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A homocoupling approach to the key dione of CyMe4-BTPhen β vital ligands for nuclear clean-up by the SANEX process
CyMe4-BTPhen and CyMe4-BTBP are the principal ligand systems used in Europe for the separation of actinides from lanthanides as a part of the SANEX process for nuclear recycling and reprocessing. We present a new approach to the synthesis of the CyMe4-fragment beginning from readily available hydroxypivalic acid. It features a cobalt-catalysed homocoupling of a neopentyl bromide to provide the key bis-ester precursor, thereby avoiding the requirement for technically challenging low temperature LDA-mediated aldol chemistries