Scholars Journal of Medical Case Reports ISSN 2347-9507 (Print) Breast Plasmacytoma: Multiple Myeloma Comes Back

Abstract: Extramedullary plasmacytomas are malignant proliferations of plasma cells outside the skeletal tissue. They commonly involve upper respiratory tract and oral cavity. Extramedullary plasmacytomas involving the breast are very uncommon. Here we present a report of extramedullary plasmacytoma of breast in a 53 year old multiple myeloma patient. FNAC and trucut biopsy helped in accurately diagnosing as plasmacytoma of breast

A study of Bcl-2 and p-53 immunostaining expressions in colonic carcinomas

Background: Colorectal cancer burden has been steadily rising in women. It was the fourth most common cancer in 1975 and has reached the second position by 1990, with about 49% increase in the number of cases globally over a period of 15 yrs. From 1999–2008, the rate of people dying from colorectal cancer has varied, depending on their race and ethnicity. Objective: To study Bcl-2 and p-53 immunostaining expressions in colonic carcinomas. Methods: The present study is both a retrospective and a prospective study. The study is based on histomorphological evaluation of 30 resected specimen of Colorectal Carcinomas received at the department of Pathology, Osmania General Hospital in a 2 year period from June 2009 to May 2011. The most representative block for all 30 cases was then selected for immune histochemical analysis of p-53 protein and Bcl-2 Oncoprotein for p-53 immunostaining, we used the DO-7 monoclonal antibody (dilution 1:30; DAKO), and, for Bcl-2, the monoclonal antibody 124 was used (dilution 1:80; DAKO). Results: Positive staining for p-53 protein was detected in 56.67% ( 17/30 ) of colorectal adenocarcinomas. There is statistically no significant association observed between p53 expression and Dukes' stage, TNM stage or Histological grade (p value > 0.05). Similarly no association was found between expression of p-53 and other patient variables, such as age, sex, location of tumor, & tumor differentiation. In the present study statistically there is no significant association between Bcl-2 & p-53 either individually or combined together with any of the parameters (like age, sex, tumor location, Dukes' stage, Histological grade & TNM stage). Conclusion: Though not statistically significant, to comment as the optimism expressed by certain investigators due to the low number of cases taken up for the present study, a large study group is needed to comment on the prognostic significance of the Bcl-2 & p-53 immuno profile individually and in a combined variation to predict the clinical outcome