3 research outputs found
CyberKnife for the management of Cushing’s disease: our institutional experience and review of literature
Introduction: Surgery is the primary treatment for Cushing’s disease(CD). In cases with no biochemical remission after surgical resection or when recurrence occurs after a period of remission stereotactic radiosurgery (SRS) is used as alternative/adjuvant treatment. The aim of this study is to demonstrate the effectiveness of SRS and FSRS(Fractionated stereotactic radiosurgery) for the treatment of CD in a long term follow up. Methods: This is a retrospective study in which 41 patient (36 females and 5 males) who underwent surgery for CD from 2009 to 2019 were included. Out of 41 cases, 34 cases had microadenomas while 7 had macroadenomas. These patients had recurrence or persistence of hypercortisolism post-operatively. After multidisciplinary evaluation, these patients were treated by CyberKnife (SRS & FSRS). Results: Remission rate in our study was 60.97% with a median follow up period of 79.03 months. The median time to biochemical remission was 14 months. Tumour growth control was achieved in 95.12%. Hypopituitarism of different axes was seen in 34.14% patients. Secondary hypothyroidism was the most common pituitary insufficiency (34%) followed by secondary hypogonadism in 17%. Conclusion: CyberKnife radiosurgery and hypofractionated radiosurgery can be used as an adjuvant treatment in patient with active disease and no biochemical remission after one or multiple surgical resections. Risk of radiation induced hypopituitarism and other complication is relatively low 34.14% and tumour growth control is significantly higher. © 2021 The Neurosurgical Foundation
Shock wave physics and detonation physics – a stimulus for the emergence of numerous new branches in science and engineering
In the period of the Cold War (1945−1991), Shock Wave Physics and Detonation Physics
(SWP&DP) – until the beginning of WWII mostly confined to gas dynamics, high-speed
aerodynamics, and military technology (such as aero- and terminal ballistics, armor
construction, chemical explosions, supersonic gun, and other firearms developments) –
quickly developed into a large interdisciplinary field by its own. This rapid expansion
was driven by an enormous financial support and two efficient feedbacks: the
Terminal Ballistic Cycle and the Research &
Development Cycle. Basic knowledge in SWP&DP, initially gained
in the Classic Period (from 1808) and further extended in the
Post-Classic Period (from the 1930s to present), is now increasingly
used also in other branches of Science and Engineering (S&E). However, also
independent S&E branches developed, based upon the fundamentals of SWP&DP,
many of those developments will be addressed (see Tab. 2). Thus, shock wave and detonation
phenomena are now studied within an enormous range of dimensions, covering microscopic,
macroscopic, and cosmic dimensions as well as enormous time spans ranging from
nano-/picosecond shock durations (such as produced by ultra-short laser pulses) to shock
durations that continue for centuries (such as blast waves emitted from ancient supernova
explosions). This paper reviews these developments from a historical perspective