocytes. We characterized their epitopes using domain-swapped and point-mutated Dsg1/Dsg3 molecules and examined their pathogenic activities in blister formation in three different assays. In a passive transfer model using neonatal mice, eight of 10 NAK mAbs showed pathogenic activity when injected together with half the minimum pathogenic dose of anti-Dsg1 IgG autoantibodies from pemphigus foliaceus (PF) patients. None of the mAbs could induce the PV phenotype when individual hybridoma clones were inoculated by peritoneal injection into adult Rag2−/− mice. NAK mAbs displayed a range of potency in an in vitro dissociation assay using primary cultured mouse keratinocytes. Interestingly, when multiple hybridoma clones recognizing different epitopes were inoculated in combination, recipient mice developed the PV phenotype. In vitro dissociation assays confirmed that combined NAK mAbs had synergistic pathogenic effects. These findings indicate that although an individual anti-Dsg3 IgG is not sufficient to cause blistering in adult mice, several together can induce the PV phenotype. These mAbs will provide a valuable tool to investigate the molecular mechanisms of blister formation, mimicking the effects of the polyclonal IgG antibodies found in patients

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

AbstractTespa1 has been recently reported to be a critical molecule in T-cell development, however, the precise molecular mechanisms of Tespa1 remain elusive. Here, we demonstrate that Tespa1 shows amino-acid sequence homology to KRAS-induced actin-interacting protein (KRAP), an inositol 1,4,5-trisphosphate receptor (IP3R) binding protein, and that Tespa1 physically associates with IP3R in T and B lymphocytes. Two-consecutive phenylalanine residues (Phe185/Phe186) in Tespa1, which are conserved between Tespa1 and KRAP, are indispensable for the association between Tespa1 and IP3R. These findings suggest that Tespa1 plays critical roles in the immune system through the regulation of the IP3R

Intrathoracic esophagogastric anastomosis using a linear stapler following minimally invasive esophagectomy in the prone position.

[Background] Minimally invasive esophagectomy (MIE) in the prone position typically includes thoracoscopic mediastinal dissection and laparoscopic gastric tube construction, followed by esophagogastric anastomosis in the neck. We introduced an intrathoracic esophagogastric anastomosis using linear staplers. [Technique] The lower mediastinal dissection and the gastric tube construction are done in the laparoscopic part of the operation. The esophagus is transected at the cranial level of the aortic arch after the completion of the upper mediastinal lymph node dissection in the prone position. The excess length of the gastric tube is sacrificed before making the anastomosis. Side-to-side esophagogastric anastomosis is performed using a 35-mm endoscopic linear stapler. The entry hole is closed with hand suturing using the posterior and the axillary port. [Results] Twenty-six patients with middle or lower esophageal tumor underwent MIE with an intrathoracic anastomosis. The mean thoracoscopic procedure time was 302 min. One patient had an anastomotic leakage, which was successfully managed with drainage. There has been no anastomotic stenosis. Pneumonia was observed in two patients. There was no mortality. [Conclusions] MIE with an intrathoracic linear-stapled anastomosis with the patient in the prone position is safe and feasible

Amyloidosis-induced Lower Gastrointestinal Bleeding in a Patient with Multiple Myeloma

We reported a case of gastrointestinal amyloidosis associated with multiple myeloma (MM), presenting with an unusual abdominal condition causing right upper abdominal pain and hematochezia. An abdominal examination revealed a huge tender mass below the right costal margin. A barium enema examination demonstrated a filling defect in the transverse colon and abdominal computed tomography disclosed an inhomogeneous mass. There was no evidence of thrombocytopenia or a coagulation factor deficiency. A surgical specimen showed deposit of amyloid substance in the colon. As this case illustrates, the absence of systemic symptoms of amyloidosis and nonspecific radiological findings in gastrointestinal amyloidosis may make the diagnosis difficult. Therefore, we recommend that a diagnosis of amyloidosis-induced bleeding of the colon should be considered in patients with multiple myeloma with obscure hemorrhaging