Reliable Execution of Business Processes on Dynamic Networks of Service-Enabled Devices

Abstract—It is expected that future shop-floors will be populated by thousands of networked embedded devices. Those will not only communicate using IP (as in TCP/IP), but also feature some autonomy, allowing them to collaborate among themselves and with enterprise systems. As they can offer both their mechatronic and higher-level functions as a service and support dynamic deployment of new code, they can execute business logic locally, allowing for new classes of business processes that are executed collaboratively by back-end and embedded systems. While some parts of a process will still be executed in the data centre, the rest will execute directly on embedded devices on the shop-floor. Business Process execution will therefore be more dynamic and context-based. We introduce an approach to manage efficient business process execution over such highly dynamic infrastructures. Service Type able to execute T 1 Process step S 1 s 1,

Adult acute megakaryoblastic leukemia: rare association with cytopenias of undetermined significance and p210 and p190 BCR–ABL transcripts

Delia Dima,1,* Liana Oprita,2,* Ana-Maria Rosu,3,* Adrian Trifa,4 Cristina Selicean,1 Vlad Moisoiu,3 Ioana Frinc,1 Mihnea Zdrenghea,1,5 Ciprian Tomuleasa1,3,5 1Department of Hematology, Ion Chiricuta Oncology Institute, 2Department of Dentistry, 3Research Center for Functional Genomics and Translational Medicine, 4Department of Genetics, 5Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania *These authors contributed equally to this work Abstract: Acute megakaryocytic leukemia (M7-AML) is a rare form of acute myeloid leukemia (AML), which is associated with poor prognosis. The case presented in the current report is a statement for the difficult diagnosis and clinical management of M7-AML in the context of a previous hematologic disorder of undetermined significance and associated genetic abnormalities. Probably, following the complete hematologic remission and further with induction chemotherapy plus tyrosine kinase inhibitor therapy, the clinical management of this case will be followed by a allogeneic bone marrow transplantation, the only proven therapy to improve overall survival. Keywords: acute megakaryocytic leukemia, BCR–ABL transcript&nbsp

Nitrogen assimilation under different nitrate nutrition in Tunisian durum wheat landraces and improved genotypes

The effects of nitrate were studied in wheat varieties grown in hydroponic culture: two landraces (Azizi and Bidi), and two improved genotypes (Om Rabiaa and Khiar) from Tunisia. Nitrogen (N) supply generally induced an increase in plant height in all varieties, albeit to a different extent; interestingly, landraces exhibited the same N Uptake Efficiency (NUpE) as other varieties, and a lower Nitrogen Utilization Efficiency (NUtE); in contrast, improved genotypes exhibit a better NUtE at high N. Nitrate reductase activity (NRA) was sensibly and constitutively higher in the improved genotypes in the roots, while NRA was strongly influenced by nitrate supply in the leaves of Bidi landrace. Glutamine synthetase (GS) activity was similar in all varieties studied, in contrast, ferredoxin-glutamate synthase (Fd- GOGAT) activity and occurrence were increased by nitrate. Intriguingly, glutamate dehydrogenase (GDH) activity followed an opposite behaviour with respect to GOGAT. Glucose-6P-dehydrogenase (G6PDH), which provides reductants for N assimilation, increased in roots upon nitrate supply, but the different plastidial and cytosolic isoforms differently changed in the different varieties studied. The data suggest that landraces present higher metabolic flexibility as compared with improved cultivars; therefore, the metabolic changes observed could be suitable for the identification of factors limiting the NUtE