(p -Cymene)thioglycollatoruthenium(II) dimer; a complex with an ambi-basic S,O-donor ligand

The title compound was prepared from the (p-cymene)ruthenium chloride dimer and thioglycollic acid. The structure is a centrosymmetric dimer bridged by the soft-base S atoms, with the hard-base O atoms of the carboxylate group chelating to form a five-membered twisted-ring. The coordination of the ruthenium atoms is completed by a η6-p-cymene ligand, giving an 18-electron count. The Ru–S bonds are essentially equal at 2.396(1) Å

A survey of the literature pertaining to the role of the classroom teacher in helping secondary school pupils to understand and appreciate democracy as the American way of life

Thesis (Ed.M.)--Boston Universit

Mammy O\u27Mine

[Verse 1] I’ve read your letter, Mammy O’ Mine,Now I feel better, Mammy O’ Mine,Still I’m kinda homesick, too,No one can cure me, but you. [Chorus] Mammy O’ Mine,Below that Old Dixon Line,Oh, how I’m longing to kiss you,I miss you, all of the time,I kiss your picture each night,And read the letters you write,For they remind me, of days of long ago,Oh! Lordy, how I’d like to be with youWhen I’m alone,My thoughts go wandering home,Then I start thinking of you,And feeling so blue, I could cry,Now I know why,Daddy used to say, the good Lord bless’d us,When he gave us you, ‘cause you’re the bestes’,Angel divine,You wonderful Mammy O’ Mine. [Verse 2] When night is falling, Mammy O’ Mine,I hear you calling, Mammy O’ Mine,Like I did in childhood days,Days I’ll remember, always. [Chorus

Give A Little Credit To Your Dad : Why don\u27t you say a word for poor old father

https://digitalcommons.library.umaine.edu/mmb-vp/4778/thumbnail.jp

When I Come Back To You : We\u27ll Have A Yankee-Doodle Wedding

https://digitalcommons.library.umaine.edu/mmb-vp/2952/thumbnail.jp

Sialidase and sialyltransferase inhibitors : targeting pathogenicity and disease

Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and adding sialic acid to other glycans, play essential roles in viruses, bacteria, parasites, and humans. Sialic acid is often the terminal sugar on glycans protruding from the cell surface in humans and is an important component for recognition and cell function. Pathogens have evolved to exploit this and use sialic acid to either “cloak” themselves, ensuring they remain undetected, or as a mechanism to enable release of virus progeny. The development of inhibitors against SAs and STs therefore provides the opportunity to target a range of diseases. Inhibitors targeting viral, bacterial, or parasitic enzymes can directly target their pathogenicity in humans. Excellent examples of this can be found with the anti-influenza drugs Zanamivir (Relenza™, GlaxoSmithKline) and Oseltamivir (Tamiflu™, Roche and Gilead), which have been used in the clinic for over two decades. However, the development of resistance against these drugs means there is an ongoing need for novel potent and specific inhibitors. Humans possess 20 STs and four SAs that play essential roles in cellular function, but have also been implicated in cancer progression, as glycans on many cancer cells are found to be hyper-sialylated. Whilst much remains unknown about how STs function in relation to disease, it is clear that specific inhibitors of them can serve both as tools to gain a better understanding of their activity and form the basis for development of anti-cancer drugs. Here we review the recent developments in the design of SA and ST inhibitors against pathogens and humans.Publisher PDFPeer reviewe

An Analysis of the Effects of Lean Logistics on the Current Air Force Reparable Pipeline: A Simulation Study

This research investigates the effect of Lean Logistics proposals on the current Air Force repairables pipeline. Lean Logistics proposes reducing reparable asset levels at operating bases, reducing transportation time between bases and depots, and reducing depot repair times. Computer simulation is used as a tool to perform a 3X3X3 full factorial experiment to determine the effects of the Lean Logistics proposals on fully mission capable aircraft and transportation cost. Results indicate that lean Logistics outperforms the current repairables pipeline in term of fully mission capable aircraft. A cost benefit analysis is performed to determine the trade offs between transportation costs and asset outlays. Logistics management, Pipeline, Inventory, Transportation, Repair

A cross-sectional study of predatory publishing emails received by career development grant awardees

