Clinical comparisons of different fixed orthodontic retainers

Objective: The aim of this prospective clinical study was to compare the clinical outcomes of three different fixed lingual retainers, in terms of effects on periodontal health and success rate. Methods: Forty five patients aged 13 to 25 years were randomly assigned into three groups, using bonded upper and lower lingual retainers. The study groups were as follows: Group 1-BondA-Braid®, Group 2-everStick® ORTHO, Group 3-Super-Splint. The follow-up appointments were performed two weeks (Baseline=T0), one month (T1), three months (T2), and six months (T3) after the application of retainers. Plaque Index (PI), Gingival Index (GI), Probing Depth (PD), Bleeding in Probing (BOP) and Retainer Failure were assessed at each appointment. Results: The everStick Ortho group showed significantly lower PI values on the upper-lower lingual side after three (p=0.008) and six (p=0.001) months. The everStick Ortho group had significantly lower upper lingual (GI) levels after six months, and lower lingual side levels after one month. The Super-Splint group showed significantly lower PD values on the upper lingual side after six months. The everStick Ortho group presented significantly lower BOP levels after six months on the upper lingual side. No significant differences between the groups (p>0.05) in terms of retainer failure were found. Conclusions: The everStick Ortho group presented better results in terms of periodontal health. The failure rates of the retainers were similar

Parkinson's disease alters the composition of subgingival microbiome

Aim: The current study aimed to test the hypothesis that Parkinson's disease exacerbates periodontitis by altering its microbiome. Materials and Methods: Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, periodontitis patients (PD), and Parkinson's patients with periodontitis (PA+PD) were analyzed using the checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated with periodontal disease and health. Nextgeneration sequencing (NGS) of the 16S ribosomal RNA gene (V1-V3 regions) was performed to analyze the microbiome comprehensively. Results: Parkinson's patients had mild-to-moderate motor dysfunctions. Bleeding on probing was significantly increased in the PA+PD group compared to PD (p < 0.05). With checkerboard analysis, PA was associated with increased Treponema socranskii (p = 0.0062), Peptostreptococcaceae_[G-6] [Eubacterium]_nodatum (p = 0.0439), Parvimona micra (p < 0.0001), Prevotella melaninogenica (p = 0.0002), Lachnoanaerobaculum saburreum (p < 0.0001), and Streptococcus anginosus (p = 0.0020). Streptococcus intermedia (p = 0.0042), P. nodatum (p = 0.0022), P. micra (p = 0.0002), Treponema denticola (p = 0.0045), L.saburreum (p = 0.0267), P.melaninogenica (p = 0.0017), Campylobacter rectus (p = 0.0020), and T.socranskii (p = 0.0002) were higher; Aggregatibacter actinomycetemcomitans (p = 0.0072) was lower in deep pockets in the PA+PD compared to PD. Schaalia odontolytica (p = 0.0351) and A.actinomycetemcomitans (p = 0.002) were lower; C.rectus (p = 0.0002), P. micra (p = 0065), Streptococcus constellatus (p = 0.0151), T.denticola (p = 0.0141), P.melaninogenica (p = 0.0057), and T.socranskii (p = 0.0316) were higher in shallow pockets in the PA+PD. Diversity decreased in PD (p = 0.001) and PA+PD (p = 0.026) compared to control, with minimal differences in alpha and beta diversities among PD and PA+PD based on NGS results. Conclusion: These data demonstrated that Parkinson's disease modifies PD-associated subgingival microbiome.This research was supported by a grant from the NIH/NIA (R01AG062496 to A. Kantarci). ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute on Aging (NIA

