4 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
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- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
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- Andersen M
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- Andresen D
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- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Career Counseling Interventions for Video Game Players
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Cohort profile. the ESC-EORP chronic ischemic cardiovascular disease long-term (CICD LT) registry
- Author
- A Bileri
- A Chernova
- A Cinque
- A Ciobanu
- A Cosenza
- A Dimopoulos
- A Djordjevic-Dikic
- A G Cotoban
- A Gace
- A Galyavich
- A Garganeeva
- A Gaul
- A Gerlach
- A Gjana
- A Goda
- A Goda
- A Govorin
- A Gurghean
- A Hassan
- A Helal
- A I Suceveanu
- A Iancu
- A Ilic
- A Iliesiu
- A Kalnins
- A Kania
- A Kerimkulova
- A Kessler
- A Khosravi
- A Kletkina
- A Klug
- A Kochergina
- A Korczyńska
- A Kristo
- A Kuskaeva
- A L Pop-Moldovan
- A Lantzouraki
- A Ledyaeva
- A Libins
- A Linss
- A Lobanova
- A M A Elseaidy
- A M Iniesta Manjavacas
- A Magdy Moustafa
- A Martínez Cámara
- A Melia
- A Merezhanova
- A Nedbaykin
- A O Petris
- A Panov
- A Pecoraro
- A Perkan
- A Podbolotova
- A Przybylski
- A Rodrigues
- A Rosenthal
- A Rozumovitch
- A Rusali
- A Rusina
- A Sałacki
- A Semenova
- A Shutov
- A Skrobowski
- A Sołtowska
- A Stanczyk
- A Stojsic-Milosavljevic
- A Strelnieks
- A Tase
- A Ter-Margaryan
- A Tishukaj
- A Tokareva
- A Trikas
- A Veliz Martínez
- A Vienet-Legue
- A Wysokiński
- A Yousef
- A Ziakas
- A-E Elbakery
- A-M Vintilă
- Abdallah Mahdhaoui
- Adel El Etriby
- Alastair Gray
- Aldo P Maggioni
- Aldo P Maggioni
- Aleksandr Nedoshivin
- Ana Djordjevic Dikic
- Andrzej Budaj
- Anna-Sonia Petronio
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- Erkin Mirrakhimov
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- Iveta Mintale
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- Konstantinos Tsioufis
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- M A Cuoco
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- M Janion
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- Maggioni Aldo
- Maksym Sokolov
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- Parounak Zelveian
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- Tavazzi Luigi
- Uwe Zeymer
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- V Martinez Mateo
- V Mikitchuk
- V Ochean
- V Pylarinou
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- V Sujayeva
- Vakhtang Chumburidze
- Valgimigli Marco
- Vivien Klaudia Nagy
- Volha Sujayeva
- W Mohammed Mounir
- W Nafee
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- Z Galeeva
- Z Hakobyan
- Z Lazar
- Z Lominadze
- Z Tatarintseva
- Z Tsoumani
- Zoran Olivari
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
The European Society of cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease registry Long Term (CICD) aims to study the clinical profile, treatment modalities and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular risk are treated according to ESC guidelines on prevention or on stable coronary disease and to determine mid and long term outcomes and their determinants in this population
The Role of the Vocational Rehabilitation Consultant in Life Care Planning
- Author
- American Board
- Anastasi A.
- Anderson A.
- Barros-Bailey M.
- Barros-Bailey M.
- Bast S.
- Berens D. E.
- Blackwell T. L.
- Bolton B. F.
- Boyd D.
- Cohen M. D.
- Defense and Veterans Brain Injury Center
- Defense and Veterans Brain Injury Center
- Defense and Veterans Brain Injury Center
- Deming L.
- Deutsch P. M.
- Dillman E.
- Dillman E. G.
- Dowd L. R.
- Dunn P. L.
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- Field T. F.
- Gibson G. G.
- Ginzberg E.
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- Hamermesh D. S.
- Hamilton B.
- Havranek J.
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- Isom R.
- Johnson L. E.
- Jozaitis T.
- LifeStep
- Maki D. R.
- Maki D. R.
- Mare R. D.
- Marme M.
- Martin G.
- McCaigue I. S.
- McCroskey B. J.
- National Center for
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- Sarason S. B.
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- Weed R.
- Weed R. O.
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- Weed R. O.
- Weed R. O.
- Weed R. O.
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- Weed R. O.
- Weed R. O.
- Wehman P.
- West M.
- Woodside P.
- Zunker V. G.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study