7 research outputs found
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Wind-Blown Bubbles around Evolved Stars
Most stars will experience episodes of substantial mass loss at some point in
their lives. For very massive stars, mass loss dominates their evolution,
although the mass loss rates are not known exactly, particularly once the star
has left the main sequence. Direct observations of the stellar winds of massive
stars can give information on the current mass-loss rates, while studies of the
ring nebulae and HI shells that surround many Wolf-Rayet (WR) and luminous blue
variable (LBV) stars provide information on the previous mass-loss history. The
evolution of the most massive stars, (M > 25 solar masses), essentially follows
the sequence O star to LBV or red supergiant (RSG) to WR star to supernova. For
stars of mass less than 25 solar masses there is no final WR stage. During the
main sequence and WR stages, the mass loss takes the form of highly supersonic
stellar winds, which blow bubbles in the interstellar and circumstellar medium.
In this way, the mechanical luminosity of the stellar wind is converted into
kinetic energy of the swept-up ambient material, which is important for the
dynamics of the interstellar medium. In this review article, analytic and
numerical models are used to describe the hydrodynamics and energetics of
wind-blown bubbles. A brief review of observations of bubbles is given, and the
degree to which theory is supported by observations is discussed.Comment: To be published as a chapter in 'Diffuse Matter from Star Forming
Regions to Active Galaxies' - A volume Honouring John Dyson. Eds. T. W.
Harquist, J. M. Pittard and S. A. E. G. Falle. 22 pages, 12 figure
Conceptualizing, investigating, and enhancing adaptive expertise in elementary mathematics education
Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man
Background Individuals who chronically excrete neurovirulent poliovirus of vaccine-origin are of considerable concern to the Global Polio Eradication programme. Chronic infection with such polioviruses is a recognised complication of hypogammaglobulinaernia.Methods We did a series of in-vitro and in-vivo therapeutic studies, with a view to clearing persistent neurovirulent poliovirus infection in an individual with common variable immunodeficiency, using oral immunoglobulin, breast milk (as a source of secretory IgA), ribavirin, and the anti-picornaviral agent pleconaril. We undertook viral quantitation, antibody neutralisation and drug susceptibility assays, and viral gene sequencing.Findings Long-term asymptomatic excretion of vaccine-derived neurovirulent poliovirus 2 was identified in this hypogammaglobulinaemic man, and was estimated to have persisted for up to 22 years. Despite demonstrable in-vitro neutralising activity of immunoglobulin and breast milk, and in-vitro antiviral activity of ribavirin, no treatment was successful at clearing the virus, although in one trial breast milk significantly reduced excretion levels temporarily. During the course of study, the virus developed reduced susceptibility to pleconaril, precluding the in-vivo use of this drug. Sequence analysis revealed the emergence of a methionine to leucine mutation adjacent to the likely binding site of pleconaril in these isolates.Interpretation Chronic vaccine-associated poliovirus infection in hypogammaglobulinaemia is a difficult condition to treat. It represents a risk to the strategy to discontinue polio vaccination once global eradication has been achieved