Dental and periodontal health status of subjects with sickle cell disease

WOS: 000298209200008Background/purpose: Sickle cell disease (SCD) is a chronic, hereditary, autosomal recessive disorder. The pathophysiology of SCD is thought to result from polymerization of hemoglobin S in red blood cells under hypoxic conditions, which results in vaso-occlusion. The aim of this study was to determine the periodontal and dental health status of patients with SCD. Materials and methods: Fifty-five SCD patients and 41 healthy individuals were evaluated. Detailed medical and dental histories were taken, and a record made of dental status (missing teeth, restorations, impacted teeth, root canal treatment), periodontal status [plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP)], alveolar bone level (ABL), mandibular cortex index, and bone quality index. Results: Two hundred and six teeth were missing, and a total of 195 teeth had restorations. Between-group differences existed for the PI, GI, and BOP; these variables were higher in patients than in the healthy individuals (P < 0.0001). No between-group differences existed for PD. In patients, there was a positive correlation between PD and BOP (P < 0.0001; r = 0.657), PD and GI (P = 0.02; r = 0.299), PD and PI (P = 0.01; r = 0.343); BOP and GI (P < 0.0001; r = 0.503), BOP and PI (P < 0.0001; r = 0.496); and GI and PI (P = 0.003; r = 0.388). The ABL in patients was found to be similar to that of the general population with an unknown periodontal condition. Conclusion: No clinical periodontal disease or attachment loss was detected in patients. However the PI, GI, and BOP were significantly higher in patients with SCD, which may reflect an as yet undefined variable response to microbes. There were no significant differences, however, in pocket depth between the two groups. Therefore we are unable to confirm any significant relationship between SCD and periodontal diseases. Oral health is not a major concern for SCD patients. The reason for this finding may be the potentially severe complications of SCD, which mean that oral and dental problems are not major concerns for this particular group of patients

Peri-implant defektlerinin tedavisini takiben yapılan vida retansiyonlu bir hibrid protez: Olgu bildirisi

The etiology of marginal bone loss around osseointegrated implants is primarily based on the biomechanical and/or microbial factors. If stresses and strains around dental implants under functional loading conditions are expected to exceed the physiologic tolerance thresholds of the alveolar bone, the fixed hybrid prosthesis might be a more reliable treatment of choice instead of fixed metal ceramic restorations. The purpose of this article is to report the 1-year follow-up of the periodontal and prosthetic rehabilitation of a patient who has presented with symptoms of peri-implantitis due to incorrectly planned implant supported fixed metal ceramic bridge which was later replaced with screw-retained hybrid prosthesis following the treatment of peri-implant defects. Treatment helped to maintain patient's self-confidence and comfort, as well as favorable masticatory function. Rehabilitation with screw retained hybrid prosthesis is an ideal treatment of choice for maxillomandibular skeletal discrepancies.Osseointegre implantların etrafındaki kemik kaybının etyolojisi, primer olarak biyomekanik ve/veya mikrobiyal faktörlere dayanır. İnsan çene kemiklerinde oluşan gerilme ve gerilim kuvvetlerinin fizyolojik tolerans eşiğinin üstünde olduğu durumlarda; sabit metal seramik restorasyonların yerine, sabit hibrid protezler daha güvenilir bir tedavi seçeneği olabilir. Bu olgu bildirisinin amacı, yanlış olarak planlanmış implant destekli sabit bir metal seramik köprüye sahip olan ve mevcut implantlarında peri-implantitis bulunan bir hastanın; peri-implant defektlerinin tedavisi sonrasında periodontal ve protetik rehabilitasyonun 1 yıllık takibini sunmaktır. Yapılan tedavi, hastanın hem özgüveninin ve rahatının kazandırılmasını, hem de etkili bir çiğneme fonksiyonuna sahip olmasını sağlamıştır. Vida retansiyonlu hibrid protezler ile yapılan oral rehabilitasyon, maksillomandibular iskeletsel malokluzyonlar için ideal bir tedavi seçeneğidir

