11 research outputs found
A rare case of internal jugular vein aneurysm with massive hemorrhage in neurofibromatosis type 1
AbstractNeurofibromatosis Type 1 (NF1) is a relatively common autosomal dominant disorder. Vascular involvement is a well-recognized manifestation of NF1, but venous aneurysm associated with NF1 is extremely rare. We present a case of an NF1 patient with a left internal jugular vein aneurysm with massive hemorrhage occurring during surgery. Due to the extreme fragility of both the aneurismal wall and the surrounding tissue, the patient developed severe intraoperative bleeding. Pathological examination confirmed aneurismal wall infiltration of the neurofibromatosis. Physicians should be aware that hemorrhagic complication in NF1 can occur and be fatal
Two cases of radiation-associated angiosarcoma of the breast
Abstract Background The incidence of radiation-associated angiosarcoma (RAA) of the breast has been increasing, and its prognosis is reportedly poor. It is important to remove tumor tissues completely to prevent recurrence. Case presentation We report two cases of patients with RAA of the breast. Both patients had a nodule in their remaining breast a few years after undergoing breast-conserving surgery and radiation therapy for breast cancer. The nodules were diagnosed as angiosarcoma by skin biopsy and open biopsy, respectively. To determine the extent of lesion spread, mapping biopsy was performed before surgery. Both patients underwent mastectomy, extensive skin resection, and split skin grafting. Pathological findings showed that their tumors could be completely resected. After surgery, chemotherapy was performed. Conclusion In our cases, no local or distant recurrence has been detected in either patient for over 4 years. We identified the range of tumor invasion by preoperative mapping biopsy and completely resected all tumor tissue
An autopsy case of epignathus (immature teratoma of the soft palate) with intracranial extension but without brain invasion: case report and literature review
Abstract Background Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an intracranial tumor. Case presentation A fetus at gestational week 27 was suspected of having an epignathus with intracranial tumor as shown by ultrasonographic and magnetic resonance imaging. The fetus was stillborn and an autopsy was performed. An epignathus measuring 12 × 6 × 6 cm and weighing 270 g protruded from the mouth, with its base on the soft palate. An intracranial tumor weighing 14 g was located at the middle intracranial fossa and connected to the epignathus through the right side of the sella turcica. The intracranial tumor was encapsulated, and there was no invasion into the brain. Histologically, both the epignathus and intracranial tumor were immature teratomas, with neural and pulmonary components that were especially immature as compared to those of the internal organs and brain tissues of the fetus. Conclusion There have been several reports of epignathus and intracranial tumors that did not communicate; therefore, careful evaluation is needed when a fetus is suspected of having an epignathus extending into an intracranial lesion. Our case supports the findings that an epignathus can directly expand into the cranium. Moreover, this is a rare case of an epignathus in which the intracranial lesion was encapsulated and did not invade the brain. These rare but important findings will provide additional, potential therapeutic strategies for gynecologists, neurosurgeons, and pathologists
Immunohistochemical expression of mucin antigens in gallbladder adenocarcinoma: MUC1-positive and MUC2-negative expression is associated with vessel invasion and shortened survival
Mucins play pivotal roles in influencing
cancer biology, for example affecting carcinoma
invasion, aggressiveness and/or metastatic potential. Our
aim is to investigate the significance of expression
profiles of two mucins in particular, MUC1 and MUC2,
their correlations with various clinicopathological
features, and prognosis in gallbladder adenocarcinoma
(GBAC). We performed immunohistochemistry from
patients with surgically resected GBAC, using
antibodies against mucin core proteins MUC1/DF3 and
MUC2/Ccp58 in 81 paraffin-embedded tumor samples.
MUC1 or MUC2 expression was considered to be high
when ≥20% or 10% of the GBAC cells showed positive
staining, respectively. High MUC1 expression was
revealed to have a significant relationship to the
presence of pathologically lymphatic and vascular
invasion, and regional lymph node metastasis. By
contrast, high MUC2 expression showed a significant
correlation with pathologically perineural invasion, T
stage ≥3, and post-operative recurrence. Moreover,
MUC1 showed significantly positive co-expression and
potentially complementary correlations with MUC2.
Multivariate analyses demonstrated that the high MUC1
expression group had significantly shorter diseasespecific survival times. However, the combination of
both high MUC1 and MUC2 expression did not predict
worse outcome in GBACs. Therefore, although each
mucin has a somewhat important role in the
pathogenesis of GBAC progression, MUC1 can
independently predict vessel invasion and poor
prognosis in patients with GBAC. The detection of
MUC1 might well offer a useful parameter for providing
clinical management and treatment against postsurgical
GBACs
Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase
In mucoepidermoid carcinoma (MEC), the
most common salivary gland carcinoma, there is a lack
of novel prognostic markers, but post-operative early
recurrence strongly affects the clinical course and a poor
outcome. It is critical to predict which MEC patients are
prone to develop recurrence/metastases. Mucins play
pivotal roles in influencing cancer biology, thus affecting
cell differentiation, adhesion, carcinoma invasion,
aggressiveness and/or metastatic potential. Our aim is to
elucidate the significance of expression profiles for
mucins, particularly MUC4 and MUC6, and their
correlations with various clinicopathological features
and recurrence in salivary gland MECs. We performed
immunohistochemical analyses on patients with
surgically resected primary MEC using antibodies
against mucin core proteins MUC4/8G7 and
MUC6/CLH5 in 73 paraffin-embedded samples.
Recurrence was noted in 15 of 73 (20.5%) patients.
MUC4 or MUC6 expression was considered to be
negative when <30% or 0% of the MEC cells showed
positive staining, respectively. MUC4- and/or MUC6-
negative expression respectively and variably showed a
significant relationship to pathological tumor high-grade,
the presence of lymphovascular invasion, lymph node
metastasis and/or tumor-related death. In addition,
MUC4 showed significantly negative co-expression with
MUC6. Kaplan-Meier analyses revealed that not only
single MUC4/6-negative expression but also the
combination of both predicted significantly shorter
disease-free and disease-specific survivals in MECs,
especially within the first two years postoperatively.
Therefore, each mucin plays a pivotal role in the
pathogenesis of MEC progression. The detection of
MUC4 and/or MUC6 might be a powerful parameter in
the clinical management of MECs in the early
postsurgical phase