Towards precise completion of deformable shapes

According to Aristotle, “the whole is greater than the sum of its parts”. This statement was adopted to explain human perception by the Gestalt psychology school of thought in the twentieth century. Here, we claim that when observing a part of an object which was previously acquired as a whole, one could deal with both partial correspondence and shape completion in a holistic manner. More specifically, given the geometry of a full, articulated object in a given pose, as well as a partial scan of the same object in a different pose, we address the new problem of matching the part to the whole while simultaneously reconstructing the new pose from its partial observation. Our approach is data-driven and takes the form of a Siamese autoencoder without the requirement of a consistent vertex labeling at inference time; as such, it can be used on unorganized point clouds as well as on triangle meshes. We demonstrate the practical effectiveness of our model in the applications of single-view deformable shape completion and dense shape correspondence, both on synthetic and real-world geometric data, where we outperform prior work by a large margin

Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front-line with paediatric-inspired regimens: A retrospective multicentre Campus ALL study

Within the Campus ALL network we analyzed the incidence, characteristics, treatment and outcome of a central nervous system (CNS) relapse in 1035 consecutive adult acute lymphoblastic leukemia (ALL) patients treated frontline with pediatric-inspired protocols between 2009 and 2020. Seventy-one patients (6.8%) experienced a CNS recurrence, more frequently in T- (28/278; 10%) than in B-ALL (43/757; 5.7%) (p = 0.017). An early CNS relapse—< 12 months from diagnosis—was observed in 41 patients. In multivariate analysis, risk factors for early CNS relapse included T-cell phenotype (p = <0.001), hyperleucocytosis >100 × 109/L (p<0.001) and male gender (p = 0.015). Treatment was heterogeneous, including chemotherapy, radiotherapy, intrathecal therapy and novel agents. A complete remission (CR) was obtained in 39 patients (55%) with no differences among strategies. After CR, 26 patients underwent an allogenic transplant, with a significant overall survival benefit compared to non-transplanted patients (p = 0.012). After a median observation of 8 months from CNS relapse, 23 patients (32%) were alive. In multivariate analysis, the time to CNS relapse was the strongest predictor of a lower 2-year post-relapse survival (p<0.001). In conclusion, in adult ALL the outcome after a CNS relapse remains very poor. Effective CNS prophylaxis remains the best approach and allogenic transplant should be pursued when possible