Akut myelomonosi̇ti̇k lösemi̇si̇ olan bi̇r hastanin peri̇odontal tedavi̇si̇

Acute myelomonocytic leukemia (AML) is a malignanthematopoetic clonal disease of bone marrow and impaired production of normal blood cells. The leukemic cell infiltration may be companied by anemia and thrombocytopenia. Oral manifestations of the disease are gingival ulcerations, mucositis, gingival bleeding and gingival enlargement. A 47-year-old-man with AML-M4 referred to periodontology clinic for treatment of gingival hyperplasia and bleeding. At the second appointment, diffuse gingival ulcerations were seen. Two teeth were extracted under antibiotic prophylaxis. Gingival specimens were sent to pathology. Histochemical/immunohistochemical analysis showed AML. His medical therapy continued with chemotherapy and allogeneic bone marrow transplantation. He died 9 months after initial diagnosis. This case report represents not only manifestations of AML such as gingival hyperplasia, ulcerations and bleeding, but also reflects the acute course of the disease in the oral cavity. Dental consultation is essential for diagnosis and improvement of medical conditions. Systemic diseases are not obstacles for dental/periodontal procedures under the proper circumstances.Akut miyelomonositik lösemi (AML), kemik iliğini kötü huylu, hemotopoetik klonal hastalığı olup, normal kan hücrelerinin üretimi hatalı olarak meydana gelmektedir. Lösemik hücre infiltrasyonuna, anemi ve trombositopenide eşlik edebilir. Hastalığın oral bulgularını, gingival ülserasyonlar, mukositis, dişeti kanaması ve dişetlerinde büyüme oluşturmaktadır. AML olarak teşhis edilen 47 yaşındaki, erkek hasta, dişetlerindeki büyüme ve dişeti kanamalarının tedavisi için, hematologu tarafından periodontoloji kliniğine yönlendirildi. Hastanın periodontoloji kliniğindeki ikinci randevusunda diffüz dişeti ülserasyonları mevcuttu. Aynı seansta, antibiyotik profilaksisi altında, hastanın iki dişi çekildi. Çekim bölgesinden toplanan dişeti dokusu, patolojik değerlendirme için patoloji bölümüne yönlendirildi. Dişeti dokusunda yapılan histokimyasal ve kimyasal/immunohistokimyasal analizler, AML tanısını doğruladı. Periodontal tedavisi biten hastaya kemoterapi uygulandı ve allojenik kemik iliği transplantasyonu yapıldı. Hasta ilk teşhisi takiben 9. ayda vefat etti. Bu vaka da, AML’nin oral bulguları olan dişeti büyümesi, dişeti ülserasyonları ve dişeti kanamaları açıkça izlendi. Bu bulguların seyri, hastalığın akut ilerleme safhaları ile paralellik göstermekteydi. Diş hekimi ile yapılan konsültasyonlar ve dental tedaviler, hastanın medikal durumunda düzelmeyle sonuçlanmıştır. Sistemik hastalıklar, uygun koşullar sağlandığında, dental ve periodontal girişimler için bir engel oluşturmamaktadır

Investigation of the effet of removable retainers on tooth mobility after orthodontic treatment

Giriş: Ortodontik tedavideki diş hareketleri esnasında gerek periodontal ligamentte (PDL) gerekse PDL’ye komşu kemikduvarında önemli fizyolojik değişiklikler meydana gelmektedir. Diş mobilitesi hem ortodontik tedavi boyunca hem de retansiyondöneminde periodonsiyumun biyomekanik özelliklerinin ve periodontal desteğin mevcudiyetinin değerlendirilmesinde önemli birgösterge olarak kullanılmaktadır. Bu çalışmanın amacı, ortodontik retansiyon amacı ile kullanılan Hawley ve Essix apareylerininmobilite üzerine etkisini zamana bağlı karşılaştırmalı olarak incelemek ve bu apareylerin klinik yararlanımlarını değerlendirmektir.Gereç ve Yöntem: Çalışmamıza sabit ortodontik tedavi sonrası retansiyon döneminde Hawley apareyi kullanan 29 ve Essixapareyi kullanan 16 olmak üzere toplam 45 (35 kadın,10 erkek) katılımcı dahil edilmiştir. Diş mobilite ölçümleri braketlersöküldükten hemen sonra (ilk ölçüm) ve sonrasında 1.hafta,1.,2.,3,6.,9, ve 12. aylarda olacak şekilde Periotest cihazınınüreticinin talimatlarına göre kullanılması ile yapılmıştır.Bulgular: Gruplar arası zamana bağlı Periotest değerleri karşılaştırıldığında Hawley grubunun ilk ölçüm, 2.ay, 3. ay ve 6. aymobilite düzeylerinin Essix grubuna göre istatistiksel olarak anlamlı düzeyde yüksek olduğu bulunmuştur (p0.05); ilk ölçüme göre 1. ay, 2. ay, 3. ay, 6. ay, 9. ay ve 12. ay ölçümlerinde görülendüşüşler istatistiksel olarak ileri düzeyde anlamlı bulunmuştur (p 0.05) whereas there was a statistically significant decrease in the measurements of the 1st, 2nd, 3rd, 6th, 9th and 12th months (p <0.01). The results were similar to Hawley group in Essix group (p <0.01). Periotest values decreased with time in both groups. Conclusion: In our results suggest that Hawley and Essix appliances, which are widely preferred in the retention period after orthodontic treatment, have similar clinical benefits on remodeling of orthodontic-induced mobility

