6 research outputs found
Electrically mediated drug delivery for treatment of an adenocarcinoma transplanted into rat liver
BACKGROUND: In this study, electrochemotherapy (ECT), i.e. tumour treatment based on local augmentation of intracellular drug delivery from short, intense electric pulses, was evaluated in rats with an adenocarcinoma implanted into the liver. Tumour response and concentrations of macrophages and T-lymphocytes (CD4 and CD8) in and around the tumour were measured.MATERIALS AND METHODS: Rats were treated with permeabilizing electric pulses, bleomycin, or both, eight days after implantation of the tumour, while one group received sham treatment.RESULTS: Treatment with electric pulses and bleomycin resulted in a significantly reduced lesion volume and 92% cure rate (12 out of 13, p<0.0002 compared to the other treatment groups). The highest concentration of CD8 lymphocytes was found in tumours treated with electric pulses and bleomycin. Macrophages were found mainly in tumours treated with electric pulses, with or without bleomycin.CONCLUSION: Electrochemotherapy using millisecond exponential pulses and bleomycin is efficient in a rat liver tumour model and appears to stimulate the host's immune system
A Prospective Evaluation of Ultrasonic Dissector plus Harmonic Scalpel in Liver Resection
THE SIGNIFICANCE OF THE PORTAL INSULIN SECRETION IN INSULIN DEPENDENT PATIENTS WITH RESIDUAL β-CELL FUNCTION: A SAFEGUARD AGAINST HORMONAL AND METABOLIC DERANGEMENT
Δr in the Two-Higgs-Doublet Model at full one loop level—and beyond
After the recent discovery of a Higgs-like boson particle at the CERN
LHC-collider, it becomes more necessary than ever to prepare ourselves for
identifying its standard or non-standard nature. The Electroweak parameter
Delta r relating the values of the gauge boson masses [MW,MZ] and the Fermi
constant [G_F] is the traditional observable encoding high precision
information of the electroweak physics at the quantum level. In this work we
present a complete quantitative study of Delta r in the framework of the
general (unconstrained) Two-Higgs-Doublet Model (2HDM). First of all we report
on a systematic analysis of Delta r at the full one loop level in the general
2HDM, which to our knowledge was missing in the literature. Thereby we extract
a theoretical prediction for the mass of the W-boson in this model, taking MZ,
\alpha_{em} and G_F as experimental inputs. We find typical corrections leading
to mass shifts which help to improve the agreement
with the experimentally measured value, in a degree no less significant than in
the MSSM case. In the second part of our study we extend our calculation beyond
the mere one-loop order. We devise an effective Lagrangian approach that
captures the dominant higher order quantum effects on delta rho (viz. that part
of Delta r describing the breaking of the approximate SU(2) custodial symmetry)
in the limit of large Higgs boson self-interactions. This limit constitutes a
telltale property of the general 2HDM which is unmatched by e.g. the MSSM. Our
conclusion is that the Electroweak precision program to be conducted at the
LHC, and maybe at a future linear collider, can nicely complement the direct
searches. Should these distinctive loop effects be eventually found they would
signal a smoking gun hinting at non-standard Higgs physics.Comment: LaTeX, 12 figures, 4 tables. Extended discussion, references added.
Version accepted in Eur. Phys. J.