57 research outputs found

    Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

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    Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk

    On the forcing of sea level in the Black Sea

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    Forcing mechanisms for sea level variability in the Black Sea are investigated in the context of an observed increase in the sea level of this basin by 2.5 mm/yr over the last 60 years. Temperature and salinity variations computed from the Mediterranean Data Archeology and Rescue (MEDAR) data set exhibit significant interdecadal variability. However, the corresponding steric height variation does not show a long-term increase and thus cannot account for the observed change in sea level. The impact of surface freshwater flux (P-E) changes is also investigated using two independent data sets. The first data set, which is based on measurements collected in the basin, can explain most of the sea level variability, with only 0.8 mm/yr remaining unexplained. The second data set, output from the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis, is unable to explain any of the observed trend. Potential contributions from changes in river runoff and surface pressure are quantified but found to be minor terms. By comparing the observed salinity changes with the sea level rise and the P-E variability in the first data set, we infer that the P-E variations are the primary cause for the observed sea level rise, while land movements are likely to partly contribute, too. The relationship of Black Sea temperature and salinity variability with corresponding variability in the connected Aegean Sea has also been explored. A significant correlation is found between the salinity of the upper water of the Aegean Sea and the layer between 50 and 300 m in the Black Sea, indicating that the latter layer is a product of the Mediterranean inflow
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