Population pharmacokinetics of amikacin in neonatal intensive care unit patients

Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates

Needs Supplies Fit and Employment Quality: Flexible and Secure Work Environment

ARC - Understanding flexicurit

Individual needs in flexibility and employment security: a qualitative approach

ARC-Understanding flexicurit

"Needs-supplies fit and behavioural outcomes: the mediating role of organizational identification"

ARC-understanding flexicurit

Qualité de l'emploi et perception d'écart entre les besoins et les caractéristiques de l'emploi chez les doctorants: impact sur l'intention de quitter

ARC-understanding flexicurit

Needs-supplies fit and behavioral outcomes: the mediating role of organizational identification

ARC - understanding flexicurit

Importance of work-related needs between job crafting, burnout and engagement

ARC-understanding flexicurit

Needs-Supplies Fit and Behavioral Outcomes: The Mediating Role of Organizational Identification

ARC-understanding flexicurit

Relationships between employment quality and intention to quit: Focus on PhD candidates as traditional workers

Current statistics show that the attrition rate among PhD candidates is high (i.e. from 30% to 40% depending on the discipline and the country). This high-attrition rate has an impact on both economic (e.g. negative impact on the return-on investment in doctoral education) and human levels (e.g. negative consequences on candidates’ self-esteem and well-being). Therefore, it seems important to better understand and to prevent the attrition among PhD candidates. Based on the needs–supplies fit theory, the present research focused on the perception of a fit between several PhD candidates’ work-related needs in terms of employment quality and the characteristics of their job to explain their intention to quit their PhD thesis process. This study was based on 160 Belgian PhD candidates, viewed as traditional workers in the Belgian doctoral system, who were still in their thesis process. Data were collected in one Belgian university. Globally, results shown that only the fit perception between the needs for fairness/recognition from the supervisor and the current job situation was significantly associated with lower intention to quit. Thus, we encourage Universities to develop and boost fairness and recognition from thesis supervisors through notably specific training programmes including supportive and justice-based practices.Arc-understanding flexicurit

Discrepancy in Flexibility and Employment Security's Expectations: Impact on Well-Being at Work

ARC - Understanding Flexicurit