Space shuttle abort separation pressure investigation. Volume 2, Part B: Orbiter data at Mach 5

For abstract, see

Entanglement and Symmetry: A Case Study in Superselection Rules, Reference Frames, and Beyond

This paper concentrates on a particular example of a constraint imposed by superselection rules (SSRs): that which applies when the parties (Alice and Bob) cannot distinguish among certain quantum objects they have. This arises naturally in the context of ensemble quantum information processing such as in liquid NMR. We discuss how a SSR for the symmetric group can be applied, and show how the extractable entanglement can be calculated analytically in certain cases, with a maximum bipartite entanglement in an ensemble of N Bell-state pairs scaling as log(N) as N goes to infinity . We discuss the apparent disparity with the asymptotic (N >> 1) recovery of unconstrained entanglement for other sorts of superselection rules, and show that the disparity disappears when the correct notion of applying the symmetric group SSR to multiple copies is used. Next we discuss reference frames in the context of this SSR, showing the relation to the work of von Korff and Kempe [Phys. Rev. Lett. 93, 260502 (2004)]. The action of a reference frame can be regarded as the analog of activation in mixed-state entanglement. We also discuss the analog of distillation: there exist states such that one copy can act as an imperfect reference frame for another copy. Finally we present an example of a stronger operational constraint, that operations must be non-collective as well as symmetric. Even under this stronger constraint we nevertheless show that Bell-nonlocality (and hence entanglement) can be demonstrated for an ensemble of N Bell-state pairs no matter how large N is. This last work is a generalization of that of Mermin [Phys. Rev. D 22, 356 (1980)].Comment: 16 pages, 6 figures. v2 updated version published in Phys Rev

Space shuttle abort separation pressure investigation. Volume 6: Orbiter data at Mach 2

For abstract, see

Investigation of the McDonnell-Douglas orbiter and booster shuttle models in proximity at Mach numbers 2.0 to 6.0. Volume 7: Proximity data at Mach 4 and 6, interference free and launch vehicle data

Aerodynamic data obtained from a space shuttle abort stage separation wind tunnel test are presented. The .00556 scale models of the orbiter and booster configuration were tested in close proximity using dual balances during the time period of April 21 to April 27 1971. Data were obtained for both booster and orbiter over an angle of attack range from -10 to 10 deg for zero degree sideslip angle. The models were tested at several relative incidence angles and separation distances and power conditions. Plug nozzles utilizing air were used to simulate booster and orbiter plumes at various altitudes along a nominal ascent trajectory. Powered conditions were 100, 50, 25 and 0 percent of full power for the orbiter and 100, 50 and 0 percent of full power for the booster. Pitch control effectiveness data were obtained for both booster and orbiter with power on and off. In addition, launch vehicle data with and without booster power were obtained utilizing a single balance in the booster model. Data were also obtained with the booster canard off in close proximity and for the launch configuration

Space shuttle abort separation pressure investigation. Volume 1, Part B: Booster data at Mach 5

For abstract, see

Space shuttle abort separation pressure investigation. Volume 3: Booster data at Mach 3

For abstract, see

Space shuttle abort separation pressure investigation. Volume 1, Part A: Booster data at Mach 5

Pressure data obtained from a joint Langley Research Center (LaRC)/Marshall Space Flight Center (MSFC) Space Shuttle about stage separation wind tunnel test are presented. The .00556 scale models of the McDonnell-Douglas orbiter and booster configurations were tested in proximity in Tunnel A of the Von Karman Facility (VKF), Arnold Engineering Development Center (AEDC). Mach numbers were 5.0, 3.0, and 2.0 and nominal Reynolds numbers were 1.09, 1.60, and 1.74 million per foot, respectively. Pressure data were obtained for the booster upper surface and orbiter lower surface at angles of attack of -10 deg, -5, 0, 5, and 10 deg for zero degrees sideslip. The models were tested at incidence angles of 0 and 5 deg for several separation distances and power conditions. Plug nozzles utilizing air were used to simulate booster and orbiter plumes at various altitudes along a nominal ascent trajectory. Powered conditions were 100, 50, and 0 percent of full power for the orbiter and 100, 50 and 0 percent of full power for the booster. Data were also obtained with the booster canard off in close proximity

Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function

Temporal lobe epilepsy (TLE) is a prevalent neurological disorder with many patients experiencing poor seizure control with existing anti-epileptic drugs. Thus, novel insights into the mechanisms of epileptogenesis and identification of new drug targets can be transformative. Changes in ion channel function have been shown to play a role in generating the aberrant neuronal activity observed in TLE. Previous work demonstrates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability and are mislocalized within CA1 pyramidal cells in a rodent model of TLE. The subcellular distribution of HCN channels is regulated by an auxiliary subunit, tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b), and disruption of this interaction correlates with channel mislocalization. However, the molecular mechanisms responsible for HCN channel dysregulation in TLE are unclear. Here we investigated whether changes in TRIP8b phosphorylation are sufficient to alter HCN channel function. We identified a phosphorylation site at residue Ser237 of TRIP8b that enhances binding to HCN channels and influences channel gating by altering the affinity of TRIP8b for the HCN cytoplasmic domain. Using a phosphospecific antibody, we demonstrate that TRIP8b phosphorylated at Ser237 is enriched in CA1 distal dendrites and that phosphorylation is reduced in the kainic acid model of TLE. Overall, our findings indicate that the TRIP8b-HCN interaction can be modulated by changes in phosphorylation and suggest that loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis. These results highlight the potential of drugs targeting posttranslational modifications to restore TRIP8b phosphorylation to reduce excitability in TLE

Cognitive appraisal of environmental stimuli induces emotion-like states in fish

The occurrence of emotions in non-human animals has been the focus of debate over the years. Recently, an interest in expanding this debate to non-tetrapod vertebrates and to invertebrates has emerged. Within vertebrates, the study of emotion in teleosts is particularly interesting since they represent a divergent evolutionary radiation from that of tetrapods, and thus they provide an insight into the evolution of the biological mechanisms of emotion. We report that Sea Bream exposed to stimuli that vary according to valence (positive, negative) and salience (predictable, unpredictable) exhibit different behavioural, physiological and neuromolecular states. Since according to the dimensional theory of emotion valence and salience define a two-dimensional affective space, our data can be interpreted as evidence for the occurrence of distinctive affective states in fish corresponding to each the four quadrants of the core affective space. Moreover, the fact that the same stimuli presented in a predictable vs. unpredictable way elicited different behavioural, physiological and neuromolecular states, suggests that stimulus appraisal by the individual, rather than an intrinsic characteristic of the stimulus, has triggered the observed responses. Therefore, our data supports the occurrence of emotion-like states in fish that are regulated by the individual's perception of environmental stimuli.European Commission [265957 Copewell]; Fundacao para a Ciencia e Tecnologia [SFRH/BD/80029/2011, SFRH/BPD/72952/2010]info:eu-repo/semantics/publishedVersio