Inertial waves in a laboratory model of the Earth's core

A water-filled three-meter diameter spherical shell built as a model of the Earth's core shows evidence of precessionally forced flows and, when spinning the inner sphere differentially, inertial modes are excited. We identified the precessionally forced flow to be primarily the spin-over inertial mode, i.e., a uniform vorticity flow whose rotation axis is not aligned with the container's rotation axis. A systematic study of the spin-over mode is carried out, showing that the amplitude dependence on the Poincaré number is in qualitative agreement with Busse's laminar theory while its phase differs significantly, likely due to topographic effects. At high rotation rates free shear layers concentrating most of the kinetic energy of the spin-over mode have been observed. When spinning the inner sphere differentially, a total of 12 inertial modes have been identified, reproducing and extending previous experimental results. The inertial modes excited appear ordered according to their azimuthal drift speed as the Rossby number is varied

The coupling between inertial and rotational eigenmodes in planets with liquid cores

The Earth is a rapidly rotating body. The centrifugal pull makes its shape resemble a flattened ellipsoid and Coriolis forces support waves in its fluid core, known as inertial waves. These waves can lead to global oscillations, or modes, of the fluid. Periodic variations of the Earth's rotation axis (nutations) can lead to an exchange of angular momentum between the mantle and the fluid core and excite these inertial modes. In addition to viscous torques that exist regardless of the shape of the boundaries, the small flattening of the core-mantle boundary (CMB) allows inertial modes to exert pressure torques on the mantle. These torques effectively couple the rigid-body dynamics of the Earth with the fluid dynamics of the fluid core. Here we present the first high resolution numerical model that solves simultaneously the rigid body dynamics of the mantle and the Navier-Stokes equation for the liquid core. This method takes naturally into account dissipative processes in the fluid that are ignored in current nutation models. We find that the Free Core Nutation (FCN) mode, mostly a toroidal fluid flow if the mantle has a large moment of inertia, enters into resonance with nearby modes if the mantle's moment of inertia is reduced. These mode interactions seem to be completely analogous to the ones discovered by Schmitt (2006) in a uniformly rotating ellipsoid with varying flattening.Comment: 30 pages, 19 figures. Published in the Geophysical Journal Internationa

Tight asteroseismic constraints on core overshooting and diffusive mixing in the slowly rotating pulsating B8.3V star KIC 10526294

KIC 10526294 is a very slowly rotating and slowly pulsating late B-type star. Its 19 consecutive dipole gravity modes constitute a series with almost constant period spacing. This unique collection of identified modes probes the near-core environment of this star and holds the potential to reveal the size and structure of the overshooting zone on top of the convective core, as well as the mixing properties of the star. We pursue forward seismic modelling based on adiabatic eigenfrequencies of equilibrium models for eight extensive evolutionary grids tuned to KIC 10526294, by varying the initial mass, metallicity, chemical mixture, and the extent of the overshooting layer on top of the convective core. We examine models for both OP and OPAL opacities and test the occurrence of extra diffusive mixing. We find a tight mass, metallicity relation within the ranges $M$ ~ 3.13 to 3.25 Msun and $Z$ ~ 0.014 to 0.028. We deduce that an exponentially decaying diffusive core overshooting prescription describes the seismic data better than a step function formulation and derive a value of $f_{ov}$ between 0.017 and 0.018. Moreover, the inclusion of extra diffusive mixing with a value of $\log D_{\rm mix}$ between 1.75 and 2.00 dex (with $D_{\rm mix}$ in cm^2/sec) improves the goodness-of-fit based on the observed and modelled frequencies with a factor 11 compared to the case where no extra mixing is considered, irrespective of the $(M,Z)$ combination within the allowed seismic range. The inclusion of diffusive mixing in addition to core overshooting is essential to explain the structure in the observed period spacing pattern of this star. Moreover, we deduce that an exponentially decaying prescription for the core overshooting is to be preferred over a step function. Our best models for KIC 10526294 approach the seismic data to a level that they can serve future inversion of its stellar structure.Comment: 13 pages, 4 tables, 12 figures, accepted for publication in Astronomy & Astrophyic

