29 research outputs found
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Get PDFEffects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
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- Alberti A
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- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
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- Amundson A
- Andersen K
- Andersen M
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- Anderson G
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- Andersson H
- Andersson L
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- Andres C
- Andresen D
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- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
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- Aung HNIN THANDA
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- Zong D
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Get PDFBACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Thigh-length compression stockings and DVT after stroke
- Author
- Abbas M
- Abbasi S
- Abbasi S
- Abdelaziz A
- Abdelfattah M
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- Abdulshukkoor N
- Abdusamad K
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Get PDFControversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Stability of the Defibrillation Probability Curve with the Development of Ventricular Dysfunction in the Canine Rapid Paced Model
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textEffect of Anconeus Muscle Blocking on Elbow Kinematics: Electromyographic, Inertial Sensors and Finite Element Study
- Author
- A Goto
- A Seyahi
- AA Halls
- AA Travill
- AD Armstrong
- Adam C. Watts
- Alan Walmsley
- ATM Phillips
- B Merz
- BF Morrey
- BP Pereira
- C Cael
- CC Schmidt
- CE Dunham
- CE Dunning
- CS Ahmad
- CS Modi
- D Farina
- DA Winter
- DGE Robertson
- EM Spratley
- EW Brabston III
- F Molinier
- GBA Duchenne
- Israel Miguel-Andres
- JA Weiss
- JB Kuipers
- JE Pauly
- JP Fisk
- JV Basmajian
- K Nishida
- KE Fleager
- LQ Zhang
- M Coel
- M Hack
- M Praagman
- MGWS Coriolano
- MJ Bergin
- MR Safran
- MS Cohen
- N Capdarest-Arest
- R Luchetti
- R Merletti
- RD Ray
- S Bell
- S Bozec Le
- S Bozec Le
- S Bozec Le
- SW O’Driscoll
- SW O’Driscoll
- Teresa Alonso-Rasgado
- TF Gleason
- WD Regan
- YC Fung
- Z Zou
- ZT Rao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
No full textThe specific contribution of the anconeus muscle to elbow function is still uncertain.This study aimed to investigate the effect on elbow kinematics and kinetics ofblocking anconeus using lidocaine. Ten healthy volunteers performed experimental trials involving flexion-extension and supination-pronation movements in horizontal and sagittal planes. Inertial sensors and surface electromyography were used to record elbow kinematics and kinetics and electrical activity from the anconeus, biceps and triceps brachii before and after blocking anconeus. Moreover, a finite element model of the elbow was created to further investigate the contribution of anconeus to elbow kinematics.The electrical activity results from the trials before blocking clearly indicated that activity of anconeus was increased during extension, suggesting that it behaves as an extensor. However, blocking anconeus had no effect on the elbow kinematics and kinetics, including the angular velocity, net torque and power of the joint. The electrical activity of the biceps and triceps brachii did not alter significantly following anconeus blocking. These results suggest that anconeus is a weak extensor, and the relative small contribution of anconeus to extension before blocking was compensated by triceps brachii. The finite element results indicated that anconeus does not contribute significantly to elbow kinematics
MRC BHFHeart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience
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- Hulmes J
- Humphrey P
- Hunter A
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- Hunter B
- Hunter J
- Indge C
- Inman A
- Ismail S
- Jamieson J
- Jayne K
- Jewkes C
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- Jones A
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- Joyce E
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- Keeble M
- Keech A
- Kehely A
- Kemp T
- Kenny A
- Kerr J
- Khalifa M
- Kidan AH
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- Labib M
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- Lindley R
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- Pentecost B
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- Publication venue
- Publication date
- 01/01/1999
- Field of study
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