Metastasizing Maxillary Ameloblastoma: Report of a Case with Molecular Characterization

Ameloblastoma is a benign odontogenic tumour that may exhibit aggressive biological behaviour with local recurrence and metastasis following initial surgical resection. Surgery is the most acceptable modality of treatment, even if a biological approach is currently on study. We report a case of maxillary ameloblastoma with development of neck and brain metastases after repeated local recurrences. Molecular analysis was performed with the aim to better characterize this neoplasm and its peculiar behaviour

Sclerosing Paraganglioma of the Carotid Body: A Potential Pitfall of Malignancy

Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised. Grossly, the lesion measured 1.8 cm at maximum diameter. On microscopic examination, irregular nests and tiny bundles of neoplastic cells were found between thick bands of fibrous tissue. Focal nuclear cytomegaly and marked pleomorphism were noted. Neoplastic cells proved to be immunoreactive for chromogranin, synaptophysin and neuron specific enolase, but negative for cytokeratins, smooth muscle actin and CD34. Ultrastructurally, numerous mitochondria, rough endoplasmic reticulum structures and endocrine granules were seen in the cytoplasm of the tumour cells. On consideration of the above-mentioned clinico-pathological and ultrastructural findings a diagnosis of sclerosing PG was established. Sclerosing PG is a rare entity which may mimic a malignant neoplasm. The recognition of this unusual morphological variant of PG, together with appropriate immunostains, leads to the correct diagnosis

LONG-TERM FOLLOW-UP OF KIDNEY GRAFTS IN HIGH-RISK PATIENTS UNDER TLI AND CSA THERAPY

[No abstract available

IS UNRELATED LIVING DONOR A VALID ORGAN SOURCE IN RENAL TRANSPLANTATION UNDER CyA THERAPY?

Though there are several advantages to using liver donors in kidney transplantation, the foremost effort is to improve the persistent shortage of cadaveric d o n o r s . 1 2 Nevertheless, the use of living unrelated donors (LURDs) remains controversial, even though under cyclosporine (CyA) regimen, on the theoretical basis that the functional survival rates for grafts transplanted between zero haplotype pairs would be lower than those of one haplotype matched pairs.1 Following our previous studies on living donors,4 ''* our entire experience is reported here in order to evaluate whether grafts matched for one or zero haplotypes with LURDs are as successful as transplantation in recipients of well H L A matched sibling kidneys (LRD). In addition the analysis has been performed according to the immunosuppression protocol used in the recipien

INFLUENCE OF TOTAL LYMPHOID IRRADIATION PLUS CYCLOSPORINE ON KIDNEY GRAFT OUTCOME IN HIGH-RISK PATIENTS

[No abstract available