Understanding the effects of the core on the nutation of the Earth

In this review paper, we examine the changes in the Earth orientation in space and focus on the nutation (shorter-term periodic variations), which is superimposed on precession (long-term trend on a timescale of years). We review the nutation modelling involving several coupling mechanisms at the core-mantle boundary using the Liouville angular momentum equations for a two-layered Earth with a liquid flattened core. The classical approach considers a Poincaré fluid for the core with an inertial pressure coupling mechanism at the core-mantle boundary. We examine possible additional coupling mechanisms to explain the observations. In particular, we examine how we can determine the flattening of the core as well as information on the magnetic field and the core flow from the nutation observations. The precision of the observations is shown to be high enough to increase our understanding on the coupling mechanisms at the core-mantle boundary

XV International Congress of Control Electronics and Telecommunications: "The role of technology in times of pandemic and post-pandemic: innovation and development for strategic social and productive sectors"

La anterior selección, motivados por la aseveración de Manuel Castells -hace casi 20 años ya- que la innovación y la difusión de la tecnología parecía ser la herramienta apropiada para el desarrollo en la era de la información. Este 2020, sin embargo, ante la situación disruptiva que aquejó y aqueja a la sociedad red como una estructura social emergente de la Era de la Información basada en redes de producción, energizadas por el poder y la experiencia; falló y debe reencontrar su rumbo. Es así que los problemas acuciantes, ahora, fueron: la atención sanitaria y la superación de la epidemia de Sars Cov 2; tomó forma la, hasta entonces, visión irrealista de Castells que … no podemos avanzar con nuestros modelos de desarrollo actual, destruyendo nuestro entorno y excluyendo a la mayor parte de la humanidad de los beneficios de la revolución tecnológica más extraordinaria de la historia, sin sufrir una devastadora reacción por parte de la sociedad y la naturaleza. Fue así que el Cuarto Mundo, específicamente, donde la suficiencia de recurso humano, de capital, trabajo, información y mercado -vinculados todos a través de la tecnología- supuso que atendería eficazmente a través de la población que podía por su capacidad hacer uso racional y profesional del conocimiento, las necesidades de la mayoritaria población vulnerable y vulnerada. Por lo anterior, poner en el centro a las personas, en entornos de tarea y trabajo globales hiperconectados combinando espacios físicos, corrientes de información con canales de conexión expeditos, y formando profesionales del conocimiento que asuman y afronten los retos derivados de la transformación digital de empresas, universidades, y organizaciones, pero en condiciones de equidad y sujetos de prosperidad, será el desafío en los escenarios presentes y futuros inmediatos.The previous selection, motivated by the assertion of Manuel Castells -almost 20 years ago- that innovation and diffusion of technology seemed to be the appropriate tool for development in the information age. This 2020, however, in the face of the disruptive situation that afflicted and continues to afflict the network society as an emerging social structure of the Information Age based on production networks, energized by power and experience; He failed and must find his way again. Thus, the pressing problems now were: health care and overcoming the Sars Cov 2 epidemic; Castells' until then unrealistic vision took shape that... we cannot advance with our current development models, destroying our environment and excluding the majority of humanity from the benefits of the most extraordinary technological revolution in history, without suffering a devastating reaction from society and nature. It was thus that the Fourth World, specifically, where the sufficiency of human resources, capital, work, information and market - all linked through technology - meant that it would serve effectively through the population that could, due to its capacity, make rational use. and knowledge professional, the needs of the majority vulnerable and vulnerable population. Therefore, putting people at the center, in hyperconnected global task and work environments, combining physical spaces, information flows with expedited connection channels, and training knowledge professionals who assume and face the challenges derived from the digital transformation of companies, universities, and organizations, but in conditions of equality and subject to prosperity, will be the challenge in the present and immediate future scenarios.Bogot

Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo

BACKGROUND: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. METHODS: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy. RESULTS: Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m(2), and duration of T2DM was 9.3 ± 8.2 years. The qualifying ACS was a myocardial infarction in 83% and unstable angina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events. CONCLUSION: ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research