3 research outputs found

    APOE epsilon 4 allele affects presynaptic, but not postsynaptic cholinergic markers in Alzheimer's disease neocortex

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    The present study used electrical stimulation to distinguish the vesicular from the cytoplasmic component of transmitter release in human autopsy synaptosomes. We demonstrate that the present electrical stimulation paradigm can elicit successive release pulses from synaptosome preparation

    Therapeutic Potential of Multifunctional Tacrine Analogues

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