OBJECTIVE: To investigate the scope of academic spam emails (ASEs) among career development grant awardees and the factors associated with the amount of time spent addressing them. DESIGN: A cross-sectional survey of career development grant investigators via an anonymous online survey was conducted. In addition to demographic and professional information, we asked investigators to report the number of ASEs received each day, how they determined whether these emails were spam and time they spent per day addressing them. We used bivariate analysis to assess factors associated with the amount of time spent on ASEs. SETTING: An online survey sent via email on three separate occasions between November and December 2016. PARTICIPANTS: All National Institutes of Health career development awardees funded in the 2015 fiscal year. MAIN OUTCOME MEASURES: Factors associated with the amount of time spent addressing ASEs. RESULTS: A total of 3492 surveys were emailed, of which 206 (5.9%) were returned as undeliverable and 96 (2.7%) reported an out-of-office message; our overall response rate was 22.3% (n=733). All respondents reported receiving ASEs, with the majority (54.4%) receiving between 1 and 10 per day and spending between 1 and 10 min each day evaluating them. The amount of time respondents reported spending on ASEs was associated with the number of peer-reviewed journal articles authored (p<0.001), a history of publishing in open access format (p<0.01), the total number of ASEs received (p<0.001) and a feeling of having missed opportunities due to ignoring these emails (p=0.04). CONCLUSIONS: ASEs are a common distraction for career development grantees that may impact faculty productivity. There is an urgent need to mitigate this growing problem

Mate choice and gene expression signatures associated with nutritional adaptation in the medfly (Ceratitis capitata)

Evolutionary responses to nutrition are key to understanding host shifts and the resulting potential for reproductive isolation. Experimental evolution has previously been used to describe the responses of the medfly (Ceratitis capitata) to larval diets with different nutritional properties. Within 30 generations this led to divergence in larval development time, egg to adult survival and adaptation in adult body size. Here we used mRNA-seq to identify differences in gene expression patterns in these same populations, using males from the 60th generation of nutritional selection. We validated differential expression by using qRT-PCR and found that genes linked to metabolism, oxidative phosphorylation and proteolysis were significantly over-represented among the differentially expressed genes. The results provide the first genome-wide survey of the putative mechanisms underpinning evolved responses to nutritional adaptation. In addition, we tested the hypothesis that nutritional adaptation can alter mating patterns. We found evidence for assortative mating by diet at generation 60, but not 90. Hence, the pattern was variable across generations and there was no evidence overall for any isolating mating divergence between the lines. Overall, the results provide insight into the mechanisms underpinning dietary adaptation and extend our knowledge of which traits represent core responses to nutritional selection

Dust and Gas in the disc of HL Tauri: Surface density, dust settling, and dust-to-gas ratio

The recent ALMA observations of the disc surrounding HL Tau reveal a very complex dust spatial distribution. We present a radiative transfer model accounting for the observed gaps and bright rings as well as radial changes of the emissivity index. We find that the dust density is depleted by at least a factor 10 in the main gaps compared to the surrounding rings. Ring masses range from 10-100 M$_{\oplus}$ in dust, and, we find that each of the deepest gaps is consistent with the removal of up to 40 M$_{\oplus}$ of dust. If this material has accumulated into rocky bodies, these would be close to the point of runaway gas accretion. Our model indicates that the outermost ring is depleted in millimetre grains compared to the central rings. This suggests faster grain growth in the central regions and/or radial migration of the larger grains. The morphology of the gaps observed by ALMA - well separated and showing a high degree of contrast with the bright rings over all azimuths - indicates that the millimetre dust disc is geometrically thin (scale height $\approx$ 1 au at 100 au) and that a large amount of settling of large grains has already occurred. Assuming a standard dust settling model, we find that the observations are consistent with a turbulent viscosity coefficient of a few $10^{-4}$. We estimate the gas/dust ratio in this thin layer to be of the order of 5 if the initial ratio is 100. The HCO$^+$ and CO emission is consistent with gas in Keplerian motion around a 1.7 $M_\odot$ star at radii from $\leq 10 - 120\,$au.Comment: 12 pages, 8 figures, published in ApJ, same version as before but with slightly extended discussion on temperature and masses to account for literature published since initial submissio