FARKLI İKİ YAPIDA MEMBRAN KULLANILARAK GERÇEKLEŞTİRİLEN YÖNLENDİRİLMİŞ DOKU REJENERASYONU TEKNİĞİNİN 5 YILLIK KLİNİK SONUÇLARININ DEĞERLENDİRİLMESİ

Yaşları 20 ile 45 arasında değişen, 13 bireyeait, periodontal hastalık nedeni oluşmuş toplam 26 kemik içi defekt, yönlendirilmiş doku rejenerasyonu yöntemi ile tedavi edildi. Ayn› bireyin benzer iki kemik içi defektinden birine rezorbe olabilen glikoid ve laktid kopolimer esasl› Resolut membran, diğerine rezorbe olmayan e-PTFE esasl› Gore-tex membran rasgele seçilerek yerleştirilmiştir. Defekt bölgelerine ait plak indeksi, gingival indeks, sondlamada kanama indeksi, cep derinliği, ataçman seviyesi ve gingival marjin konumlar›n› içeren klinik ölçümler; operasyon öncesinde ve operasyonu takip eden 3., 6., 9., 12., 24., 36., 48. ve 60. aylarda kaydedildi. Resolut ve Gore-tex membran uygulanan gruplarda yap›lan grup içi değerlendirmelerde, her iki grupta da cep derinliğinde istatistiksel olarak anlaml› azalma, ataçman seviyesinde ise kazanç olduğu görüldü. Gruplar birbirleri ile karş›laşt›r›ld›klar›nda ise istatistiksel olarak fark olmad›ğ› görüldü. Çal›şman›n sonucunda, her iki membran›n rejeneratif tedavilerde benzer klinik iyileşme gösterdiğini ve 1. y›l sonunda elde edilen ataçman kazanc›n›n korunamad›ğ›n› görülmüştür. Uzun dönemde başar›l› sonuçlar elde etmek için idame dönemlerinin ve hasta motivasyonunun önemli olduğu düşünülmektedir

Salivary irisin level is higher and related with interleukin-6 in generalized periodontitis

Objectives: Irisin plays an important role in energy homeostasis, inflammation, glucose, and lipid metabolism, and it is shown to have relations with many inflammatory diseases. The aim of the study was to determine saliva and serum irisin and IL-6 levels in patients with stage III/grade B periodontitis compared with individuals with healthy periodontium. Materials and methods: Twenty patients with stage III grade B periodontitis (P) and 20 periodontally healthy subjects (control; C) were included in this study. Clinical periodontal measurements were recorded. Saliva and serum levels of irisin and interleukin-6 (IL-6) were analyzed by enzyme-linked immunosorbent assay. Results: Salivary irisin and IL-6 levels were significantly higher in the periodontitis group (p 0.05). Significant positive correlations were found between all periodontal parameters and salivary irisin and IL-6 (p < 0.05) and also between BMI and saliva and serum IL-6 (respectively; r = 0.530, r = 0.329, p < 0.05). There was a positive correlation between salivary irisin and IL-6 (r = 0.369, p < 0.05). Conclusions: Monitoring of salivary irisin and IL-6 might be potential biomarker for predicting the susceptibility to periodontitis. Clinical relevance: Scientific rationale for the study: Irisin is a novel adipomyokine that has played an important role in energy homeostasis, glucose and lipid metabolism, angiogenesis, immunity, and inflammation. Irisin is involved in the pathogenesis of diseases affecting many body systems. IL-6, another adipomyokine, is a major inflammatory mediator and homeostatic regulator of glucose and lipid metabolism and is associated with periodontitis. No studies investigated the relationship between advanced periodontal disease, irisin, and IL-6 together. Principal findings: The salivary irisin and IL-6 levels were significantly higher and positively correlated in patients with periodontitis relative to healthy controls. Furthermore, serum IL-6 levels were significantly increased in patients with periodontitis. Practical implications: The study shows that irisin and IL-6 can be candidate salivary biomarkers for periodontitis and predict to periodontal status

