Using Old Schröder-Reuleaux Models in Modern Kinematics Lectures

The paper deals with the use for educational purposes of kinematic models of the Schroder/Reuleax collection preserved at the Department of Mechanical and Aerospace Engineering of Politecnico di Torino. The article first traces a brief history of the models, which were acquired at the end of the 19th C. by the Regio Museo Industriale of Turin. Four straight-line mechanisms of the collection, employed in modern kinematics lectures, are presented in detail. The didactic method adopted starts from the analysis of the models of the collection and leads the students to develop schemes and software models, in a process of transition from real to virtual. The simulation results are then interpreted and correlated with the functioning of the real model

Stability analysis of a pneumatically actuated inverted pendulum

This paper deals with the stabilization of an inverted pendulum on cart; the latter is pneumatically actuated by a double acting cylinder controlled by low cost proportional valves. In particular, a numerical model of whole system is developed in order to find the ability of the pneumatic actuation in stabilizing the pendulum and evaluate its bandwidth. A cascade of two control loops (the inner one for the pendulum angle, the outer one for the cart displacement) are analyzed and proper compensators are defined. The possibility of introducing an additional loop to control the force exerted by the actuator on the cart is evaluated

Unbalance Response Analysis of a Spindle Supported on Gas Bearings: A Comparison between Different Approaches

Gas journal bearings are widely employed in high-speed spindles for the micromachining industry. Compared to their oil and rolling counterparts, gas bearings have a longer life span, lower friction and a lower level of noise. In order to design accurate high-speed spindles supported by externally pressurized gas bearings, it is vital to analyze the characteristics of rotor bearing systems. In this paper, we present an analysis of the unbalance response of a high-speed spindle supported by gas journal bearings. A number of aspects to enhance the accuracy of the system are discussed. We performed the analysis by considering a nonlinear and a linearized numerical model validated through experimental measurements

On the Design of a Diaphragm Valve for Aerostatic Bearings

Because of their almost zero friction, cleanness and long life, aerostatic bearings are commonly used in many applications where high precision of positioning is required, e.g. machine tools, measuring machines, semiconductor manufacturing and power board testing. However, air bearings suffer from low relative stiffness and poor damping. Active and passive compensation are two effective methods to enhance the static and dynamic performance of these kinds of bearings. Despite their higher performance, active compensation solutions are too expensive to be used in industrial applications, as a consequence of the costs related to their controllers, actuators and sensors. This paper presents the design and performance of a passive compensation method that exploits a diaphragm valve. Thanks to its ease of integration, satisfactory performance and relatively low cost, this method could be a valuable solution to increasing the stiffness of aerostatic bearings. This work provides a procedure to design diaphragm valves depending on the type of the integrated pad and the desired nominal air gap height. Results demonstrate that, once correctly designed, the diaphragm valve makes it possible to obtain bearings with quasi-static infinite stiffness at the selected air gap height

An aerostatic pad with an internal pressure control

Because of their almost zero friction and wear, aerostatic pads are widely used in applications where very precise positioning is required. However, this kind of bearing suffers from poor damping and low specific stiffness. This paper presents a new compensation strategy to increase air pad stiffness. This method exploits a custom-built pneumatic valve which can be easily integrated with any commercial pad. The design and the working principle of the proposed system are described and studied with the aid of a lumped parameter model. The effectiveness of the proposed compensation is numerically and experimentally evaluated. The results demonstrate that the solution represents a good and cost-effective method to enhance the static stiffness of aerostatic pads

Air Pad Controlled by Means of a Diaphragm-Valve: Static and Dynamic Behaviour

This paper presents the analysis of the static and dynamic performance of a passively compensated air pad. The proposed method consists in the integration of a custom-built diaphragm valve and a commercial aerostatic pad. A lumped model is used to simulate the static and dynamic performance of the pad. Results demonstrate that the proposed method is very effective when the system works with excitation frequencies below 10 Hz

A Fully Integrated Electrochemical BioMEMS Fabrication Process for Cytokine Detection: Application for Heart Failure

AbstractIn this present study, a fully integrated BioMEMS was developed using silicon technology to simultaneously detect varying cytokine biomarkers: interleukin-1 (IL-1), interleukin-10 (IL-10), and interleukin-6 (IL-6) using eight gold working microelectrodes (WE). The biomarkers are one of many antigens that are secreted in acute stages of inflammation after left ventricle assisted device (LVAD) implantation for patients suffering from heart failure (HF). The monoclonal antibodies (mAb): anti-human IL-1, IL-10, and IL-6 were immobilized onto gold microelectrodes through functionalization with carboxyl diazonium, respectively. Cyclic voltammetry (CV) was applied during the microelectrode functionalization process to characterize the gold microelectrode surface properties, while electrochemical impedance spectroscopy (EIS) was used to characterize the modified gold microelectrodes. The BioMEMS was highly sensitive towards the three cytokines in a range of 1 pg/mL to 15 pg/mL, which is the window where acute inflammations were observed

Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action

Mastiha is a natural nutritional supplement with known anti-inflammatory properties. Non-alcoholic fatty liver disease (NAFLD) and Inflammatory bowel disease (IBD) are immune mediated inflammatory diseases that share common pathophysiological features. Mastiha has shown beneficial effects in both diseases. MicroRNAs have emerged as key regulators of inflammation and their modulation by phytochemicals have been extensively studied over the last years. Therefore, the aim of this study was to investigate whether a common route exists in the anti-inflammatory activity of Mastiha, specifically through the regulation of miRNA levels. Plasma miR-16, miR-21 and miR-155 were measured by Real-Time PCR before and after two double blinded and placebo-controlled randomized clinical trials with Mastiha. In IBD and particularly in ulcerative colitis patients in relapse, miR-155 increased in the placebo group (p = 0.054) whereas this increase was prevented by Mastiha. The mean changes were different in the two groups even after adjusting for age, sex and BMI (p = 0.024 for IBD and p = 0.042). Although the results were not so prominent in NAFLD, miR-155 displayed a downward trend in the placebo group (p = 0.054) whereas the levels did not changed significantly in the Mastiha group in patients with less advanced fibrosis. Our results propose a regulatory role for Mastiha in circulating levels of miR-155, a critical player in T helper-17 (Th17) differentiation and function