La información de medicamentos y las revistas profesionales farmacéuticas

Se describen las características y se cuantifican los contenidos de II revistas profesionales fannacéuticas recibidas, gratuitamente, en una oficina de fannacia durante un año. Los 110 números recibidos incluían 7.463 páginas cuyos contenidos han sido clasificados en: noticias fannacéuticas, anuncios publicitarios, fichas monográficas, artículos técnicos, artículos de opinión y otros contenidos. Las revistas profesionales fannacéuticas constituyen un material infonnativo muy voluminoso, pero también muy útil, pudiendo colaborar en la fonnación continuada de los fannacéuticos.The characteristics and the contents of eleven phannaceutical professional journals received gratuitously in a community phannacy for a year, have been described and evaluated. The contents of I 10 issues whit 7.463 pages have been classified in phannaceutical news, drug advertisements, monograph cards, technical articles, view articles and other contents. The phannaceutical professional joumals are a very voluminous infonnation, but very usseful too, helping to the continued fonnation of the phannacist

Heteroaromatic polyamides with Improved thermal and mechanical properties

We prepared high-performance aromatic copolyamides, containing bithiazole and thiazolo-thiazole groups in their main chain, from aromatic diamines and isophthaloyl chloride, to further improve the prominent thermal behavior and exceptional mechanical properties of commercial aramid fibers. The introduction of these groups leads to aramids with improved strength and moduli compared to commercial meta-oriented aromatic polyamides, together with an increase of their thermal performance. Moreover, their solubility, water uptake, and optical properties were evaluated in this work.Fondo Europeo de Desarrollo Regional and both the Spanish Ministerio de Economía, Industria y Competitividad (MAT2017-84501-R) and the Consejería de Educación, Junta de Castilla y León (BU306P18) is gratefully acknowledged. M.T.L. also thankfully acknowledges the Spanish Ministerio de Ciencia e Innovación (PID2019-108583RJ-I00/AEI/10.13039/501100011033

Aplicación de hielo incluyendo conservantes naturales para la mejora de la calidad de especies marinas refrigeradas

6 páginas, 4 figurasComo resultado de la creciente demanda de productos marinos frescos de alta calidad, la tecnología de alimentos ha desarrollado una gran diversidad de estrategias novedosas de refrigeración que han contribuido al desarrollo continuado y a la innovación en el sector. En este trabajo se describe la actividad llevada a cabo en los últimos años en nuestro grupo de trabajo. En él, se desarrolló una estrategia nueva consistente en emplear como medio de refrigeración hielo preparado a partir de disoluciones acuosas incluyendo componentes conservantes naturales de distinta procedencia (extractos vegetales, ácidos orgánicos de pequeño tamaño y extractos de macroalgas)Los experimentos fueron financiados por la Secretaría Xeral de I+D de la Xunta de Galicia (Galicia, España) (Proyecto 10 TAL 018E), el Consejo Superior de Investigaciones Científicas (CSIC; Proyecto PIE 201370E001) y el Programa de Cooperación Hispano-Chileno “Universidad de Chile-Consejo Superior de Investigaciones Científicas (CSIC) (Proyecto 2004 CL 0038).Peer reviewe

Quemador poroso

Quemador poroso adaptado para ser alimentado con diferentes tipos de gases, que comprende un soporte que incluye un conducto a través del cual entra una mezcla de aire/gas en el quemador poroso, y una estructura cerámica, soportada por el soporte, que comprende una esponja inicialmente polimérica que se impregna con una barbotina, comprendiendo dicha barbotina al menos un material cerámico. La estructura cerámica tiene una porosidad final de entre aproximadamente 50 ppi hasta aproximadamente 70 ppi, y una densidad final de entre aproximadamente 0.45 hasta aproximadamente 0.65 g/cm3.Peer reviewedConsejo Superior de Investigaciones Científicas (España), P.I. Prosider Ibérica S.A, Ikerlan S COOPB1 Patente sin examen previ

The evolution of the North Atlantic Oscillation for the last 700 years inferred from D/H isotopes in the sedimentary record of Lake Azul (Azores archipelago, Portugal).

TheD plant leaf wax variations provide insights on precipitation and evaporation evolution through time. This proxy has been used to reconstruct the temporal evolution of the North Atlantic Oscillation (NAO) climate mode since this mode rules most of the climate variability in the central North Atlantic area. A total lipid extraction preparation and the correspondent analyses in the IRMS have been done for 100 samples from the uppermost 1.5 m of the sedimentary infill of Lake Azul (Azores archipelago, Portugal). According to the chronological model, established by 210Pb profile and 4 AMS 14C dates, this record contains the environmental history of the last 730 years. The reconstructed precipitation variations obtained from D/H isotope values, suggest that this area has suffered significant changes in its distribution and intensity rainfall patterns through time. The end of the Medieval Climate Anomaly (MCA, 1100- 1300 AD) is characterized by a progressive enrichmentof D/H isotope values which meant decreasing arid conditions. These rainfalls’ increase might be interpreted by a shift from positive to negative dominance of the NAO. The Little Ice Age (LIA, 1300 - 1850 AD) was characterized by two humid periods (1300- 1550 AD and 1650 - 1850 AD) separated by a relatively dry period. These precipitation oscillations are clearly visible by marked changes in the D/H isotope values. The LIA was followed by the persistence of the positive NAO mode, exhibited by the depletion of the D/H isotope signal, which indicated an overall decrease of the precipitation in the central North Atlantic area. Surprisingly, the D/H of the last 100 years, characterized by the present global warming and a persistent positive NAO mode, display large fluctuations most possibly linked to an enhancement of the storminess which is in concordance with the data fluctuations observed in the instrumental record for the last 80 years in the archipelago. This climatic evolution is in accordance with other NAO records of the North Atlantic region (Trouet et al., 2012) highlighting the validity of the D/H isotopes as precipitation proxy.Peer Reviewe

Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase

Flavoproteins participate in a wide variety of physiologically relevant processes that typically involve redox reactions. Within this protein superfamily, there exists a group that is able to transfer reducing equivalents from FAD to a redox-active disulfide bridge, which further reduces disulfide bridges in target proteins to regulate their structure and function. We have identified a previously undescribed type of flavin enzyme that is exclusive to oxygenic photosynthetic prokaryotes and that is based on the primary sequence that had been assigned as an NADPH-dependent thioredoxin reductase (NTR). However, our experimental data show that the protein does not transfer reducing equivalents from flavins to disulfides as in NTRs but functions in the opposite direction. High-resolution structures of the protein from Gloeobacter violaceus and Synechocystis sp. PCC6803 obtained by X-ray crystallography showed two juxtaposed FAD molecules per monomer in redox communication with an active disulfide bridge in a variant of the fold adopted by NTRs. We have tentatively named the flavoprotein “DDOR” (diflavin-linked disulfide oxidoreductase) and propose that its activity is linked to a thiol-based transfer of reducing equivalents in bacterial membranes. These findings expand the structural and mechanistic repertoire of flavoenzymes with oxidoreductase activity and pave the way to explore new protein engineering approaches aimed at designing redox-active proteins for diverse biotechnological applications

Emploi de glace portant des acides organiques naturels pendant l’entreposage de poisson à bord

Presentación de la conferencia dictada en el Colloque QSPA, Qualité et Sécurité des Produits Aquatiques, Boulogne (France), 18 juin 2015Peer reviewe

Drought impacts on vegetation activity, growth and primary production in humid and arid ecosystems

9 Pags., 5 Figs.[EN] We have evaluated the response of the Earth biomes to drought using a new global dataset that captures drought effects on vegetation at various time scales. We show that arid and humid biomes are both affected by drought, and that the time scale on which droughts most intensively affects vegetation plays a key role in determining the sensitivity of biomes to drought. Arid biomes respond to drought at short time scales because plants have mechanisms allowing them to rapidly adapt to changing water availability. Humid biomes also respond to drought at short time scales, probably because there plant species show a poor adaptability to water shortage. Sub-humid biomes respond to drought at long time scales because plants are adapted to withstand water deficit, but they lack the rapid post-drought recovery observed in arid biomes.[ES] En este trabajo se evalúa la respuesta de los diferentes biomas terrestre a la sequía mediante una base de datos nueva que captura el efecto de la sequía sobre la vegetación a diferentes escalas temporales. Se ha comprobado que los biomas característicos de zonas áridas y húmedas se ven afectados por la sequía, y que la escala temporal de la sequía juega un papel clave al determinar la sensibilidad de los biomas a la sequía. Los biomas áridos responden a las sequías medidas a escalas temporales cortas, debido a que las plantas tienen mecanismos que les permitan adaptarse rápidamente a la disponibilidad de agua. Los biomas húmedos también responden a la sequía a escalas temporales cortas, probablemente debido a que las especies ubicadas allí muestran una mala adaptación a la escasez de agua. Los biomas subhúmedos responden a la sequía a escalas de tiempo más largas, porque las plantas están adaptadas para soportar el déficit de agua, pero carecen de la rápida recuperación observada tras la sequía en los biomas áridos.This work was supported by projects financed by the Spanish Commission of Science and Technology (CGL2O1 1-27574-C02-02, CGL2O1 1-27536 and CGL2O1 1-26654) and the Aragón Government. J.J.C. thanks the support of ARAID and A.S-L. was supported by a postdoctoral fellowship from the Generalitat de Catalunya (2009 BP-A 00035).Peer reviewe

Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase

Flavoproteinsparticipateinawidevarietyofphysiologicallyrelevant processes that typically involve redox reactions. Within this protein superfamily, there exists a group that is able to transfer reducing equivalents from FAD to a redox-active disulfide bridge, which further reduces disulfide bridges in target proteins to regulate their structure and function. We have identified a previously undescribed type of flavin enzyme that is exclusive to oxygenic photosynthetic prokaryotes and that is based on the primary sequence that had been assigned as an NADPH-dependent thioredoxin reductase (NTR). However, our experimental data show that the protein does not transfer reducing equivalents from flavins to disulfides as in NTRs but functions in the opposite direction. High-resolution structures of the protein from Gloeobacter violaceus and Synechocystis sp. PCC6803 obtained by X-ray crystallography showed two juxtaposed FADmoleculespermonomerinredoxcommunicationwithanactive disulfide bridge in a variant of the fold adopted by NTRs. We have tentatively named the flavoprotein “DDOR” (diflavin-linked disulfide oxidoreductase) and propose that its activity is linked to a thiol-basedtransferofreducingequivalentsinbacterialmembranes. These findings expand the structural and mechanistic repertoire of flavoenzymes with oxidoreductase activity and pave the way to explore new protein engineering approaches aimed at designing redox-active proteins for diverse biotechnological applications.Spanish Ministerio de Economía, Industria y Competitividad BFU2016-80343-P, BIO2016-75634-