Adin implantlarının kısa dönem radyo frekans analiz ölçümleri

Background and Aim: The purpose of this study was to understand and monitor the transition from primary to secondary stability of implants having sand blast large grit acid etched surface, for the timing of the prosthodontic treatment via using the Radio Frequency Analysis. Subjects and Methods: Forty-two dental implants were placed in 19 patients and Implant Stability Quotient measurements were performed at baseline, 1st, 2nd, 3rd, 4th, 6th and 8th weeks. The lengths and diameters of the implants were also correlated with Implant Stability Quotient values. Results: The present data showed no correlation between lengths, diameters and Radio Frequency Analysis at any of the measurement times. In each group, implant stability at the baseline and 8th weeks showed significant higher Radio Frequency Analysis (RFA) values than the 2nd, 3rd and 4th weeks (p&lt;0.05). Statistically no difference was found between the baseline and 8th week measurements (p&gt;0.05).Conclusion: Measuring Implant Stability Quotient values can help the clinician understand the condition of the implant without disrupting the healing implant-bone interface, allowing to decide the loading time.Amaç: Bu çalışmanın amacı, kumlanmış-asitlenmiş yüzeye sahip implantların primer stabiliteden sekonder stabiliteye geçişini, Radyo Frekans Analiz yöntemi kullanarak anlamak ve gözlemlemektir. Bireyler ve Yöntem: Ondokuz hastada 42 implant yerleştirilmiş ve başlangıç, 1, 2, 3, 4, 6 ve 8. haftalarda İmplant Stabilite ölçümleri (Implant Stability Quotient-ISQ) yapılmıştır. Bulgular: Elde edilen bilgiler, implantların boyu ve çapı ile Radyo Frekans Analiz ölçümleri arasında hiçbir zaman diliminde ilişki göstermemektedir. Tüm gruplarda implant stabilitesi, başlangıç ve 8. haftada 2, 3 ve 4. haftalara göre anlamlı derecede yüksek İmplant Stabilite ölçüm değeri göstermiştir (p0.05).Sonuçlar: İmplant Stabilite değerlerini ölçmek, iyileşen implantkemik bağlantısına zarar vermeden, implantın iyileşme durumu hakkında fikir vererek yükleme zamanının kararında hekime yardımcı olabilir

Serum, saliva, and gingival tissue human beta-defensin levels in relation to retinoic acid use

BackgroundRetinoic acid is an active derivative of vitamin A and regulates the differentiation, proliferation, and antimicrobial peptide expression profiles of human cells. The aim of the present study was to analyze the effect of systemic retinoic acid use on serum, saliva, and gingival tissue levels of human beta-defensin (hBD)-1, hBD-2, and hBD-3. MethodsA total of 69 participants (34 systemic retinoic acid users and 35 healthy controls) were enrolled in this study. Plaque index, probing pocket depth, bleeding on probing (BOP), and clinical attachment loss were measured. Saliva and serum hBD-1, hBD-2, and hBD-3 levels were quantified by enzyme-linked immunosorbent assay. Gingival tissue hBD-1, hBD-2, and hBD-3 levels were determined by immunohistochemistry. A univariate general linear model was used in adjusted comparisons of hBD1, hBD-2, and hBD-3. P values of < 0.05 were considered statistically significant. ResultsReduced salivary levels of hBD-2 (P = 0.042), but not hBD-1 or hBD-3, were detected in systemic retinoic acid users compared to non-user controls. There was a significant difference in the adjusted (for BOP%) salivary hBD-2 concentrations between retinoic acid and control groups (P = 0.031). No difference was observed in serum or tissue levels of hBD-1, hBD-2, or hBD-3 between the two study groups. ConclusionSystemic retinoic acid use was associated with suppressed salivary hBD-2 level, which was independent of gingival inflammation