85 research outputs found
Structural and synthetic insights into pyridine homocouplings mediated by a β-diketiminato magnesium amide complex
Reaction of [(DippNacnac)Mg(TMP)] (1) with 4âsubtituted pyridines proceeds via sequential regioselective metalation and 1,2âaddition to furnish a range of symmetric 4,4'R2â2,2'âbipyridines in good yield, representing a new entry into bipyridine synthesis. Interestingly, the reaction with of 1 with 2âOMeâpyridine led to formation of asymmetric bipyridine 6, resulting from the C6âmagnesiation of the heterocycle followed by a CâC coupling step by addition to the C2 position of a second, nonâmetallated molecule, and subsequent elimination of [DippNacnacMgOMe]2 (7). Synthesis combined with spectroscopic and structural analysis help rationalise the underlying processes resulting in the observed reactivity, and elucidates the key role of the sterically encumbered βâdiketiminate ligand plays in determining regioselectivity
ChemInform Abstract: First Syntheses of Caerulomycin E and Collismycins A and C. A New Synthesis of Caerulomycin A.
ChemInform Abstract: Synthesis of Substituted 8-Methoxyquinolines by Regioselective Bromine- Lithium Exchange of 5,7-Dihalo-8-methoxyquinolines and 7-Bromo-8- methoxyquinoline.
ChemInform Abstract: SYNTHESIS OF DIAZAXANTHONES: 5H-PYRANO(2,3B:6,5-Bâ˛)DIPYRIDIN-5-ONE AND 5H-THIOPYRANO(2,3-B:6,5-Bâ˛)DIPYRIDIN-5-ONE
ChemInform Abstract: Pyridylmagnesium Chlorides from Bromo and Dibromopyridines by Bromine-Magnesium Exchange: A Convenient Access to Functionalized Pyridines.
ChemInform Abstract: New Syntheses of Substituted Pyridines via Bromine-Magnesium Exchange.
ChemInform Abstract: Total Synthesis of (.+-.)-Atpenin B. An Original âClockwiseâ Functionalization of 2-Chloropyridine.
ChemInform Abstract: A New Route to 5,6-Diarylpyridazin-3-ones by Metalation and Cross- Coupling of Pyridazines.
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